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7YXX

Cryo-EM structure of USP9X

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001764biological_processneuron migration
A0004197molecular_functioncysteine-type endopeptidase activity
A0004843molecular_functioncysteine-type deubiquitinase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005929cellular_componentcilium
A0006307biological_processDNA alkylation repair
A0006508biological_processproteolysis
A0007059biological_processchromosome segregation
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007292biological_processfemale gamete generation
A0008104biological_processprotein localization
A0008234molecular_functioncysteine-type peptidase activity
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016562biological_processprotein import into peroxisome matrix, receptor recycling
A0016567biological_processprotein ubiquitination
A0016579biological_processprotein deubiquitination
A0030426cellular_componentgrowth cone
A0030509biological_processBMP signaling pathway
A0032092biological_processpositive regulation of protein binding
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035520biological_processmonoubiquitinated protein deubiquitination
A0042752biological_processregulation of circadian rhythm
A0042995cellular_componentcell projection
A0048511biological_processrhythmic process
A0048675biological_processaxon extension
A0050821biological_processprotein stabilization
A0051301biological_processcell division
A0060271biological_processcilium assembly
A0061578molecular_functionK63-linked deubiquitinase activity
A0061824biological_processcytosolic ciliogenesis
A0070410molecular_functionco-SMAD binding
A0070536biological_processprotein K63-linked deubiquitination
A0071947biological_processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
A0101005molecular_functiondeubiquitinase activity
A0140313molecular_functionmolecular sequestering activity
A0180017molecular_functionK11-linked deubiquitinase activity
A1904515biological_processpositive regulation of TORC2 signaling
A1990000biological_processamyloid fibril formation
A1990380molecular_functionK48-linked deubiquitinase activity
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001764biological_processneuron migration
B0004197molecular_functioncysteine-type endopeptidase activity
B0004843molecular_functioncysteine-type deubiquitinase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005929cellular_componentcilium
B0006307biological_processDNA alkylation repair
B0006508biological_processproteolysis
B0007059biological_processchromosome segregation
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007292biological_processfemale gamete generation
B0008104biological_processprotein localization
B0008234molecular_functioncysteine-type peptidase activity
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016562biological_processprotein import into peroxisome matrix, receptor recycling
B0016567biological_processprotein ubiquitination
B0016579biological_processprotein deubiquitination
B0030426cellular_componentgrowth cone
B0030509biological_processBMP signaling pathway
B0032092biological_processpositive regulation of protein binding
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035520biological_processmonoubiquitinated protein deubiquitination
B0042752biological_processregulation of circadian rhythm
B0042995cellular_componentcell projection
B0048511biological_processrhythmic process
B0048675biological_processaxon extension
B0050821biological_processprotein stabilization
B0051301biological_processcell division
B0060271biological_processcilium assembly
B0061578molecular_functionK63-linked deubiquitinase activity
B0061824biological_processcytosolic ciliogenesis
B0070410molecular_functionco-SMAD binding
B0070536biological_processprotein K63-linked deubiquitination
B0071947biological_processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
B0101005molecular_functiondeubiquitinase activity
B0140313molecular_functionmolecular sequestering activity
B0180017molecular_functionK11-linked deubiquitinase activity
B1904515biological_processpositive regulation of TORC2 signaling
B1990000biological_processamyloid fibril formation
B1990380molecular_functionK48-linked deubiquitinase activity
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001764biological_processneuron migration
C0004197molecular_functioncysteine-type endopeptidase activity
C0004843molecular_functioncysteine-type deubiquitinase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005929cellular_componentcilium
C0006307biological_processDNA alkylation repair
C0006508biological_processproteolysis
C0007059biological_processchromosome segregation
C0007179biological_processtransforming growth factor beta receptor signaling pathway
C0007292biological_processfemale gamete generation
C0008104biological_processprotein localization
C0008234molecular_functioncysteine-type peptidase activity
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016562biological_processprotein import into peroxisome matrix, receptor recycling
C0016567biological_processprotein ubiquitination
C0016579biological_processprotein deubiquitination
C0030426cellular_componentgrowth cone
C0030509biological_processBMP signaling pathway
C0032092biological_processpositive regulation of protein binding
C0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
C0035520biological_processmonoubiquitinated protein deubiquitination
C0042752biological_processregulation of circadian rhythm
C0042995cellular_componentcell projection
C0048511biological_processrhythmic process
C0048675biological_processaxon extension
C0050821biological_processprotein stabilization
C0051301biological_processcell division
C0060271biological_processcilium assembly
C0061578molecular_functionK63-linked deubiquitinase activity
C0061824biological_processcytosolic ciliogenesis
C0070410molecular_functionco-SMAD binding
C0070536biological_processprotein K63-linked deubiquitination
C0071947biological_processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
C0101005molecular_functiondeubiquitinase activity
C0140313molecular_functionmolecular sequestering activity
C0180017molecular_functionK11-linked deubiquitinase activity
C1904515biological_processpositive regulation of TORC2 signaling
C1990000biological_processamyloid fibril formation
C1990380molecular_functionK48-linked deubiquitinase activity
Functional Information from PROSITE/UniProt
site_idPS00972
Number of Residues16
DetailsUSP_1 Ubiquitin specific protease (USP) domain signature 1. GLknaGAtCYMNSvIQ
ChainResidueDetails
AGLY1558-GLN1573

site_idPS00973
Number of Residues18
DetailsUSP_2 Ubiquitin specific protease (USP) domain signature 2. YrLvGVlvHsGqasg..GHY
ChainResidueDetails
ATYR1863-TYR1880

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093, ECO:0000305|PubMed:30914461
ChainResidueDetails
ACYS1566
BCYS1566
CCYS1566

site_idSWS_FT_FI2
Number of Residues3
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093
ChainResidueDetails
AHIS1879
BHIS1879
CHIS1879

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:30914461, ECO:0007744|PDB:5WCH
ChainResidueDetails
ACYS1727
CHIS1729
CCYS1771
CCYS1774
AHIS1729
ACYS1771
ACYS1774
BCYS1727
BHIS1729
BCYS1771
BCYS1774
CCYS1727

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER588
BSER588
CSER588

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR590
BTHR590
CTHR590

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1600
BSER1600
CSER1600

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17693683, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2443
BSER2443
CSER2443

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR2540
BTYR2540
CTYR2540

site_idSWS_FT_FI9
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2547
BSER2547
CSER2547

site_idSWS_FT_FI10
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ATHR2551
BTHR2551
CTHR2551

223790

PDB entries from 2024-08-14

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