7Z22

Connexin43 gap junction channel structure in nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0000139	cellular_component	Golgi membrane
A	0003161	biological_process	cardiac conduction system development
A	0005243	molecular_function	gap junction channel activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0005925	cellular_component	focal adhesion
A	0007154	biological_process	cell communication
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007283	biological_process	spermatogenesis
A	0007507	biological_process	heart development
A	0008013	molecular_function	beta-catenin binding
A	0008104	biological_process	protein localization
A	0010628	biological_process	positive regulation of gene expression
A	0010644	biological_process	cell communication by electrical coupling
A	0014047	biological_process	glutamate secretion
A	0014704	cellular_component	intercalated disc
A	0015075	molecular_function	monoatomic ion transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015631	molecular_function	tubulin binding
A	0016020	cellular_component	membrane
A	0016264	biological_process	gap junction assembly
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030054	cellular_component	cell junction
A	0030308	biological_process	negative regulation of cell growth
A	0030660	cellular_component	Golgi-associated vesicle membrane
A	0032277	biological_process	negative regulation of gonadotropin secretion
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034634	molecular_function	glutathione transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0035633	biological_process	maintenance of blood-brain barrier
A	0042908	biological_process	xenobiotic transport
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044291	cellular_component	cell-cell contact zone
A	0045121	cellular_component	membrane raft
A	0045216	biological_process	cell-cell junction organization
A	0046849	biological_process	bone remodeling
A	0055077	molecular_function	gap junction hemi-channel activity
A	0060348	biological_process	bone development
A	0070160	cellular_component	tight junction
A	0070161	cellular_component	anchoring junction
A	0086014	biological_process	atrial cardiac muscle cell action potential
A	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
A	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	0140115	biological_process	export across plasma membrane
A	1901164	biological_process	negative regulation of trophoblast cell migration
A	1903522	biological_process	regulation of blood circulation
A	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
A	1904646	biological_process	cellular response to amyloid-beta
A	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
A	1905332	biological_process	positive regulation of morphogenesis of an epithelium
A	1905772	biological_process	positive regulation of mesodermal cell differentiation
A	2000648	biological_process	positive regulation of stem cell proliferation
B	0000132	biological_process	establishment of mitotic spindle orientation
B	0000139	cellular_component	Golgi membrane
B	0003161	biological_process	cardiac conduction system development
B	0005243	molecular_function	gap junction channel activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0005925	cellular_component	focal adhesion
B	0007154	biological_process	cell communication
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007283	biological_process	spermatogenesis
B	0007507	biological_process	heart development
B	0008013	molecular_function	beta-catenin binding
B	0008104	biological_process	protein localization
B	0010628	biological_process	positive regulation of gene expression
B	0010644	biological_process	cell communication by electrical coupling
B	0014047	biological_process	glutamate secretion
B	0014704	cellular_component	intercalated disc
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015631	molecular_function	tubulin binding
B	0016020	cellular_component	membrane
B	0016264	biological_process	gap junction assembly
B	0016324	cellular_component	apical plasma membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0030054	cellular_component	cell junction
B	0030308	biological_process	negative regulation of cell growth
B	0030660	cellular_component	Golgi-associated vesicle membrane
B	0032277	biological_process	negative regulation of gonadotropin secretion
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034634	molecular_function	glutathione transmembrane transporter activity
B	0034775	biological_process	glutathione transmembrane transport
B	0035633	biological_process	maintenance of blood-brain barrier
B	0042908	biological_process	xenobiotic transport
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0044291	cellular_component	cell-cell contact zone
B	0045121	cellular_component	membrane raft
B	0045216	biological_process	cell-cell junction organization
B	0046849	biological_process	bone remodeling
