7Z10

Monomeric respiratory complex IV isolated from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0022904	biological_process	respiratory electron transport chain
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	1902600	biological_process	proton transmembrane transport
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0022904	biological_process	respiratory electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0045277	cellular_component	respiratory chain complex IV
b	0046872	molecular_function	metal ion binding
b	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045277	cellular_component	respiratory chain complex IV
c	0045333	biological_process	cellular respiration
c	0048039	molecular_function	ubiquinone binding
c	1902600	biological_process	proton transmembrane transport
d	0005740	cellular_component	mitochondrial envelope
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
d	0045277	cellular_component	respiratory chain complex IV
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0045277	cellular_component	respiratory chain complex IV
f	0005743	cellular_component	mitochondrial inner membrane
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0045277	cellular_component	respiratory chain complex IV
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045277	cellular_component	respiratory chain complex IV
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
h	0045277	cellular_component	respiratory chain complex IV
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016491	molecular_function	oxidoreductase activity
i	0045277	cellular_component	respiratory chain complex IV
i	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

---

site_id	AC2
Number of Residues	27
Details	binding site for residue HEA a 602

Chain	Residue
a	VAL59
a	HIS62
a	ALA63
a	MET66
a	TRP127
a	TYR371
a	PHE377
a	HIS378
a	LEU381
a	SER382
a	ILE386
a	LEU389
a	PHE390
a	ILE424
a	PHE425
a	MET428
a	ARG438
a	ARG439
a	ALA461
a	LEU465
a	PHE468
a	PHE19
a	ILE23
a	GLY26
a	THR30
a	SER33
a	ARG37

---

site_id	AC3
Number of Residues	22
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP127
a	TRP237
a	VAL244
a	TYR245
a	HIS290
a	THR309
a	THR316
a	GLY317
a	GLY352
a	GLY355
a	VAL356
a	ALA359
a	HIS368
a	VAL373
a	HIS376
a	PHE377
a	VAL380
a	LEU381
a	ARG438
b	ILE50
b	PRO89
b	LEU93

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG a 604

Chain	Residue
a	HIS368
a	ASP369
b	GLU223

---

site_id	AC5
Number of Residues	11
Details	binding site for residue PEF a 605

Chain	Residue
a	PHE95
a	PRO96
a	ARG97
a	ILE98
c	HIS15
c	TRP65
c	PHE66
c	ILE69
c	HIS79
c	PHE94
c	PEF301

---

site_id	AC6
Number of Residues	9
Details	binding site for residue PEF a 606

Chain	Residue
a	LEU17
a	PHE19
a	MET20
a	ILE400
h	PRO39
h	PHE40
h	ARG45
h	HIS53
h	PHE56

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	MET232

---

site_id	AC8
Number of Residues	16
Details	binding site for residue PEF c 301

Chain	Residue
a	PEF605
c	PHE66
c	ILE69
c	VAL70
c	THR74
c	ILE87
c	PHE91
c	MET222
c	VAL225
c	ARG229
c	HIS234
c	THR236
c	HIS239
c	VAL241
c	GLY242
d	GLU63

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN d 201

Chain	Residue
d	CYS134
d	CYS137
d	CYS111
d	HIS119

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
a	TRP237-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
b	VAL184-MET232

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
d	ILE121-LEU143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	290
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	75
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	337
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	86
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	53
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	51
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	41
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598556","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598556","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17215247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	101
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---