7Z23

Connexin43 hemi channel in nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0000139	cellular_component	Golgi membrane
A	0002376	biological_process	immune system process
A	0003161	biological_process	cardiac conduction system development
A	0005243	molecular_function	gap junction channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0005925	cellular_component	focal adhesion
A	0007154	biological_process	cell communication
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007283	biological_process	spermatogenesis
A	0007507	biological_process	heart development
A	0008013	molecular_function	beta-catenin binding
A	0008104	biological_process	intracellular protein localization
A	0010628	biological_process	positive regulation of gene expression
A	0010644	biological_process	cell communication by electrical coupling
A	0014047	biological_process	glutamate secretion
A	0014704	cellular_component	intercalated disc
A	0015075	molecular_function	monoatomic ion transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015631	molecular_function	tubulin binding
A	0016264	biological_process	gap junction assembly
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030054	cellular_component	cell junction
A	0030308	biological_process	negative regulation of cell growth
A	0030660	cellular_component	Golgi-associated vesicle membrane
A	0032277	biological_process	negative regulation of gonadotropin secretion
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034634	molecular_function	glutathione transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0035633	biological_process	maintenance of blood-brain barrier
A	0042908	biological_process	xenobiotic transport
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044291	cellular_component	cell-cell contact zone
A	0045087	biological_process	innate immune response
A	0045121	cellular_component	membrane raft
A	0045216	biological_process	cell-cell junction organization
A	0046849	biological_process	bone remodeling
A	0055077	molecular_function	gap junction hemi-channel activity
A	0060348	biological_process	bone development
A	0070160	cellular_component	tight junction
A	0070161	cellular_component	anchoring junction
A	0086014	biological_process	atrial cardiac muscle cell action potential
A	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
A	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	0140115	biological_process	export across plasma membrane
A	1901164	biological_process	negative regulation of trophoblast cell migration
A	1903522	biological_process	regulation of blood circulation
A	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
A	1904646	biological_process	cellular response to amyloid-beta
A	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
A	1905332	biological_process	positive regulation of morphogenesis of an epithelium
A	1905772	biological_process	positive regulation of mesodermal cell differentiation
A	2000648	biological_process	positive regulation of stem cell proliferation
B	0000132	biological_process	establishment of mitotic spindle orientation
B	0000139	cellular_component	Golgi membrane
B	0002376	biological_process	immune system process
B	0003161	biological_process	cardiac conduction system development
B	0005243	molecular_function	gap junction channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0005925	cellular_component	focal adhesion
B	0007154	biological_process	cell communication
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007283	biological_process	spermatogenesis
B	0007507	biological_process	heart development
B	0008013	molecular_function	beta-catenin binding
B	0008104	biological_process	intracellular protein localization
B	0010628	biological_process	positive regulation of gene expression
B	0010644	biological_process	cell communication by electrical coupling
B	0014047	biological_process	glutamate secretion
B	0014704	cellular_component	intercalated disc
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015631	molecular_function	tubulin binding
B	0016264	biological_process	gap junction assembly
B	0016324	cellular_component	apical plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0030054	cellular_component	cell junction
B	0030308	biological_process	negative regulation of cell growth
B	0030660	cellular_component	Golgi-associated vesicle membrane
B	0032277	biological_process	negative regulation of gonadotropin secretion
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034634	molecular_function	glutathione transmembrane transporter activity
B	0034775	biological_process	glutathione transmembrane transport
B	0035633	biological_process	maintenance of blood-brain barrier
B	0042908	biological_process	xenobiotic transport
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0044291	cellular_component	cell-cell contact zone
B	0045087	biological_process	innate immune response
B	0045121	cellular_component	membrane raft
B	0045216	biological_process	cell-cell junction organization
B	0046849	biological_process	bone remodeling
B	0055077	molecular_function	gap junction hemi-channel activity
B	0060348	biological_process	bone development
B	0070160	cellular_component	tight junction
B	0070161	cellular_component	anchoring junction
B	0086014	biological_process	atrial cardiac muscle cell action potential
B	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
B	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0140115	biological_process	export across plasma membrane
B	1901164	biological_process	negative regulation of trophoblast cell migration
B	1903522	biological_process	regulation of blood circulation
B	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
B	1904646	biological_process	cellular response to amyloid-beta
B	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
B	1905332	biological_process	positive regulation of morphogenesis of an epithelium
B	1905772	biological_process	positive regulation of mesodermal cell differentiation
B	2000648	biological_process	positive regulation of stem cell proliferation
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0000139	cellular_component	Golgi membrane
C	0002376	biological_process	immune system process
C	0003161	biological_process	cardiac conduction system development
C	0005243	molecular_function	gap junction channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0005925	cellular_component	focal adhesion