B	0055077	molecular_function	gap junction hemi-channel activity
B	0060348	biological_process	bone development
B	0070160	cellular_component	tight junction
B	0070161	cellular_component	anchoring junction
B	0086014	biological_process	atrial cardiac muscle cell action potential
B	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
B	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0140115	biological_process	export across plasma membrane
B	1901164	biological_process	negative regulation of trophoblast cell migration
B	1903522	biological_process	regulation of blood circulation
B	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
B	1904646	biological_process	cellular response to amyloid-beta
B	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
B	1905332	biological_process	positive regulation of morphogenesis of an epithelium
B	1905772	biological_process	positive regulation of mesodermal cell differentiation
B	2000648	biological_process	positive regulation of stem cell proliferation
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0000139	cellular_component	Golgi membrane
C	0003161	biological_process	cardiac conduction system development
C	0005243	molecular_function	gap junction channel activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0005925	cellular_component	focal adhesion
C	0007154	biological_process	cell communication
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007283	biological_process	spermatogenesis
C	0007507	biological_process	heart development
C	0008013	molecular_function	beta-catenin binding
C	0008104	biological_process	protein localization
C	0010628	biological_process	positive regulation of gene expression
C	0010644	biological_process	cell communication by electrical coupling
C	0014047	biological_process	glutamate secretion
C	0014704	cellular_component	intercalated disc
C	0015075	molecular_function	monoatomic ion transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015631	molecular_function	tubulin binding
C	0016020	cellular_component	membrane
C	0016264	biological_process	gap junction assembly
C	0016324	cellular_component	apical plasma membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0030054	cellular_component	cell junction
C	0030308	biological_process	negative regulation of cell growth
C	0030660	cellular_component	Golgi-associated vesicle membrane
C	0032277	biological_process	negative regulation of gonadotropin secretion
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034634	molecular_function	glutathione transmembrane transporter activity
C	0034775	biological_process	glutathione transmembrane transport
C	0035633	biological_process	maintenance of blood-brain barrier
C	0042908	biological_process	xenobiotic transport
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044291	cellular_component	cell-cell contact zone
C	0045121	cellular_component	membrane raft
C	0045216	biological_process	cell-cell junction organization
C	0046849	biological_process	bone remodeling
C	0055077	molecular_function	gap junction hemi-channel activity
C	0060348	biological_process	bone development
C	0070160	cellular_component	tight junction
C	0070161	cellular_component	anchoring junction
C	0086014	biological_process	atrial cardiac muscle cell action potential
C	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
C	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0140115	biological_process	export across plasma membrane
C	1901164	biological_process	negative regulation of trophoblast cell migration
C	1903522	biological_process	regulation of blood circulation
C	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
C	1904646	biological_process	cellular response to amyloid-beta
C	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
C	1905332	biological_process	positive regulation of morphogenesis of an epithelium
C	1905772	biological_process	positive regulation of mesodermal cell differentiation
C	2000648	biological_process	positive regulation of stem cell proliferation
D	0000132	biological_process	establishment of mitotic spindle orientation
D	0000139	cellular_component	Golgi membrane
D	0003161	biological_process	cardiac conduction system development
D	0005243	molecular_function	gap junction channel activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0005925	cellular_component	focal adhesion
D	0007154	biological_process	cell communication
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007283	biological_process	spermatogenesis
D	0007507	biological_process	heart development
D	0008013	molecular_function	beta-catenin binding
D	0008104	biological_process	protein localization
D	0010628	biological_process	positive regulation of gene expression
D	0010644	biological_process	cell communication by electrical coupling
D	0014047	biological_process	glutamate secretion
D	0014704	cellular_component	intercalated disc
D	0015075	molecular_function	monoatomic ion transmembrane transporter activity
