7YZK

Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001653	molecular_function	peptide receptor activity
A	0004016	molecular_function	adenylate cyclase activity
A	0004383	molecular_function	guanylate cyclase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006171	biological_process	cAMP biosynthetic process
A	0006182	biological_process	cGMP biosynthetic process
A	0007168	biological_process	receptor guanylyl cyclase signaling pathway
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016849	molecular_function	phosphorus-oxygen lyase activity
A	0030145	molecular_function	manganese ion binding
A	0035556	biological_process	intracellular signal transduction
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0001653	molecular_function	peptide receptor activity
B	0004016	molecular_function	adenylate cyclase activity
B	0004383	molecular_function	guanylate cyclase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006171	biological_process	cAMP biosynthetic process
B	0006182	biological_process	cGMP biosynthetic process
B	0007168	biological_process	receptor guanylyl cyclase signaling pathway
B	0009190	biological_process	cyclic nucleotide biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016849	molecular_function	phosphorus-oxygen lyase activity
B	0030145	molecular_function	manganese ion binding
B	0035556	biological_process	intracellular signal transduction
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVV.GsrrffYdVWGDAVNvasrmE

Chain	Residue	Details
A	GLY355-GLU378

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	246
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	254
Details	Domain: {"description":"Guanylate cyclase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11447108","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---