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7Z22

Connexin43 gap junction channel structure in nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0000132biological_processestablishment of mitotic spindle orientation
A0000139cellular_componentGolgi membrane
A0001649biological_processosteoblast differentiation
A0001701biological_processin utero embryonic development
A0001764biological_processneuron migration
A0001947biological_processheart looping
A0002069biological_processcolumnar/cuboidal epithelial cell maturation
A0002088biological_processlens development in camera-type eye
A0003161biological_processcardiac conduction system development
A0003294biological_processatrial ventricular junction remodeling
A0005102molecular_functionsignaling receptor binding
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005882cellular_componentintermediate filament
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005916cellular_componentfascia adherens
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0005925cellular_componentfocal adhesion
A0007154biological_processcell communication
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007283biological_processspermatogenesis
A0007507biological_processheart development
A0007512biological_processadult heart development
A0008013molecular_functionbeta-catenin binding
A0008016biological_processregulation of heart contraction
A0008104biological_processprotein localization
A0008584biological_processmale gonad development
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010643biological_processcell communication by chemical coupling
A0010644biological_processcell communication by electrical coupling
A0014047biological_processglutamate secretion
A0014704cellular_componentintercalated disc
A0015075molecular_functionmonoatomic ion transmembrane transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015631molecular_functiontubulin binding
A0016020cellular_componentmembrane
A0016264biological_processgap junction assembly
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0022857molecular_functiontransmembrane transporter activity
A0030054cellular_componentcell junction
A0030308biological_processnegative regulation of cell growth
A0030500biological_processregulation of bone mineralization
A0030660cellular_componentGolgi-associated vesicle membrane
A0032277biological_processnegative regulation of gonadotropin secretion
A0034220biological_processmonoatomic ion transmembrane transport
A0034634molecular_functionglutathione transmembrane transporter activity
A0034775biological_processglutathione transmembrane transport
A0035050biological_processembryonic heart tube development
A0035633biological_processmaintenance of blood-brain barrier
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042733biological_processembryonic digit morphogenesis
A0042908biological_processxenobiotic transport
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0043292cellular_componentcontractile muscle fiber
A0043403biological_processskeletal muscle tissue regeneration
A0044291cellular_componentcell-cell contact zone
A0045121cellular_componentmembrane raft
A0045216biological_processcell-cell junction organization
A0045844biological_processpositive regulation of striated muscle tissue development
A0046849biological_processbone remodeling
A0046850biological_processregulation of bone remodeling
A0048487molecular_functionbeta-tubulin binding
A0048514biological_processblood vessel morphogenesis
A0055077molecular_functiongap junction hemi-channel activity
A0060156biological_processmilk ejection reflex
A0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
A0060348biological_processbone development
A0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
A0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
A0061337biological_processcardiac conduction
A0070160cellular_componenttight junction
A0071467biological_processcellular response to pH
A0086014biological_processatrial cardiac muscle cell action potential
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
A0097110molecular_functionscaffold protein binding
A0097402biological_processneuroblast migration
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140115biological_processexport across plasma membrane
A1901164biological_processnegative regulation of trophoblast cell migration
A1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
A1904646biological_processcellular response to amyloid-beta
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A1905332biological_processpositive regulation of morphogenesis of an epithelium
A1905772biological_processpositive regulation of mesodermal cell differentiation
A1990782molecular_functionprotein tyrosine kinase binding
A2000648biological_processpositive regulation of stem cell proliferation
B0000132biological_processestablishment of mitotic spindle orientation
B0000139cellular_componentGolgi membrane
B0001649biological_processosteoblast differentiation
B0001701biological_processin utero embryonic development
B0001764biological_processneuron migration
B0001947biological_processheart looping
B0002069biological_processcolumnar/cuboidal epithelial cell maturation
B0002088biological_processlens development in camera-type eye