D	0015562	molecular_function	efflux transmembrane transporter activity
D	0015631	molecular_function	tubulin binding
D	0016020	cellular_component	membrane
D	0016264	biological_process	gap junction assembly
D	0016324	cellular_component	apical plasma membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0030054	cellular_component	cell junction
D	0030308	biological_process	negative regulation of cell growth
D	0030660	cellular_component	Golgi-associated vesicle membrane
D	0032277	biological_process	negative regulation of gonadotropin secretion
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034634	molecular_function	glutathione transmembrane transporter activity
D	0034775	biological_process	glutathione transmembrane transport
D	0035633	biological_process	maintenance of blood-brain barrier
D	0042908	biological_process	xenobiotic transport
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044291	cellular_component	cell-cell contact zone
D	0045121	cellular_component	membrane raft
D	0045216	biological_process	cell-cell junction organization
D	0046849	biological_process	bone remodeling
D	0055077	molecular_function	gap junction hemi-channel activity
D	0060348	biological_process	bone development
D	0070160	cellular_component	tight junction
D	0070161	cellular_component	anchoring junction
D	0086014	biological_process	atrial cardiac muscle cell action potential
D	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
D	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
D	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0140115	biological_process	export across plasma membrane
D	1901164	biological_process	negative regulation of trophoblast cell migration
D	1903522	biological_process	regulation of blood circulation
D	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
D	1904646	biological_process	cellular response to amyloid-beta
D	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
D	1905332	biological_process	positive regulation of morphogenesis of an epithelium
D	1905772	biological_process	positive regulation of mesodermal cell differentiation
D	2000648	biological_process	positive regulation of stem cell proliferation
E	0000132	biological_process	establishment of mitotic spindle orientation
E	0000139	cellular_component	Golgi membrane
E	0003161	biological_process	cardiac conduction system development
E	0005243	molecular_function	gap junction channel activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0005925	cellular_component	focal adhesion
E	0007154	biological_process	cell communication
E	0007165	biological_process	signal transduction
E	0007267	biological_process	cell-cell signaling
E	0007283	biological_process	spermatogenesis
E	0007507	biological_process	heart development
E	0008013	molecular_function	beta-catenin binding
E	0008104	biological_process	protein localization
E	0010628	biological_process	positive regulation of gene expression
E	0010644	biological_process	cell communication by electrical coupling
E	0014047	biological_process	glutamate secretion
E	0014704	cellular_component	intercalated disc
E	0015075	molecular_function	monoatomic ion transmembrane transporter activity
E	0015562	molecular_function	efflux transmembrane transporter activity
E	0015631	molecular_function	tubulin binding
E	0016020	cellular_component	membrane
E	0016264	biological_process	gap junction assembly
E	0016324	cellular_component	apical plasma membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0030054	cellular_component	cell junction
E	0030308	biological_process	negative regulation of cell growth
E	0030660	cellular_component	Golgi-associated vesicle membrane
E	0032277	biological_process	negative regulation of gonadotropin secretion
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034634	molecular_function	glutathione transmembrane transporter activity
E	0034775	biological_process	glutathione transmembrane transport
E	0035633	biological_process	maintenance of blood-brain barrier
E	0042908	biological_process	xenobiotic transport
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0044291	cellular_component	cell-cell contact zone
E	0045121	cellular_component	membrane raft
E	0045216	biological_process	cell-cell junction organization
E	0046849	biological_process	bone remodeling
E	0055077	molecular_function	gap junction hemi-channel activity
E	0060348	biological_process	bone development
E	0070160	cellular_component	tight junction
E	0070161	cellular_component	anchoring junction
E	0086014	biological_process	atrial cardiac muscle cell action potential
E	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
E	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
E	0120162	biological_process	positive regulation of cold-induced thermogenesis
E	0140115	biological_process	export across plasma membrane
E	1901164	biological_process	negative regulation of trophoblast cell migration
