Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7YZR

50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002028biological_processregulation of sodium ion transport
A0005215molecular_functiontransporter activity
A0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005886cellular_componentplasma membrane
A0005890cellular_componentsodium:potassium-exchanging ATPase complex
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006883biological_processintracellular sodium ion homeostasis
A0008556molecular_functionP-type potassium transmembrane transporter activity
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0030007biological_processintracellular potassium ion homeostasis
A0030424cellular_componentaxon
A0030955molecular_functionpotassium ion binding
A0031402molecular_functionsodium ion binding
A0036376biological_processsodium ion export across plasma membrane
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0046872molecular_functionmetal ion binding
A0051117molecular_functionATPase binding
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0086009biological_processmembrane repolarization
A0090533cellular_componentcation-transporting ATPase complex
A0098797cellular_componentplasma membrane protein complex
A1902600biological_processproton transmembrane transport
A1990573biological_processpotassium ion import across plasma membrane
B0001671molecular_functionATPase activator activity
B0002376biological_processimmune system process
B0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005890cellular_componentsodium:potassium-exchanging ATPase complex
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006883biological_processintracellular sodium ion homeostasis
B0007155biological_processcell adhesion
B0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
B0010468biological_processregulation of gene expression
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014704cellular_componentintercalated disc
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016328cellular_componentlateral plasma membrane
B0019901molecular_functionprotein kinase binding
B0030007biological_processintracellular potassium ion homeostasis
B0030315cellular_componentT-tubule
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031090cellular_componentorganelle membrane
B0035725biological_processsodium ion transmembrane transport
B0036126cellular_componentsperm flagellum
B0036376biological_processsodium ion export across plasma membrane
B0042383cellular_componentsarcolemma
B0045087biological_processinnate immune response
B0046034biological_processATP metabolic process
B0050821biological_processprotein stabilization
B0051117molecular_functionATPase binding
B0055085biological_processtransmembrane transport
B0055119biological_processrelaxation of cardiac muscle
B0060048biological_processcardiac muscle contraction
B0072659biological_processprotein localization to plasma membrane
B0086009biological_processmembrane repolarization
B0141109molecular_functiontransporter activator activity
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1902307biological_processpositive regulation of sodium ion transmembrane transport
B1902600biological_processproton transmembrane transport
B1903169biological_processregulation of calcium ion transmembrane transport
B1903278biological_processpositive regulation of sodium ion export across plasma membrane
B1903288biological_processpositive regulation of potassium ion import across plasma membrane
B1990573biological_processpotassium ion import across plasma membrane
C0000166molecular_functionnucleotide binding
C0002028biological_processregulation of sodium ion transport
C0005215molecular_functiontransporter activity
C0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005886cellular_componentplasma membrane
C0005890cellular_componentsodium:potassium-exchanging ATPase complex
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0006883biological_processintracellular sodium ion homeostasis
C0008556molecular_functionP-type potassium transmembrane transporter activity
C0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016887molecular_functionATP hydrolysis activity
C0030007biological_processintracellular potassium ion homeostasis
C0030424cellular_componentaxon
C0030955molecular_functionpotassium ion binding
C0031402molecular_functionsodium ion binding
C0036376biological_processsodium ion export across plasma membrane
C0042383cellular_componentsarcolemma
C0042470cellular_componentmelanosome
C0042995cellular_componentcell projection
C0046872molecular_functionmetal ion binding
C0051117molecular_functionATPase binding
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0086009biological_processmembrane repolarization
C0090533cellular_componentcation-transporting ATPase complex
C0098797cellular_componentplasma membrane protein complex
C1902600biological_processproton transmembrane transport
C1990573biological_processpotassium ion import across plasma membrane
D0001671molecular_functionATPase activator activity
D0002376biological_processimmune system process
D0005391molecular_functionP-type sodium:potassium-exchanging transporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005890cellular_componentsodium:potassium-exchanging ATPase complex