B0003161biological_processcardiac conduction system development
B0003294biological_processatrial ventricular junction remodeling
B0005102molecular_functionsignaling receptor binding
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005882cellular_componentintermediate filament
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005916cellular_componentfascia adherens
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0005925cellular_componentfocal adhesion
B0007154biological_processcell communication
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007283biological_processspermatogenesis
B0007507biological_processheart development
B0007512biological_processadult heart development
B0008013molecular_functionbeta-catenin binding
B0008016biological_processregulation of heart contraction
B0008104biological_processprotein localization
B0008584biological_processmale gonad development
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010643biological_processcell communication by chemical coupling
B0010644biological_processcell communication by electrical coupling
B0014047biological_processglutamate secretion
B0014704cellular_componentintercalated disc
B0015075molecular_functionmonoatomic ion transmembrane transporter activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015631molecular_functiontubulin binding
B0016020cellular_componentmembrane
B0016264biological_processgap junction assembly
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0022857molecular_functiontransmembrane transporter activity
B0030054cellular_componentcell junction
B0030308biological_processnegative regulation of cell growth
B0030500biological_processregulation of bone mineralization
B0030660cellular_componentGolgi-associated vesicle membrane
B0032277biological_processnegative regulation of gonadotropin secretion
B0034220biological_processmonoatomic ion transmembrane transport
B0034634molecular_functionglutathione transmembrane transporter activity
B0034775biological_processglutathione transmembrane transport
B0035050biological_processembryonic heart tube development
B0035633biological_processmaintenance of blood-brain barrier
B0042098biological_processT cell proliferation
B0042110biological_processT cell activation
B0042733biological_processembryonic digit morphogenesis
B0042908biological_processxenobiotic transport
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0043292cellular_componentcontractile muscle fiber
B0043403biological_processskeletal muscle tissue regeneration
B0044291cellular_componentcell-cell contact zone
B0045121cellular_componentmembrane raft
B0045216biological_processcell-cell junction organization
B0045844biological_processpositive regulation of striated muscle tissue development
B0046849biological_processbone remodeling
B0046850biological_processregulation of bone remodeling
B0048487molecular_functionbeta-tubulin binding
B0048514biological_processblood vessel morphogenesis
B0055077molecular_functiongap junction hemi-channel activity
B0060156biological_processmilk ejection reflex
B0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
B0060348biological_processbone development
B0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
B0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
B0061337biological_processcardiac conduction
B0070160cellular_componenttight junction
B0071467biological_processcellular response to pH
B0086014biological_processatrial cardiac muscle cell action potential
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
B0097110molecular_functionscaffold protein binding
B0097402biological_processneuroblast migration
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0140115biological_processexport across plasma membrane
B1901164biological_processnegative regulation of trophoblast cell migration
B1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
B1904646biological_processcellular response to amyloid-beta
B1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
B1905332biological_processpositive regulation of morphogenesis of an epithelium
B1905772biological_processpositive regulation of mesodermal cell differentiation
B1990782molecular_functionprotein tyrosine kinase binding
B2000648biological_processpositive regulation of stem cell proliferation
C0000132biological_processestablishment of mitotic spindle orientation
C0000139cellular_componentGolgi membrane
C0001649biological_processosteoblast differentiation
C0001701biological_processin utero embryonic development
C0001764biological_processneuron migration
C0001947biological_processheart looping
C0002069biological_processcolumnar/cuboidal epithelial cell maturation
C0002088biological_processlens development in camera-type eye
C0003161biological_processcardiac conduction system development
C0003294biological_processatrial ventricular junction remodeling
C0005102molecular_functionsignaling receptor binding
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005882cellular_componentintermediate filament
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005916cellular_componentfascia adherens
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0005925cellular_componentfocal adhesion