E	1903522	biological_process	regulation of blood circulation
E	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
E	1904646	biological_process	cellular response to amyloid-beta
E	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
E	1905332	biological_process	positive regulation of morphogenesis of an epithelium
E	1905772	biological_process	positive regulation of mesodermal cell differentiation
E	2000648	biological_process	positive regulation of stem cell proliferation
F	0000132	biological_process	establishment of mitotic spindle orientation
F	0000139	cellular_component	Golgi membrane
F	0003161	biological_process	cardiac conduction system development
F	0005243	molecular_function	gap junction channel activity
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0005925	cellular_component	focal adhesion
F	0007154	biological_process	cell communication
F	0007165	biological_process	signal transduction
F	0007267	biological_process	cell-cell signaling
F	0007283	biological_process	spermatogenesis
F	0007507	biological_process	heart development
F	0008013	molecular_function	beta-catenin binding
F	0008104	biological_process	protein localization
F	0010628	biological_process	positive regulation of gene expression
F	0010644	biological_process	cell communication by electrical coupling
F	0014047	biological_process	glutamate secretion
F	0014704	cellular_component	intercalated disc
F	0015075	molecular_function	monoatomic ion transmembrane transporter activity
F	0015562	molecular_function	efflux transmembrane transporter activity
F	0015631	molecular_function	tubulin binding
F	0016020	cellular_component	membrane
F	0016264	biological_process	gap junction assembly
F	0016324	cellular_component	apical plasma membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0030054	cellular_component	cell junction
F	0030308	biological_process	negative regulation of cell growth
F	0030660	cellular_component	Golgi-associated vesicle membrane
F	0032277	biological_process	negative regulation of gonadotropin secretion
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034634	molecular_function	glutathione transmembrane transporter activity
F	0034775	biological_process	glutathione transmembrane transport
F	0035633	biological_process	maintenance of blood-brain barrier
F	0042908	biological_process	xenobiotic transport
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0044291	cellular_component	cell-cell contact zone
F	0045121	cellular_component	membrane raft
F	0045216	biological_process	cell-cell junction organization
F	0046849	biological_process	bone remodeling
F	0055077	molecular_function	gap junction hemi-channel activity
F	0060348	biological_process	bone development
F	0070160	cellular_component	tight junction
F	0070161	cellular_component	anchoring junction
F	0086014	biological_process	atrial cardiac muscle cell action potential
F	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
F	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
F	0120162	biological_process	positive regulation of cold-induced thermogenesis
F	0140115	biological_process	export across plasma membrane
F	1901164	biological_process	negative regulation of trophoblast cell migration
F	1903522	biological_process	regulation of blood circulation
F	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
F	1904646	biological_process	cellular response to amyloid-beta
F	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
F	1905332	biological_process	positive regulation of morphogenesis of an epithelium
F	1905772	biological_process	positive regulation of mesodermal cell differentiation
F	2000648	biological_process	positive regulation of stem cell proliferation
G	0000132	biological_process	establishment of mitotic spindle orientation
G	0000139	cellular_component	Golgi membrane
G	0003161	biological_process	cardiac conduction system development
G	0005243	molecular_function	gap junction channel activity
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0005921	cellular_component	gap junction
G	0005922	cellular_component	connexin complex
G	0005925	cellular_component	focal adhesion
G	0007154	biological_process	cell communication
G	0007165	biological_process	signal transduction
G	0007267	biological_process	cell-cell signaling
G	0007283	biological_process	spermatogenesis
G	0007507	biological_process	heart development
G	0008013	molecular_function	beta-catenin binding
G	0008104	biological_process	protein localization
G	0010628	biological_process	positive regulation of gene expression
G	0010644	biological_process	cell communication by electrical coupling
G	0014047	biological_process	glutamate secretion
G	0014704	cellular_component	intercalated disc
G	0015075	molecular_function	monoatomic ion transmembrane transporter activity
G	0015562	molecular_function	efflux transmembrane transporter activity
G	0015631	molecular_function	tubulin binding
