7YXY

Cryo-EM structure of USP9X, local refinement of monomer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001764	biological_process	neuron migration
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005929	cellular_component	cilium
A	0005930	cellular_component	axoneme
A	0006307	biological_process	DNA alkylation repair
A	0007179	biological_process	transforming growth factor beta receptor signaling pathway
A	0007292	biological_process	female gamete generation
A	0008104	biological_process	intracellular protein localization
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016477	biological_process	cell migration
A	0016562	biological_process	protein import into peroxisome matrix, receptor recycling
A	0016567	biological_process	protein ubiquitination
A	0016579	biological_process	protein deubiquitination
A	0030426	cellular_component	growth cone
A	0030509	biological_process	BMP signaling pathway
A	0031647	biological_process	regulation of protein stability
A	0032092	biological_process	positive regulation of protein binding
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035520	biological_process	monoubiquitinated protein deubiquitination
A	0042752	biological_process	regulation of circadian rhythm
A	0048675	biological_process	axon extension
A	0050821	biological_process	protein stabilization
A	0060271	biological_process	cilium assembly
A	0061578	molecular_function	K63-linked deubiquitinase activity
A	0061824	biological_process	cytosolic ciliogenesis
A	0070410	molecular_function	co-SMAD binding
A	0070536	biological_process	protein K63-linked deubiquitination
A	0071947	biological_process	protein deubiquitination involved in ubiquitin-dependent protein catabolic process
A	0101005	molecular_function	deubiquitinase activity
A	0140313	molecular_function	molecular sequestering activity
A	0180017	molecular_function	K11-linked deubiquitinase activity
A	1904515	biological_process	positive regulation of TORC2 signaling
A	1990000	biological_process	amyloid fibril formation
A	1990380	molecular_function	K48-linked deubiquitinase activity

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknaGAtCYMNSvIQ

Chain	Residue	Details
A	GLY1558-GLN1573

---

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YrLvGVlvHsGqasg..GHY

Chain	Residue	Details
A	TYR1863-TYR1880

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30914461","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30914461","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WCH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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