Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7YOB

Crystal structure of Aldehyde dehydrogenase 1A1 from mouse

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0001758	molecular_function	retinal dehydrogenase activity
A	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
A	0002138	biological_process	retinoic acid biosynthetic process
A	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006001	biological_process	fructose catabolic process
A	0006629	biological_process	lipid metabolic process
A	0006915	biological_process	apoptotic process
A	0006979	biological_process	response to oxidative stress
A	0009410	biological_process	response to xenobiotic stimulus
A	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
A	0030392	biological_process	fructosamine catabolic process
A	0030424	cellular_component	axon
A	0036438	biological_process	maintenance of lens transparency
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0042802	molecular_function	identical protein binding
A	0042904	biological_process	9-cis-retinoic acid biosynthetic process
A	0042905	biological_process	9-cis-retinoic acid metabolic process
A	0042995	cellular_component	cell projection
A	0043065	biological_process	positive regulation of apoptotic process
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0045202	cellular_component	synapse
A	0045471	biological_process	response to ethanol
A	0048048	biological_process	embryonic eye morphogenesis
A	0051287	molecular_function	NAD binding
A	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
A	0110095	biological_process	cellular detoxification of aldehyde
A	0120163	biological_process	negative regulation of cold-induced thermogenesis
B	0001523	biological_process	retinoid metabolic process
B	0001758	molecular_function	retinal dehydrogenase activity
B	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
B	0002138	biological_process	retinoic acid biosynthetic process
B	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006001	biological_process	fructose catabolic process
B	0006629	biological_process	lipid metabolic process
B	0006915	biological_process	apoptotic process
B	0006979	biological_process	response to oxidative stress
B	0009410	biological_process	response to xenobiotic stimulus
B	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
B	0030392	biological_process	fructosamine catabolic process
B	0030424	cellular_component	axon
B	0036438	biological_process	maintenance of lens transparency
B	0042572	biological_process	retinol metabolic process
B	0042573	biological_process	retinoic acid metabolic process
B	0042802	molecular_function	identical protein binding
B	0042904	biological_process	9-cis-retinoic acid biosynthetic process
B	0042905	biological_process	9-cis-retinoic acid metabolic process
B	0042995	cellular_component	cell projection
B	0043065	biological_process	positive regulation of apoptotic process
B	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
B	0045202	cellular_component	synapse
B	0045471	biological_process	response to ethanol
B	0048048	biological_process	embryonic eye morphogenesis
B	0051287	molecular_function	NAD binding
B	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
B	0110095	biological_process	cellular detoxification of aldehyde
B	0120163	biological_process	negative regulation of cold-induced thermogenesis
C	0001523	biological_process	retinoid metabolic process
C	0001758	molecular_function	retinal dehydrogenase activity
C	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
C	0002138	biological_process	retinoic acid biosynthetic process
C	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006001	biological_process	fructose catabolic process
C	0006629	biological_process	lipid metabolic process
C	0006915	biological_process	apoptotic process
C	0006979	biological_process	response to oxidative stress
C	0009410	biological_process	response to xenobiotic stimulus
C	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
C	0030392	biological_process	fructosamine catabolic process
C	0030424	cellular_component	axon
C	0036438	biological_process	maintenance of lens transparency
C	0042572	biological_process	retinol metabolic process
C	0042573	biological_process	retinoic acid metabolic process
C	0042802	molecular_function	identical protein binding
C	0042904	biological_process	9-cis-retinoic acid biosynthetic process
C	0042905	biological_process	9-cis-retinoic acid metabolic process
C	0042995	cellular_component	cell projection
C	0043065	biological_process	positive regulation of apoptotic process
C	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
C	0045202	cellular_component	synapse
C	0045471	biological_process	response to ethanol
C	0048048	biological_process	embryonic eye morphogenesis
C	0051287	molecular_function	NAD binding
C	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
C	0110095	biological_process	cellular detoxification of aldehyde
C	0120163	biological_process	negative regulation of cold-induced thermogenesis
D	0001523	biological_process	retinoid metabolic process
D	0001758	molecular_function	retinal dehydrogenase activity
D	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
D	0002138	biological_process	retinoic acid biosynthetic process
D	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006001	biological_process	fructose catabolic process
D	0006629	biological_process	lipid metabolic process
D	0006915	biological_process	apoptotic process
D	0006979	biological_process	response to oxidative stress
D	0009410	biological_process	response to xenobiotic stimulus
D	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
D	0030392	biological_process	fructosamine catabolic process
D	0030424	cellular_component	axon
D	0036438	biological_process	maintenance of lens transparency
D	0042572	biological_process	retinol metabolic process
D	0042573	biological_process	retinoic acid metabolic process
D	0042802	molecular_function	identical protein binding
D	0042904	biological_process	9-cis-retinoic acid biosynthetic process
D	0042905	biological_process	9-cis-retinoic acid metabolic process
D	0042995	cellular_component	cell projection
D	0043065	biological_process	positive regulation of apoptotic process
D	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
D	0045202	cellular_component	synapse
D	0045471	biological_process	response to ethanol
D	0048048	biological_process	embryonic eye morphogenesis
D	0051287	molecular_function	NAD binding
D	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
D	0110095	biological_process	cellular detoxification of aldehyde
D	0120163	biological_process	negative regulation of cold-induced thermogenesis
E	0001523	biological_process	retinoid metabolic process
E	0001758	molecular_function	retinal dehydrogenase activity
E	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
E	0002138	biological_process	retinoic acid biosynthetic process
E	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006001	biological_process	fructose catabolic process
E	0006629	biological_process	lipid metabolic process