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006883biological_processintracellular sodium ion homeostasis
D0007155biological_processcell adhesion
D0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
D0010468biological_processregulation of gene expression
D0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
D0014704cellular_componentintercalated disc
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016324cellular_componentapical plasma membrane
D0016328cellular_componentlateral plasma membrane
D0019901molecular_functionprotein kinase binding
D0030007biological_processintracellular potassium ion homeostasis
D0030315cellular_componentT-tubule
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031090cellular_componentorganelle membrane
D0035725biological_processsodium ion transmembrane transport
D0036126cellular_componentsperm flagellum
D0036376biological_processsodium ion export across plasma membrane
D0042383cellular_componentsarcolemma
D0045087biological_processinnate immune response
D0046034biological_processATP metabolic process
D0050821biological_processprotein stabilization
D0051117molecular_functionATPase binding
D0055085biological_processtransmembrane transport
D0055119biological_processrelaxation of cardiac muscle
D0060048biological_processcardiac muscle contraction
D0072659biological_processprotein localization to plasma membrane
D0086009biological_processmembrane repolarization
D0141109molecular_functiontransporter activator activity
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1902307biological_processpositive regulation of sodium ion transmembrane transport
D1902600biological_processproton transmembrane transport
D1903169biological_processregulation of calcium ion transmembrane transport
D1903278biological_processpositive regulation of sodium ion export across plasma membrane
D1903288biological_processpositive regulation of potassium ion import across plasma membrane
D1990573biological_processpotassium ion import across plasma membrane
E0001671molecular_functionATPase activator activity
E0005515molecular_functionprotein binding
E0005890cellular_componentsodium:potassium-exchanging ATPase complex
E0006811biological_processmonoatomic ion transport
E0006813biological_processpotassium ion transport
E0006814biological_processsodium ion transport
E0006883biological_processintracellular sodium ion homeostasis
E0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
E0016020cellular_componentmembrane
E0030007biological_processintracellular potassium ion homeostasis
E0030674molecular_functionprotein-macromolecule adaptor activity
E0036376biological_processsodium ion export across plasma membrane
E0043269biological_processregulation of monoatomic ion transport
E0055085biological_processtransmembrane transport
E0099106molecular_functionion channel regulator activity
E1902600biological_processproton transmembrane transport
E1990573biological_processpotassium ion import across plasma membrane
G0001671molecular_functionATPase activator activity
G0005515molecular_functionprotein binding
G0005890cellular_componentsodium:potassium-exchanging ATPase complex
G0006811biological_processmonoatomic ion transport
G0006813biological_processpotassium ion transport
G0006814biological_processsodium ion transport
G0006883biological_processintracellular sodium ion homeostasis
G0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
G0016020cellular_componentmembrane
G0030007biological_processintracellular potassium ion homeostasis
G0030674molecular_functionprotein-macromolecule adaptor activity
G0036376biological_processsodium ion export across plasma membrane
G0043269biological_processregulation of monoatomic ion transport
G0055085biological_processtransmembrane transport
G0099106molecular_functionion channel regulator activity
G1902600biological_processproton transmembrane transport
G1990573biological_processpotassium ion import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
AASP369-THR375
site_idPS00390
Number of Residues21
DetailsATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW
ChainResidueDetails
BTRP12-TRP32
site_idPS00391
Number of Residues16
DetailsATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfrlewLgnCSG
ChainResidueDetails
BARG146-GLY161
site_idPS01310
Number of Residues14
DetailsFXYD FXYD family signature. DpFyYDyeTVRngG
ChainResidueDetails
GASP17-GLY30
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues388
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues694
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1230
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsRegion: {"description":"Phosphoinositide-3 kinase binding","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues242
DetailsRegion: {"description":"Mediates interaction with SCN7A","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues22
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsActive site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05023","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues224
DetailsRegion: {"description":"immunoglobulin-like","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14094","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

PDB statisticsPDBj update infoContact PDBjnumon