C0007154biological_processcell communication
C0007165biological_processsignal transduction
C0007267biological_processcell-cell signaling
C0007283biological_processspermatogenesis
C0007507biological_processheart development
C0007512biological_processadult heart development
C0008013molecular_functionbeta-catenin binding
C0008016biological_processregulation of heart contraction
C0008104biological_processprotein localization
C0008584biological_processmale gonad development
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010643biological_processcell communication by chemical coupling
C0010644biological_processcell communication by electrical coupling
C0014047biological_processglutamate secretion
C0014704cellular_componentintercalated disc
C0015075molecular_functionmonoatomic ion transmembrane transporter activity
C0015562molecular_functionefflux transmembrane transporter activity
C0015631molecular_functiontubulin binding
C0016020cellular_componentmembrane
C0016264biological_processgap junction assembly
C0016324cellular_componentapical plasma membrane
C0016328cellular_componentlateral plasma membrane
C0022857molecular_functiontransmembrane transporter activity
C0030054cellular_componentcell junction
C0030308biological_processnegative regulation of cell growth
C0030500biological_processregulation of bone mineralization
C0030660cellular_componentGolgi-associated vesicle membrane
C0032277biological_processnegative regulation of gonadotropin secretion
C0034220biological_processmonoatomic ion transmembrane transport
C0034634molecular_functionglutathione transmembrane transporter activity
C0034775biological_processglutathione transmembrane transport
C0035050biological_processembryonic heart tube development
C0035633biological_processmaintenance of blood-brain barrier
C0042098biological_processT cell proliferation
C0042110biological_processT cell activation
C0042733biological_processembryonic digit morphogenesis
C0042908biological_processxenobiotic transport
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043231cellular_componentintracellular membrane-bounded organelle
C0043292cellular_componentcontractile muscle fiber
C0043403biological_processskeletal muscle tissue regeneration
C0044291cellular_componentcell-cell contact zone
C0045121cellular_componentmembrane raft
C0045216biological_processcell-cell junction organization
C0045844biological_processpositive regulation of striated muscle tissue development
C0046849biological_processbone remodeling
C0046850biological_processregulation of bone remodeling
C0048487molecular_functionbeta-tubulin binding
C0048514biological_processblood vessel morphogenesis
C0055077molecular_functiongap junction hemi-channel activity
C0060156biological_processmilk ejection reflex
C0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
C0060348biological_processbone development
C0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
C0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
C0061337biological_processcardiac conduction
C0070160cellular_componenttight junction
C0071467biological_processcellular response to pH
C0086014biological_processatrial cardiac muscle cell action potential
C0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
C0097110molecular_functionscaffold protein binding
C0097402biological_processneuroblast migration
C0120162biological_processpositive regulation of cold-induced thermogenesis
C0140115biological_processexport across plasma membrane
C1901164biological_processnegative regulation of trophoblast cell migration
C1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
C1904646biological_processcellular response to amyloid-beta
C1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
C1905332biological_processpositive regulation of morphogenesis of an epithelium
C1905772biological_processpositive regulation of mesodermal cell differentiation
C1990782molecular_functionprotein tyrosine kinase binding
C2000648biological_processpositive regulation of stem cell proliferation
D0000132biological_processestablishment of mitotic spindle orientation
D0000139cellular_componentGolgi membrane
D0001649biological_processosteoblast differentiation
D0001701biological_processin utero embryonic development
D0001764biological_processneuron migration
D0001947biological_processheart looping
D0002069biological_processcolumnar/cuboidal epithelial cell maturation
D0002088biological_processlens development in camera-type eye
D0003161biological_processcardiac conduction system development
D0003294biological_processatrial ventricular junction remodeling
D0005102molecular_functionsignaling receptor binding
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005882cellular_componentintermediate filament
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005916cellular_componentfascia adherens
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0005925cellular_componentfocal adhesion
D0007154biological_processcell communication
D0007165biological_processsignal transduction
D0007267biological_processcell-cell signaling
D0007283biological_processspermatogenesis
D0007507biological_processheart development
D0007512biological_processadult heart development
D0008013molecular_functionbeta-catenin binding