G	0016020	cellular_component	membrane
G	0016264	biological_process	gap junction assembly
G	0016324	cellular_component	apical plasma membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0030054	cellular_component	cell junction
G	0030308	biological_process	negative regulation of cell growth
G	0030660	cellular_component	Golgi-associated vesicle membrane
G	0032277	biological_process	negative regulation of gonadotropin secretion
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034634	molecular_function	glutathione transmembrane transporter activity
G	0034775	biological_process	glutathione transmembrane transport
G	0035633	biological_process	maintenance of blood-brain barrier
G	0042908	biological_process	xenobiotic transport
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0044291	cellular_component	cell-cell contact zone
G	0045121	cellular_component	membrane raft
G	0045216	biological_process	cell-cell junction organization
G	0046849	biological_process	bone remodeling
G	0055077	molecular_function	gap junction hemi-channel activity
G	0060348	biological_process	bone development
G	0070160	cellular_component	tight junction
G	0070161	cellular_component	anchoring junction
G	0086014	biological_process	atrial cardiac muscle cell action potential
G	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
G	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
G	0120162	biological_process	positive regulation of cold-induced thermogenesis
G	0140115	biological_process	export across plasma membrane
G	1901164	biological_process	negative regulation of trophoblast cell migration
G	1903522	biological_process	regulation of blood circulation
G	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
G	1904646	biological_process	cellular response to amyloid-beta
G	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
G	1905332	biological_process	positive regulation of morphogenesis of an epithelium
G	1905772	biological_process	positive regulation of mesodermal cell differentiation
G	2000648	biological_process	positive regulation of stem cell proliferation
H	0000132	biological_process	establishment of mitotic spindle orientation
H	0000139	cellular_component	Golgi membrane
H	0003161	biological_process	cardiac conduction system development
H	0005243	molecular_function	gap junction channel activity
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005794	cellular_component	Golgi apparatus
H	0005886	cellular_component	plasma membrane
H	0005921	cellular_component	gap junction
H	0005922	cellular_component	connexin complex
H	0005925	cellular_component	focal adhesion
H	0007154	biological_process	cell communication
H	0007165	biological_process	signal transduction
H	0007267	biological_process	cell-cell signaling
H	0007283	biological_process	spermatogenesis
H	0007507	biological_process	heart development
H	0008013	molecular_function	beta-catenin binding
H	0008104	biological_process	protein localization
H	0010628	biological_process	positive regulation of gene expression
H	0010644	biological_process	cell communication by electrical coupling
H	0014047	biological_process	glutamate secretion
H	0014704	cellular_component	intercalated disc
H	0015075	molecular_function	monoatomic ion transmembrane transporter activity
H	0015562	molecular_function	efflux transmembrane transporter activity
H	0015631	molecular_function	tubulin binding
H	0016020	cellular_component	membrane
H	0016264	biological_process	gap junction assembly
H	0016324	cellular_component	apical plasma membrane
H	0022857	molecular_function	transmembrane transporter activity
H	0030054	cellular_component	cell junction
H	0030308	biological_process	negative regulation of cell growth
H	0030660	cellular_component	Golgi-associated vesicle membrane
H	0032277	biological_process	negative regulation of gonadotropin secretion
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0034634	molecular_function	glutathione transmembrane transporter activity
H	0034775	biological_process	glutathione transmembrane transport
H	0035633	biological_process	maintenance of blood-brain barrier
H	0042908	biological_process	xenobiotic transport
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0044291	cellular_component	cell-cell contact zone
H	0045121	cellular_component	membrane raft
H	0045216	biological_process	cell-cell junction organization
H	0046849	biological_process	bone remodeling
H	0055077	molecular_function	gap junction hemi-channel activity
H	0060348	biological_process	bone development
H	0070160	cellular_component	tight junction
H	0070161	cellular_component	anchoring junction
H	0086014	biological_process	atrial cardiac muscle cell action potential
H	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
H	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
H	0120162	biological_process	positive regulation of cold-induced thermogenesis
H	0140115	biological_process	export across plasma membrane