C	0007154	biological_process	cell communication
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007283	biological_process	spermatogenesis
C	0007507	biological_process	heart development
C	0008013	molecular_function	beta-catenin binding
C	0008104	biological_process	intracellular protein localization
C	0010628	biological_process	positive regulation of gene expression
C	0010644	biological_process	cell communication by electrical coupling
C	0014047	biological_process	glutamate secretion
C	0014704	cellular_component	intercalated disc
C	0015075	molecular_function	monoatomic ion transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015631	molecular_function	tubulin binding
C	0016264	biological_process	gap junction assembly
C	0016324	cellular_component	apical plasma membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0030054	cellular_component	cell junction
C	0030308	biological_process	negative regulation of cell growth
C	0030660	cellular_component	Golgi-associated vesicle membrane
C	0032277	biological_process	negative regulation of gonadotropin secretion
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034634	molecular_function	glutathione transmembrane transporter activity
C	0034775	biological_process	glutathione transmembrane transport
C	0035633	biological_process	maintenance of blood-brain barrier
C	0042908	biological_process	xenobiotic transport
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044291	cellular_component	cell-cell contact zone
C	0045087	biological_process	innate immune response
C	0045121	cellular_component	membrane raft
C	0045216	biological_process	cell-cell junction organization
C	0046849	biological_process	bone remodeling
C	0055077	molecular_function	gap junction hemi-channel activity
C	0060348	biological_process	bone development
C	0070160	cellular_component	tight junction
C	0070161	cellular_component	anchoring junction
C	0086014	biological_process	atrial cardiac muscle cell action potential
C	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
C	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0140115	biological_process	export across plasma membrane
C	1901164	biological_process	negative regulation of trophoblast cell migration
C	1903522	biological_process	regulation of blood circulation
C	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
C	1904646	biological_process	cellular response to amyloid-beta
C	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
C	1905332	biological_process	positive regulation of morphogenesis of an epithelium
C	1905772	biological_process	positive regulation of mesodermal cell differentiation
C	2000648	biological_process	positive regulation of stem cell proliferation
D	0000132	biological_process	establishment of mitotic spindle orientation
D	0000139	cellular_component	Golgi membrane
D	0002376	biological_process	immune system process
D	0003161	biological_process	cardiac conduction system development
D	0005243	molecular_function	gap junction channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0005925	cellular_component	focal adhesion
D	0007154	biological_process	cell communication
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007283	biological_process	spermatogenesis
D	0007507	biological_process	heart development
D	0008013	molecular_function	beta-catenin binding
D	0008104	biological_process	intracellular protein localization
D	0010628	biological_process	positive regulation of gene expression
D	0010644	biological_process	cell communication by electrical coupling
D	0014047	biological_process	glutamate secretion
D	0014704	cellular_component	intercalated disc
D	0015075	molecular_function	monoatomic ion transmembrane transporter activity
D	0015562	molecular_function	efflux transmembrane transporter activity
D	0015631	molecular_function	tubulin binding
D	0016264	biological_process	gap junction assembly
D	0016324	cellular_component	apical plasma membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0030054	cellular_component	cell junction
D	0030308	biological_process	negative regulation of cell growth
D	0030660	cellular_component	Golgi-associated vesicle membrane
D	0032277	biological_process	negative regulation of gonadotropin secretion
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034634	molecular_function	glutathione transmembrane transporter activity
D	0034775	biological_process	glutathione transmembrane transport
D	0035633	biological_process	maintenance of blood-brain barrier
D	0042908	biological_process	xenobiotic transport
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044291	cellular_component	cell-cell contact zone
D	0045087	biological_process	innate immune response
D	0045121	cellular_component	membrane raft
D	0045216	biological_process	cell-cell junction organization
D	0046849	biological_process	bone remodeling
D	0055077	molecular_function	gap junction hemi-channel activity
D	0060348	biological_process	bone development
D	0070160	cellular_component	tight junction
D	0070161	cellular_component	anchoring junction
D	0086014	biological_process	atrial cardiac muscle cell action potential
D	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
D	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0140115	biological_process	export across plasma membrane
D	1901164	biological_process	negative regulation of trophoblast cell migration
D	1903522	biological_process	regulation of blood circulation
D	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
D	1904646	biological_process	cellular response to amyloid-beta
D	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
D	1905332	biological_process	positive regulation of morphogenesis of an epithelium
D	1905772	biological_process	positive regulation of mesodermal cell differentiation
D	2000648	biological_process	positive regulation of stem cell proliferation
E	0000132	biological_process	establishment of mitotic spindle orientation
E	0000139	cellular_component	Golgi membrane
E	0002376	biological_process	immune system process
E	0003161	biological_process	cardiac conduction system development
E	0005243	molecular_function	gap junction channel activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0005925	cellular_component	focal adhesion
E	0007154	biological_process	cell communication