D0008016biological_processregulation of heart contraction
D0008104biological_processprotein localization
D0008584biological_processmale gonad development
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010643biological_processcell communication by chemical coupling
D0010644biological_processcell communication by electrical coupling
D0014047biological_processglutamate secretion
D0014704cellular_componentintercalated disc
D0015075molecular_functionmonoatomic ion transmembrane transporter activity
D0015562molecular_functionefflux transmembrane transporter activity
D0015631molecular_functiontubulin binding
D0016020cellular_componentmembrane
D0016264biological_processgap junction assembly
D0016324cellular_componentapical plasma membrane
D0016328cellular_componentlateral plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0030054cellular_componentcell junction
D0030308biological_processnegative regulation of cell growth
D0030500biological_processregulation of bone mineralization
D0030660cellular_componentGolgi-associated vesicle membrane
D0032277biological_processnegative regulation of gonadotropin secretion
D0034220biological_processmonoatomic ion transmembrane transport
D0034634molecular_functionglutathione transmembrane transporter activity
D0034775biological_processglutathione transmembrane transport
D0035050biological_processembryonic heart tube development
D0035633biological_processmaintenance of blood-brain barrier
D0042098biological_processT cell proliferation
D0042110biological_processT cell activation
D0042733biological_processembryonic digit morphogenesis
D0042908biological_processxenobiotic transport
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043231cellular_componentintracellular membrane-bounded organelle
D0043292cellular_componentcontractile muscle fiber
D0043403biological_processskeletal muscle tissue regeneration
D0044291cellular_componentcell-cell contact zone
D0045121cellular_componentmembrane raft
D0045216biological_processcell-cell junction organization
D0045844biological_processpositive regulation of striated muscle tissue development
D0046849biological_processbone remodeling
D0046850biological_processregulation of bone remodeling
D0048487molecular_functionbeta-tubulin binding
D0048514biological_processblood vessel morphogenesis
D0055077molecular_functiongap junction hemi-channel activity
D0060156biological_processmilk ejection reflex
D0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
D0060348biological_processbone development
D0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
D0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
D0061337biological_processcardiac conduction
D0070160cellular_componenttight junction
D0071467biological_processcellular response to pH
D0086014biological_processatrial cardiac muscle cell action potential
D0086064biological_processcell communication by electrical coupling involved in cardiac conduction
D0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
D0097110molecular_functionscaffold protein binding
D0097402biological_processneuroblast migration
D0120162biological_processpositive regulation of cold-induced thermogenesis
D0140115biological_processexport across plasma membrane
D1901164biological_processnegative regulation of trophoblast cell migration
D1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
D1904646biological_processcellular response to amyloid-beta
D1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
D1905332biological_processpositive regulation of morphogenesis of an epithelium
D1905772biological_processpositive regulation of mesodermal cell differentiation
D1990782molecular_functionprotein tyrosine kinase binding
D2000648biological_processpositive regulation of stem cell proliferation
E0000132biological_processestablishment of mitotic spindle orientation
E0000139cellular_componentGolgi membrane
E0001649biological_processosteoblast differentiation
E0001701biological_processin utero embryonic development
E0001764biological_processneuron migration
E0001947biological_processheart looping
E0002069biological_processcolumnar/cuboidal epithelial cell maturation
E0002088biological_processlens development in camera-type eye
E0003161biological_processcardiac conduction system development
E0003294biological_processatrial ventricular junction remodeling
E0005102molecular_functionsignaling receptor binding
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0005882cellular_componentintermediate filament
E0005886cellular_componentplasma membrane
E0005911cellular_componentcell-cell junction
E0005916cellular_componentfascia adherens
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0005925cellular_componentfocal adhesion
E0007154biological_processcell communication
E0007165biological_processsignal transduction
E0007267biological_processcell-cell signaling
E0007283biological_processspermatogenesis
E0007507biological_processheart development
E0007512biological_processadult heart development
E0008013molecular_functionbeta-catenin binding
E0008016biological_processregulation of heart contraction
E0008104biological_processprotein localization
E0008584biological_processmale gonad development
E0010628biological_processpositive regulation of gene expression
