7YR2

SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008241	molecular_function	peptidyl-dipeptidase activity
A	0016020	cellular_component	membrane
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0055036	cellular_component	virion membrane
C	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0016020	cellular_component	membrane
D	0019031	cellular_component	viral envelope
D	0019064	biological_process	fusion of virus membrane with host plasma membrane
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0046813	biological_process	receptor-mediated virion attachment to host cell
D	0055036	cellular_component	virion membrane
D	0075509	biological_process	endocytosis involved in viral entry into host cell
E	0016020	cellular_component	membrane
E	0019031	cellular_component	viral envelope
E	0019064	biological_process	fusion of virus membrane with host plasma membrane
E	0039654	biological_process	fusion of virus membrane with host endosome membrane
E	0046813	biological_process	receptor-mediated virion attachment to host cell
E	0055036	cellular_component	virion membrane
E	0075509	biological_process	endocytosis involved in viral entry into host cell

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
A	THR371-GLN380

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3597
Details	TOPO_DOM: Extracellular => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
D	GLN17-ILE1216
E	GLN17-ILE1216
C	GLN17-ILE1216

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
D	TRP1217-MET1237
E	TRP1217-MET1237
C	TRP1217-MET1237

---

site_id	SWS_FT_FI3
Number of Residues	114
Details	TOPO_DOM: Cytoplasmic => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
A	ARG169
A	TRP477
A	LYS481

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
D	ALA688
E	ALA688
C	ALA688

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
D	ILE818
E	ILE818
C	ILE818

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	LIPID: S-palmitoyl cysteine; by host ZDHHC20 => ECO:0000269|PubMed:34599882

Chain	Residue	Details
D	THR1238
E	GLY1246
C	THR1238
C	SER1239
C	CYS1243
C	LEU1244
C	GLY1246
D	SER1239
D	CYS1243
D	LEU1244
D	GLY1246
E	THR1238
E	SER1239
E	CYS1243
E	LEU1244

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	LIPID: S-palmitoyl cysteine; by host ZDHHC20; partial => ECO:0000269|PubMed:34599882

Chain	Residue	Details
D	CYS1250
E	ASP1257
C	CYS1250
C	GLY1251
C	CYS1253
C	PHE1256
C	ASP1257
D	GLY1251
D	CYS1253
D	PHE1256
D	ASP1257
E	CYS1250
E	GLY1251
E	CYS1253
E	PHE1256

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN20
D	SER1161
D	VAL1176
E	ASN20
E	SER1161
E	VAL1176
C	ASN20
C	SER1161
C	VAL1176

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	TRP64
E	THR1077
C	TRP64
C	ASN125
C	ILE720
C	GLN804
C	THR1077
D	ASN125
D	ILE720
D	GLN804
D	THR1077
E	TRP64
E	ASN125
E	ILE720
E	GLN804

---

site_id	SWS_FT_FI10
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	LYS77
D	ARG152
D	LEU1197
E	LYS77
E	ARG152
E	LEU1197
C	LYS77
C	ARG152
C	LEU1197

---

site_id	SWS_FT_FI11
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	PHE168
E	ASN334
E	ARG346
E	GLU619
E	TYR660
E	HIS1101
C	PHE168
C	ILE285
C	ASN334
C	ARG346
C	GLU619
D	ILE285
C	TYR660
C	HIS1101
D	ASN334
D	ARG346
D	GLU619
D	TYR660
D	HIS1101
E	PHE168
E	ILE285

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ARG237
D	ILE712
E	ARG237
E	ILE712
C	ARG237
C	ILE712

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
D	ILE326
E	ILE326
C	ILE326

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
D	ARG328
E	ARG328
C	ARG328

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	ASN606
E	ASN606
C	ASN606

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
D	LYS679
D	HIS681
E	LYS679
E	HIS681
C	LYS679
C	HIS681

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
D	VAL1137
E	VAL1137
C	VAL1137

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