E	0007165	biological_process	signal transduction
E	0007267	biological_process	cell-cell signaling
E	0007283	biological_process	spermatogenesis
E	0007507	biological_process	heart development
E	0008013	molecular_function	beta-catenin binding
E	0008104	biological_process	intracellular protein localization
E	0010628	biological_process	positive regulation of gene expression
E	0010644	biological_process	cell communication by electrical coupling
E	0014047	biological_process	glutamate secretion
E	0014704	cellular_component	intercalated disc
E	0015075	molecular_function	monoatomic ion transmembrane transporter activity
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0015631	molecular_function	tubulin binding
E	0016264	biological_process	gap junction assembly
E	0016324	cellular_component	apical plasma membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0030054	cellular_component	cell junction
E	0030308	biological_process	negative regulation of cell growth
E	0030660	cellular_component	Golgi-associated vesicle membrane
E	0032277	biological_process	negative regulation of gonadotropin secretion
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034634	molecular_function	glutathione transmembrane transporter activity
E	0034775	biological_process	glutathione transmembrane transport
E	0035633	biological_process	maintenance of blood-brain barrier
E	0042908	biological_process	xenobiotic transport
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0044291	cellular_component	cell-cell contact zone
E	0045087	biological_process	innate immune response
E	0045121	cellular_component	membrane raft
E	0045216	biological_process	cell-cell junction organization
E	0046849	biological_process	bone remodeling
E	0055077	molecular_function	gap junction hemi-channel activity
E	0060348	biological_process	bone development
E	0070160	cellular_component	tight junction
E	0070161	cellular_component	anchoring junction
E	0086014	biological_process	atrial cardiac muscle cell action potential
E	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
E	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	0140115	biological_process	export across plasma membrane
E	1901164	biological_process	negative regulation of trophoblast cell migration
E	1903522	biological_process	regulation of blood circulation
E	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
E	1904646	biological_process	cellular response to amyloid-beta
E	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
E	1905332	biological_process	positive regulation of morphogenesis of an epithelium
E	1905772	biological_process	positive regulation of mesodermal cell differentiation
E	2000648	biological_process	positive regulation of stem cell proliferation
F	0000132	biological_process	establishment of mitotic spindle orientation
F	0000139	cellular_component	Golgi membrane
F	0002376	biological_process	immune system process
F	0003161	biological_process	cardiac conduction system development
F	0005243	molecular_function	gap junction channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0005925	cellular_component	focal adhesion
F	0007154	biological_process	cell communication
F	0007165	biological_process	signal transduction
F	0007267	biological_process	cell-cell signaling
F	0007283	biological_process	spermatogenesis
F	0007507	biological_process	heart development
F	0008013	molecular_function	beta-catenin binding
F	0008104	biological_process	intracellular protein localization
F	0010628	biological_process	positive regulation of gene expression
F	0010644	biological_process	cell communication by electrical coupling
F	0014047	biological_process	glutamate secretion
F	0014704	cellular_component	intercalated disc
F	0015075	molecular_function	monoatomic ion transmembrane transporter activity
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0015631	molecular_function	tubulin binding
F	0016264	biological_process	gap junction assembly
F	0016324	cellular_component	apical plasma membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0030054	cellular_component	cell junction
F	0030308	biological_process	negative regulation of cell growth
F	0030660	cellular_component	Golgi-associated vesicle membrane
F	0032277	biological_process	negative regulation of gonadotropin secretion
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034634	molecular_function	glutathione transmembrane transporter activity
F	0034775	biological_process	glutathione transmembrane transport
F	0035633	biological_process	maintenance of blood-brain barrier
F	0042908	biological_process	xenobiotic transport
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0044291	cellular_component	cell-cell contact zone
F	0045087	biological_process	innate immune response
F	0045121	cellular_component	membrane raft
F	0045216	biological_process	cell-cell junction organization
F	0046849	biological_process	bone remodeling
F	0055077	molecular_function	gap junction hemi-channel activity
F	0060348	biological_process	bone development
F	0070160	cellular_component	tight junction
F	0070161	cellular_component	anchoring junction
F	0086014	biological_process	atrial cardiac muscle cell action potential
F	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
F	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	0140115	biological_process	export across plasma membrane
F	1901164	biological_process	negative regulation of trophoblast cell migration
F	1903522	biological_process	regulation of blood circulation
F	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
F	1904646	biological_process	cellular response to amyloid-beta
F	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
F	1905332	biological_process	positive regulation of morphogenesis of an epithelium
F	1905772	biological_process	positive regulation of mesodermal cell differentiation
F	2000648	biological_process	positive regulation of stem cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD

Chain	Residue	Details
E	CYS54-ASP67

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Ckrd.PCphqVDCFLSRP

Chain	Residue	Details
E	CYS187-PRO203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	126
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	366
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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