E0010629biological_processnegative regulation of gene expression
E0010643biological_processcell communication by chemical coupling
E0010644biological_processcell communication by electrical coupling
E0014047biological_processglutamate secretion
E0014704cellular_componentintercalated disc
E0015075molecular_functionmonoatomic ion transmembrane transporter activity
E0015562molecular_functionefflux transmembrane transporter activity
E0015631molecular_functiontubulin binding
E0016020cellular_componentmembrane
E0016264biological_processgap junction assembly
E0016324cellular_componentapical plasma membrane
E0016328cellular_componentlateral plasma membrane
E0022857molecular_functiontransmembrane transporter activity
E0030054cellular_componentcell junction
E0030308biological_processnegative regulation of cell growth
E0030500biological_processregulation of bone mineralization
E0030660cellular_componentGolgi-associated vesicle membrane
E0032277biological_processnegative regulation of gonadotropin secretion
E0034220biological_processmonoatomic ion transmembrane transport
E0034634molecular_functionglutathione transmembrane transporter activity
E0034775biological_processglutathione transmembrane transport
E0035050biological_processembryonic heart tube development
E0035633biological_processmaintenance of blood-brain barrier
E0042098biological_processT cell proliferation
E0042110biological_processT cell activation
E0042733biological_processembryonic digit morphogenesis
E0042908biological_processxenobiotic transport
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043231cellular_componentintracellular membrane-bounded organelle
E0043292cellular_componentcontractile muscle fiber
E0043403biological_processskeletal muscle tissue regeneration
E0044291cellular_componentcell-cell contact zone
E0045121cellular_componentmembrane raft
E0045216biological_processcell-cell junction organization
E0045844biological_processpositive regulation of striated muscle tissue development
E0046849biological_processbone remodeling
E0046850biological_processregulation of bone remodeling
E0048487molecular_functionbeta-tubulin binding
E0048514biological_processblood vessel morphogenesis
E0055077molecular_functiongap junction hemi-channel activity
E0060156biological_processmilk ejection reflex
E0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
E0060348biological_processbone development
E0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
E0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
E0061337biological_processcardiac conduction
E0070160cellular_componenttight junction
E0071467biological_processcellular response to pH
E0086014biological_processatrial cardiac muscle cell action potential
E0086064biological_processcell communication by electrical coupling involved in cardiac conduction
E0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
E0097110molecular_functionscaffold protein binding
E0097402biological_processneuroblast migration
E0120162biological_processpositive regulation of cold-induced thermogenesis
E0140115biological_processexport across plasma membrane
E1901164biological_processnegative regulation of trophoblast cell migration
E1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
E1904646biological_processcellular response to amyloid-beta
E1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
E1905332biological_processpositive regulation of morphogenesis of an epithelium
E1905772biological_processpositive regulation of mesodermal cell differentiation
E1990782molecular_functionprotein tyrosine kinase binding
E2000648biological_processpositive regulation of stem cell proliferation
F0000132biological_processestablishment of mitotic spindle orientation
F0000139cellular_componentGolgi membrane
F0001649biological_processosteoblast differentiation
F0001701biological_processin utero embryonic development
F0001764biological_processneuron migration
F0001947biological_processheart looping
F0002069biological_processcolumnar/cuboidal epithelial cell maturation
F0002088biological_processlens development in camera-type eye
F0003161biological_processcardiac conduction system development
F0003294biological_processatrial ventricular junction remodeling
F0005102molecular_functionsignaling receptor binding
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005882cellular_componentintermediate filament
F0005886cellular_componentplasma membrane
F0005911cellular_componentcell-cell junction
F0005916cellular_componentfascia adherens
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0005925cellular_componentfocal adhesion
F0007154biological_processcell communication
F0007165biological_processsignal transduction
F0007267biological_processcell-cell signaling
F0007283biological_processspermatogenesis
F0007507biological_processheart development
F0007512biological_processadult heart development
F0008013molecular_functionbeta-catenin binding
F0008016biological_processregulation of heart contraction
F0008104biological_processprotein localization
F0008584biological_processmale gonad development
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0010643biological_processcell communication by chemical coupling
