7YQH

Cryo-EM structure of 8-subunit Smc5/6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000725	biological_process	recombinational repair
A	0000781	cellular_component	chromosome, telomeric region
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0007059	biological_process	chromosome segregation
A	0016887	molecular_function	ATP hydrolysis activity
A	0016925	biological_process	protein sumoylation
A	0019789	molecular_function	SUMO transferase activity
A	0030915	cellular_component	Smc5-Smc6 complex
A	0032204	biological_process	regulation of telomere maintenance
A	0051304	biological_process	chromosome separation
A	0071139	biological_process	resolution of DNA recombination intermediates
A	0140588	biological_process	chromatin looping
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000781	cellular_component	chromosome, telomeric region
B	0003684	molecular_function	damaged DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005739	cellular_component	mitochondrion
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006310	biological_process	DNA recombination
B	0016887	molecular_function	ATP hydrolysis activity
B	0016925	biological_process	protein sumoylation
B	0019789	molecular_function	SUMO transferase activity
B	0030915	cellular_component	Smc5-Smc6 complex
B	0032204	biological_process	regulation of telomere maintenance
B	0035861	cellular_component	site of double-strand break
B	0051304	biological_process	chromosome separation
B	0071139	biological_process	resolution of DNA recombination intermediates
B	0140588	biological_process	chromatin looping
B	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000781	cellular_component	chromosome, telomeric region
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0008270	molecular_function	zinc ion binding
C	0016740	molecular_function	transferase activity
C	0016925	biological_process	protein sumoylation
C	0019789	molecular_function	SUMO transferase activity
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0030915	cellular_component	Smc5-Smc6 complex
C	0032204	biological_process	regulation of telomere maintenance
C	0046872	molecular_function	metal ion binding
C	0061665	molecular_function	SUMO ligase activity
C	0140588	biological_process	chromatin looping
C	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006310	biological_process	DNA recombination
D	0016925	biological_process	protein sumoylation
D	0019789	molecular_function	SUMO transferase activity
D	0030915	cellular_component	Smc5-Smc6 complex
D	0032204	biological_process	regulation of telomere maintenance
D	0042030	molecular_function	ATPase inhibitor activity
D	0140588	biological_process	chromatin looping
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000781	cellular_component	chromosome, telomeric region
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0016925	biological_process	protein sumoylation
E	0019789	molecular_function	SUMO transferase activity
E	0030915	cellular_component	Smc5-Smc6 complex
E	0032204	biological_process	regulation of telomere maintenance
E	0042030	molecular_function	ATPase inhibitor activity
E	0140588	biological_process	chromatin looping
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000781	cellular_component	chromosome, telomeric region
F	0004842	molecular_function	ubiquitin-protein transferase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006281	biological_process	DNA repair
F	0006301	biological_process	postreplication repair
F	0006310	biological_process	DNA recombination
F	0008270	molecular_function	zinc ion binding
F	0016740	molecular_function	transferase activity
F	0016925	biological_process	protein sumoylation
F	0019789	molecular_function	SUMO transferase activity
F	0030915	cellular_component	Smc5-Smc6 complex
F	0032204	biological_process	regulation of telomere maintenance
F	0046872	molecular_function	metal ion binding
F	0140588	biological_process	chromatin looping
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000781	cellular_component	chromosome, telomeric region
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0016925	biological_process	protein sumoylation
G	0019789	molecular_function	SUMO transferase activity
G	0030915	cellular_component	Smc5-Smc6 complex
G	0032204	biological_process	regulation of telomere maintenance
G	0140588	biological_process	chromatin looping
H	0000724	biological_process	double-strand break repair via homologous recombination
H	0000781	cellular_component	chromosome, telomeric region
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0006281	biological_process	DNA repair
H	0006310	biological_process	DNA recombination
H	0016925	biological_process	protein sumoylation
H	0019789	molecular_function	SUMO transferase activity
H	0030915	cellular_component	Smc5-Smc6 complex
H	0032204	biological_process	regulation of telomere maintenance
H	0032991	cellular_component	protein-containing complex
H	0043232	cellular_component	intracellular non-membrane-bounded organelle
H	0140588	biological_process	chromatin looping

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	59
Details	ZN_FING: RING-type; atypical => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
F	LEU268-SER327

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
D	SER101
C	HIS202
C	CYS221
C	CYS226

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