H	1901164	biological_process	negative regulation of trophoblast cell migration
H	1903522	biological_process	regulation of blood circulation
H	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
H	1904646	biological_process	cellular response to amyloid-beta
H	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
H	1905332	biological_process	positive regulation of morphogenesis of an epithelium
H	1905772	biological_process	positive regulation of mesodermal cell differentiation
H	2000648	biological_process	positive regulation of stem cell proliferation
I	0000132	biological_process	establishment of mitotic spindle orientation
I	0000139	cellular_component	Golgi membrane
I	0003161	biological_process	cardiac conduction system development
I	0005243	molecular_function	gap junction channel activity
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005794	cellular_component	Golgi apparatus
I	0005886	cellular_component	plasma membrane
I	0005921	cellular_component	gap junction
I	0005922	cellular_component	connexin complex
I	0005925	cellular_component	focal adhesion
I	0007154	biological_process	cell communication
I	0007165	biological_process	signal transduction
I	0007267	biological_process	cell-cell signaling
I	0007283	biological_process	spermatogenesis
I	0007507	biological_process	heart development
I	0008013	molecular_function	beta-catenin binding
I	0008104	biological_process	protein localization
I	0010628	biological_process	positive regulation of gene expression
I	0010644	biological_process	cell communication by electrical coupling
I	0014047	biological_process	glutamate secretion
I	0014704	cellular_component	intercalated disc
I	0015075	molecular_function	monoatomic ion transmembrane transporter activity
I	0015562	molecular_function	efflux transmembrane transporter activity
I	0015631	molecular_function	tubulin binding
I	0016020	cellular_component	membrane
I	0016264	biological_process	gap junction assembly
I	0016324	cellular_component	apical plasma membrane
I	0022857	molecular_function	transmembrane transporter activity
I	0030054	cellular_component	cell junction
I	0030308	biological_process	negative regulation of cell growth
I	0030660	cellular_component	Golgi-associated vesicle membrane
I	0032277	biological_process	negative regulation of gonadotropin secretion
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0034634	molecular_function	glutathione transmembrane transporter activity
I	0034775	biological_process	glutathione transmembrane transport
I	0035633	biological_process	maintenance of blood-brain barrier
I	0042908	biological_process	xenobiotic transport
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0044291	cellular_component	cell-cell contact zone
I	0045121	cellular_component	membrane raft
I	0045216	biological_process	cell-cell junction organization
I	0046849	biological_process	bone remodeling
I	0055077	molecular_function	gap junction hemi-channel activity
I	0060348	biological_process	bone development
I	0070160	cellular_component	tight junction
I	0070161	cellular_component	anchoring junction
I	0086014	biological_process	atrial cardiac muscle cell action potential
I	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
I	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
I	0120162	biological_process	positive regulation of cold-induced thermogenesis
I	0140115	biological_process	export across plasma membrane
I	1901164	biological_process	negative regulation of trophoblast cell migration
I	1903522	biological_process	regulation of blood circulation
I	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
I	1904646	biological_process	cellular response to amyloid-beta
I	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
I	1905332	biological_process	positive regulation of morphogenesis of an epithelium
I	1905772	biological_process	positive regulation of mesodermal cell differentiation
I	2000648	biological_process	positive regulation of stem cell proliferation
J	0000132	biological_process	establishment of mitotic spindle orientation
J	0000139	cellular_component	Golgi membrane
J	0003161	biological_process	cardiac conduction system development
J	0005243	molecular_function	gap junction channel activity
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0005921	cellular_component	gap junction
J	0005922	cellular_component	connexin complex
J	0005925	cellular_component	focal adhesion
J	0007154	biological_process	cell communication
J	0007165	biological_process	signal transduction
J	0007267	biological_process	cell-cell signaling
J	0007283	biological_process	spermatogenesis
J	0007507	biological_process	heart development
J	0008013	molecular_function	beta-catenin binding
J	0008104	biological_process	protein localization
J	0010628	biological_process	positive regulation of gene expression
J	0010644	biological_process	cell communication by electrical coupling