F0010644biological_processcell communication by electrical coupling
F0014047biological_processglutamate secretion
F0014704cellular_componentintercalated disc
F0015075molecular_functionmonoatomic ion transmembrane transporter activity
F0015562molecular_functionefflux transmembrane transporter activity
F0015631molecular_functiontubulin binding
F0016020cellular_componentmembrane
F0016264biological_processgap junction assembly
F0016324cellular_componentapical plasma membrane
F0016328cellular_componentlateral plasma membrane
F0022857molecular_functiontransmembrane transporter activity
F0030054cellular_componentcell junction
F0030308biological_processnegative regulation of cell growth
F0030500biological_processregulation of bone mineralization
F0030660cellular_componentGolgi-associated vesicle membrane
F0032277biological_processnegative regulation of gonadotropin secretion
F0034220biological_processmonoatomic ion transmembrane transport
F0034634molecular_functionglutathione transmembrane transporter activity
F0034775biological_processglutathione transmembrane transport
F0035050biological_processembryonic heart tube development
F0035633biological_processmaintenance of blood-brain barrier
F0042098biological_processT cell proliferation
F0042110biological_processT cell activation
F0042733biological_processembryonic digit morphogenesis
F0042908biological_processxenobiotic transport
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043231cellular_componentintracellular membrane-bounded organelle
F0043292cellular_componentcontractile muscle fiber
F0043403biological_processskeletal muscle tissue regeneration
F0044291cellular_componentcell-cell contact zone
F0045121cellular_componentmembrane raft
F0045216biological_processcell-cell junction organization
F0045844biological_processpositive regulation of striated muscle tissue development
F0046849biological_processbone remodeling
F0046850biological_processregulation of bone remodeling
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L0022857molecular_functiontransmembrane transporter activity
L0030054cellular_componentcell junction
L0030308biological_processnegative regulation of cell growth
L0030500biological_processregulation of bone mineralization
L0030660cellular_componentGolgi-associated vesicle membrane
L0032277biological_processnegative regulation of gonadotropin secretion
L0034220biological_processmonoatomic ion transmembrane transport
L0034634molecular_functionglutathione transmembrane transporter activity
L0034775biological_processglutathione transmembrane transport
L0035050biological_processembryonic heart tube development
L0035633biological_processmaintenance of blood-brain barrier
L0042098biological_processT cell proliferation
L0042110biological_processT cell activation
L0042733biological_processembryonic digit morphogenesis
L0042908biological_processxenobiotic transport
L0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
L0043231cellular_componentintracellular membrane-bounded organelle
L0043292cellular_componentcontractile muscle fiber
L0043403biological_processskeletal muscle tissue regeneration
L0044291cellular_componentcell-cell contact zone
L0045121cellular_componentmembrane raft
L0045216biological_processcell-cell junction organization
L0045844biological_processpositive regulation of striated muscle tissue development
L0046849biological_processbone remodeling
L0046850biological_processregulation of bone remodeling
L0048487molecular_functionbeta-tubulin binding
L0048514biological_processblood vessel morphogenesis
L0055077molecular_functiongap junction hemi-channel activity
L0060156biological_processmilk ejection reflex
L0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
L0060348biological_processbone development
L0060371biological_processregulation of atrial cardiac muscle cell membrane depolarization
L0060373biological_processregulation of ventricular cardiac muscle cell membrane depolarization
L0061337biological_processcardiac conduction
L0070160cellular_componenttight junction
L0071467biological_processcellular response to pH
L0086014biological_processatrial cardiac muscle cell action potential
L0086064biological_processcell communication by electrical coupling involved in cardiac conduction
L0086075molecular_functiongap junction channel activity involved in cardiac conduction electrical coupling
L0097110molecular_functionscaffold protein binding
L0097402biological_processneuroblast migration
L0120162biological_processpositive regulation of cold-induced thermogenesis
L0140115biological_processexport across plasma membrane
L1901164biological_processnegative regulation of trophoblast cell migration
L1903763molecular_functiongap junction channel activity involved in cell communication by electrical coupling
L1904646biological_processcellular response to amyloid-beta
L1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
L1905332biological_processpositive regulation of morphogenesis of an epithelium
L1905772biological_processpositive regulation of mesodermal cell differentiation
L1990782molecular_functionprotein tyrosine kinase binding
L2000648biological_processpositive regulation of stem cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD
ChainResidueDetails
ACYS54-ASP67

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Ckrd.PCphqVDCFLSRP
ChainResidueDetails
ACYS187-PRO203

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2772
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P08050
ChainResidueDetails
AGLY2-LYS23
DGLY2-LYS23
DTYR98-TYR155
DPHE229-ILE382
EGLY2-LYS23
ETYR98-TYR155
EPHE229-ILE382
FGLY2-LYS23
FTYR98-TYR155
FPHE229-ILE382
GGLY2-LYS23
ATYR98-TYR155
GTYR98-TYR155
GPHE229-ILE382
HGLY2-LYS23
HTYR98-TYR155
HPHE229-ILE382
IGLY2-LYS23
ITYR98-TYR155
IPHE229-ILE382
JGLY2-LYS23
JTYR98-TYR155
APHE229-ILE382
JPHE229-ILE382
KGLY2-LYS23
KTYR98-TYR155
KPHE229-ILE382
LGLY2-LYS23
LTYR98-TYR155
LPHE229-ILE382
BGLY2-LYS23
BTYR98-TYR155
BPHE229-ILE382
CGLY2-LYS23
CTYR98-TYR155
CPHE229-ILE382

site_idSWS_FT_FI2
Number of Residues960
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AVAL24-ALA44
CPHE77-PHE97
CILE156-ILE176
CILE208-LEU228
DVAL24-ALA44
DPHE77-PHE97
DILE156-ILE176
DILE208-LEU228
EVAL24-ALA44
EPHE77-PHE97
EILE156-ILE176
APHE77-PHE97
EILE208-LEU228
FVAL24-ALA44
FPHE77-PHE97
FILE156-ILE176
FILE208-LEU228
GVAL24-ALA44
GPHE77-PHE97
GILE156-ILE176
GILE208-LEU228
HVAL24-ALA44
AILE156-ILE176
HPHE77-PHE97
HILE156-ILE176
HILE208-LEU228
IVAL24-ALA44
IPHE77-PHE97
IILE156-ILE176
IILE208-LEU228
JVAL24-ALA44
JPHE77-PHE97
JILE156-ILE176
AILE208-LEU228
JILE208-LEU228
KVAL24-ALA44
KPHE77-PHE97
KILE156-ILE176
KILE208-LEU228
LVAL24-ALA44
LPHE77-PHE97
LILE156-ILE176
LILE208-LEU228
BVAL24-ALA44
BPHE77-PHE97
BILE156-ILE176
BILE208-LEU228
CVAL24-ALA44

site_idSWS_FT_FI3
Number of Residues732
DetailsTOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P08050
ChainResidueDetails
ATRP45-ARG76
ETYR177-THR207
FTRP45-ARG76
FTYR177-THR207
GTRP45-ARG76
GTYR177-THR207
HTRP45-ARG76
HTYR177-THR207
ITRP45-ARG76
ITYR177-THR207
JTRP45-ARG76
ATYR177-THR207
JTYR177-THR207
KTRP45-ARG76
KTYR177-THR207
LTRP45-ARG76
LTYR177-THR207
BTRP45-ARG76
BTYR177-THR207
CTRP45-ARG76
CTYR177-THR207
DTRP45-ARG76
DTYR177-THR207
ETRP45-ARG76