J	0014047	biological_process	glutamate secretion
J	0014704	cellular_component	intercalated disc
J	0015075	molecular_function	monoatomic ion transmembrane transporter activity
J	0015562	molecular_function	efflux transmembrane transporter activity
J	0015631	molecular_function	tubulin binding
J	0016020	cellular_component	membrane
J	0016264	biological_process	gap junction assembly
J	0016324	cellular_component	apical plasma membrane
J	0022857	molecular_function	transmembrane transporter activity
J	0030054	cellular_component	cell junction
J	0030308	biological_process	negative regulation of cell growth
J	0030660	cellular_component	Golgi-associated vesicle membrane
J	0032277	biological_process	negative regulation of gonadotropin secretion
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0034634	molecular_function	glutathione transmembrane transporter activity
J	0034775	biological_process	glutathione transmembrane transport
J	0035633	biological_process	maintenance of blood-brain barrier
J	0042908	biological_process	xenobiotic transport
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0044291	cellular_component	cell-cell contact zone
J	0045121	cellular_component	membrane raft
J	0045216	biological_process	cell-cell junction organization
J	0046849	biological_process	bone remodeling
J	0055077	molecular_function	gap junction hemi-channel activity
J	0060348	biological_process	bone development
J	0070160	cellular_component	tight junction
J	0070161	cellular_component	anchoring junction
J	0086014	biological_process	atrial cardiac muscle cell action potential
J	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
J	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
J	0120162	biological_process	positive regulation of cold-induced thermogenesis
J	0140115	biological_process	export across plasma membrane
J	1901164	biological_process	negative regulation of trophoblast cell migration
J	1903522	biological_process	regulation of blood circulation
J	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
J	1904646	biological_process	cellular response to amyloid-beta
J	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
J	1905332	biological_process	positive regulation of morphogenesis of an epithelium
J	1905772	biological_process	positive regulation of mesodermal cell differentiation
J	2000648	biological_process	positive regulation of stem cell proliferation
K	0000132	biological_process	establishment of mitotic spindle orientation
K	0000139	cellular_component	Golgi membrane
K	0003161	biological_process	cardiac conduction system development
K	0005243	molecular_function	gap junction channel activity
K	0005515	molecular_function	protein binding
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005794	cellular_component	Golgi apparatus
K	0005886	cellular_component	plasma membrane
K	0005921	cellular_component	gap junction
K	0005922	cellular_component	connexin complex
K	0005925	cellular_component	focal adhesion
K	0007154	biological_process	cell communication
K	0007165	biological_process	signal transduction
K	0007267	biological_process	cell-cell signaling
K	0007283	biological_process	spermatogenesis
K	0007507	biological_process	heart development
K	0008013	molecular_function	beta-catenin binding
K	0008104	biological_process	protein localization
K	0010628	biological_process	positive regulation of gene expression
K	0010644	biological_process	cell communication by electrical coupling
K	0014047	biological_process	glutamate secretion
K	0014704	cellular_component	intercalated disc
K	0015075	molecular_function	monoatomic ion transmembrane transporter activity
K	0015562	molecular_function	efflux transmembrane transporter activity
K	0015631	molecular_function	tubulin binding
K	0016020	cellular_component	membrane
K	0016264	biological_process	gap junction assembly
K	0016324	cellular_component	apical plasma membrane
K	0022857	molecular_function	transmembrane transporter activity
K	0030054	cellular_component	cell junction
K	0030308	biological_process	negative regulation of cell growth
K	0030660	cellular_component	Golgi-associated vesicle membrane
K	0032277	biological_process	negative regulation of gonadotropin secretion
K	0034220	biological_process	monoatomic ion transmembrane transport
K	0034634	molecular_function	glutathione transmembrane transporter activity
K	0034775	biological_process	glutathione transmembrane transport
K	0035633	biological_process	maintenance of blood-brain barrier
K	0042908	biological_process	xenobiotic transport
K	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
K	0044291	cellular_component	cell-cell contact zone
K	0045121	cellular_component	membrane raft
K	0045216	biological_process	cell-cell junction organization
K	0046849	biological_process	bone remodeling
K	0055077	molecular_function	gap junction hemi-channel activity
K	0060348	biological_process	bone development
K	0070160	cellular_component	tight junction