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08050
ChainResidueDetails
ASER5
ESER373
FSER5
FSER373
GSER5
GSER373
HSER5
HSER373
ISER5
ISER373
JSER5
ASER373
JSER373
KSER5
KSER373
LSER5
LSER373
BSER5
BSER373
CSER5
CSER373
DSER5
DSER373
ESER5

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P23242
ChainResidueDetails
ATYR247
JTYR247
KTYR247
LTYR247
BTYR247
CTYR247
DTYR247
ETYR247
FTYR247
GTYR247
HTYR247
ITYR247

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15605363, ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER255
JSER255
KSER255
LSER255
BSER255
CSER255
DSER255
ESER255
FSER255
GSER255
HSER255
ISER255

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:14702389, ECO:0000269|PubMed:15605363
ChainResidueDetails
ASER262
JSER262
KSER262
LSER262
BSER262
CSER262
DSER262
ESER262
FSER262
GSER262
HSER262
ISER262

site_idSWS_FT_FI8
Number of Residues12
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P23242
ChainResidueDetails
ACYS271
JCYS271
KCYS271
LCYS271
BCYS271
CCYS271
DCYS271
ECYS271
FCYS271
GCYS271
HCYS271
ICYS271

site_idSWS_FT_FI9
Number of Residues24
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P23242
ChainResidueDetails
ATHR275
ETHR326
FTHR275
FTHR326
GTHR275
GTHR326
HTHR275
HTHR326
ITHR275
ITHR326
JTHR275
ATHR326
JTHR326
KTHR275
KTHR326
LTHR275
LTHR326
BTHR275
BTHR326
CTHR275
CTHR326
DTHR275
DTHR326
ETHR275

site_idSWS_FT_FI10
Number of Residues36
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23242
ChainResidueDetails
ASER306
DSER306
DSER365
DSER369
ESER306
ESER365
ESER369
FSER306
FSER365
FSER369
GSER306
ASER365
GSER365
GSER369
HSER306
HSER365
HSER369
ISER306
ISER365
ISER369
JSER306
JSER365
ASER369
JSER369
KSER306
KSER365
KSER369
LSER306
LSER365
LSER369
BSER306
BSER365
BSER369
CSER306
CSER365
CSER369

site_idSWS_FT_FI11
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER314
ESER344
FSER314
FSER344
GSER314
GSER344
HSER314
HSER344
ISER314
ISER344
JSER314
ASER344
JSER344
KSER314
KSER344
LSER314
LSER344
BSER314
BSER344
CSER314
CSER344
DSER314
DSER344
ESER314

site_idSWS_FT_FI12
Number of Residues36
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:12270943
ChainResidueDetails
ASER325
DSER325
DSER328
DSER330
ESER325
ESER328
ESER330
FSER325
FSER328
FSER330
GSER325
ASER328
GSER328
GSER330
HSER325
HSER328
HSER330
ISER325
ISER328
ISER330
JSER325
JSER328
ASER330
JSER330
KSER325
KSER328
KSER330
LSER325
LSER328
LSER330
BSER325
BSER328
BSER330
CSER325
CSER328
CSER330

site_idSWS_FT_FI13
Number of Residues12
DetailsMOD_RES: Phosphoserine; by PKC/PRKCG and PKC/PRKCD => ECO:0000250|UniProtKB:P23242
ChainResidueDetails
ASER368
JSER368
KSER368
LSER368
BSER368
CSER368
DSER368
ESER368
FSER368
GSER368
HSER368
ISER368

site_idSWS_FT_FI14
Number of Residues36
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:22411987
ChainResidueDetails
ALYS144
DLYS144
DLYS237
ELYS144
ELYS237
FLYS144
FLYS237
GLYS144
GLYS237
HLYS144
HLYS237
ILYS144
ILYS237
JLYS144
ALYS237
JLYS237
KLYS144
KLYS237
LLYS144
LLYS237
BLYS144
BLYS237
CLYS144
CLYS237

227344

PDB entries from 2024-11-13

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