K	0070161	cellular_component	anchoring junction
K	0086014	biological_process	atrial cardiac muscle cell action potential
K	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
K	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
K	0120162	biological_process	positive regulation of cold-induced thermogenesis
K	0140115	biological_process	export across plasma membrane
K	1901164	biological_process	negative regulation of trophoblast cell migration
K	1903522	biological_process	regulation of blood circulation
K	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
K	1904646	biological_process	cellular response to amyloid-beta
K	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
K	1905332	biological_process	positive regulation of morphogenesis of an epithelium
K	1905772	biological_process	positive regulation of mesodermal cell differentiation
K	2000648	biological_process	positive regulation of stem cell proliferation
L	0000132	biological_process	establishment of mitotic spindle orientation
L	0000139	cellular_component	Golgi membrane
L	0003161	biological_process	cardiac conduction system development
L	0005243	molecular_function	gap junction channel activity
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005794	cellular_component	Golgi apparatus
L	0005886	cellular_component	plasma membrane
L	0005921	cellular_component	gap junction
L	0005922	cellular_component	connexin complex
L	0005925	cellular_component	focal adhesion
L	0007154	biological_process	cell communication
L	0007165	biological_process	signal transduction
L	0007267	biological_process	cell-cell signaling
L	0007283	biological_process	spermatogenesis
L	0007507	biological_process	heart development
L	0008013	molecular_function	beta-catenin binding
L	0008104	biological_process	protein localization
L	0010628	biological_process	positive regulation of gene expression
L	0010644	biological_process	cell communication by electrical coupling
L	0014047	biological_process	glutamate secretion
L	0014704	cellular_component	intercalated disc
L	0015075	molecular_function	monoatomic ion transmembrane transporter activity
L	0015562	molecular_function	efflux transmembrane transporter activity
L	0015631	molecular_function	tubulin binding
L	0016020	cellular_component	membrane
L	0016264	biological_process	gap junction assembly
L	0016324	cellular_component	apical plasma membrane
L	0022857	molecular_function	transmembrane transporter activity
L	0030054	cellular_component	cell junction
L	0030308	biological_process	negative regulation of cell growth
L	0030660	cellular_component	Golgi-associated vesicle membrane
L	0032277	biological_process	negative regulation of gonadotropin secretion
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0034634	molecular_function	glutathione transmembrane transporter activity
L	0034775	biological_process	glutathione transmembrane transport
L	0035633	biological_process	maintenance of blood-brain barrier
L	0042908	biological_process	xenobiotic transport
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0044291	cellular_component	cell-cell contact zone
L	0045121	cellular_component	membrane raft
L	0045216	biological_process	cell-cell junction organization
L	0046849	biological_process	bone remodeling
L	0055077	molecular_function	gap junction hemi-channel activity
L	0060348	biological_process	bone development
L	0070160	cellular_component	tight junction
L	0070161	cellular_component	anchoring junction
L	0086014	biological_process	atrial cardiac muscle cell action potential
L	0086064	biological_process	cell communication by electrical coupling involved in cardiac conduction
L	0086075	molecular_function	gap junction channel activity involved in cardiac conduction electrical coupling
L	0120162	biological_process	positive regulation of cold-induced thermogenesis
L	0140115	biological_process	export across plasma membrane
L	1901164	biological_process	negative regulation of trophoblast cell migration
L	1903522	biological_process	regulation of blood circulation
L	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
L	1904646	biological_process	cellular response to amyloid-beta
L	1904707	biological_process	positive regulation of vascular associated smooth muscle cell proliferation
L	1905332	biological_process	positive regulation of morphogenesis of an epithelium
L	1905772	biological_process	positive regulation of mesodermal cell differentiation
L	2000648	biological_process	positive regulation of stem cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD

Chain	Residue	Details
A	CYS54-ASP67

---

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Ckrd.PCphqVDCFLSRP

Chain	Residue	Details
A	CYS187-PRO203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	960
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	732
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08050","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---