E	0006915	biological_process	apoptotic process
E	0006979	biological_process	response to oxidative stress
E	0009410	biological_process	response to xenobiotic stimulus
E	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
E	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
E	0030392	biological_process	fructosamine catabolic process
E	0030424	cellular_component	axon
E	0036438	biological_process	maintenance of lens transparency
E	0042572	biological_process	retinol metabolic process
E	0042573	biological_process	retinoic acid metabolic process
E	0042802	molecular_function	identical protein binding
E	0042904	biological_process	9-cis-retinoic acid biosynthetic process
E	0042905	biological_process	9-cis-retinoic acid metabolic process
E	0042995	cellular_component	cell projection
E	0043065	biological_process	positive regulation of apoptotic process
E	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
E	0045202	cellular_component	synapse
E	0045471	biological_process	response to ethanol
E	0048048	biological_process	embryonic eye morphogenesis
E	0051287	molecular_function	NAD binding
E	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
E	0110095	biological_process	cellular detoxification of aldehyde
E	0120163	biological_process	negative regulation of cold-induced thermogenesis
F	0001523	biological_process	retinoid metabolic process
F	0001758	molecular_function	retinal dehydrogenase activity
F	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
F	0002138	biological_process	retinoic acid biosynthetic process
F	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006001	biological_process	fructose catabolic process
F	0006629	biological_process	lipid metabolic process
F	0006915	biological_process	apoptotic process
F	0006979	biological_process	response to oxidative stress
F	0009410	biological_process	response to xenobiotic stimulus
F	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
F	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
F	0030392	biological_process	fructosamine catabolic process
F	0030424	cellular_component	axon
F	0036438	biological_process	maintenance of lens transparency
F	0042572	biological_process	retinol metabolic process
F	0042573	biological_process	retinoic acid metabolic process
F	0042802	molecular_function	identical protein binding
F	0042904	biological_process	9-cis-retinoic acid biosynthetic process
F	0042905	biological_process	9-cis-retinoic acid metabolic process
F	0042995	cellular_component	cell projection
F	0043065	biological_process	positive regulation of apoptotic process
F	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
F	0045202	cellular_component	synapse
F	0045471	biological_process	response to ethanol
F	0048048	biological_process	embryonic eye morphogenesis
F	0051287	molecular_function	NAD binding
F	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
F	0110095	biological_process	cellular detoxification of aldehyde
F	0120163	biological_process	negative regulation of cold-induced thermogenesis
G	0001523	biological_process	retinoid metabolic process
G	0001758	molecular_function	retinal dehydrogenase activity
G	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
G	0002138	biological_process	retinoic acid biosynthetic process
G	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006001	biological_process	fructose catabolic process
G	0006629	biological_process	lipid metabolic process
G	0006915	biological_process	apoptotic process
G	0006979	biological_process	response to oxidative stress
G	0009410	biological_process	response to xenobiotic stimulus
G	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
G	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
G	0030392	biological_process	fructosamine catabolic process
G	0030424	cellular_component	axon
G	0036438	biological_process	maintenance of lens transparency
G	0042572	biological_process	retinol metabolic process
G	0042573	biological_process	retinoic acid metabolic process
G	0042802	molecular_function	identical protein binding
G	0042904	biological_process	9-cis-retinoic acid biosynthetic process
G	0042905	biological_process	9-cis-retinoic acid metabolic process
G	0042995	cellular_component	cell projection
G	0043065	biological_process	positive regulation of apoptotic process
G	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
G	0045202	cellular_component	synapse
G	0045471	biological_process	response to ethanol
G	0048048	biological_process	embryonic eye morphogenesis
G	0051287	molecular_function	NAD binding
G	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
G	0110095	biological_process	cellular detoxification of aldehyde
G	0120163	biological_process	negative regulation of cold-induced thermogenesis
H	0001523	biological_process	retinoid metabolic process
H	0001758	molecular_function	retinal dehydrogenase activity
H	0002072	biological_process	optic cup morphogenesis involved in camera-type eye development
H	0002138	biological_process	retinoic acid biosynthetic process
H	0004028	molecular_function	3-chloroallyl aldehyde dehydrogenase activity
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006001	biological_process	fructose catabolic process
H	0006629	biological_process	lipid metabolic process
H	0006915	biological_process	apoptotic process
H	0006979	biological_process	response to oxidative stress
H	0009410	biological_process	response to xenobiotic stimulus
H	0009449	biological_process	gamma-aminobutyric acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0018479	molecular_function	benzaldehyde dehydrogenase (NAD+) activity
H	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
H	0030392	biological_process	fructosamine catabolic process
H	0030424	cellular_component	axon
H	0036438	biological_process	maintenance of lens transparency
H	0042572	biological_process	retinol metabolic process
H	0042573	biological_process	retinoic acid metabolic process
H	0042802	molecular_function	identical protein binding
H	0042904	biological_process	9-cis-retinoic acid biosynthetic process
H	0042905	biological_process	9-cis-retinoic acid metabolic process
H	0042995	cellular_component	cell projection
H	0043065	biological_process	positive regulation of apoptotic process
H	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
H	0045202	cellular_component	synapse
H	0045471	biological_process	response to ethanol
H	0048048	biological_process	embryonic eye morphogenesis
H	0051287	molecular_function	NAD binding
H	0106373	molecular_function	3-deoxyglucosone dehydrogenase activity
H	0110095	biological_process	cellular detoxification of aldehyde
H	0120163	biological_process	negative regulation of cold-induced thermogenesis

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCVAAS

Chain	Residue	Details
A	PHE296-SER307

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU268-PRO275

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	GLU269
B	GLU269
C	GLU269
D	GLU269
E	GLU269
G	GLU269
H	GLU269
F	GLU269

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	CYS303
B	CYS303
C	CYS303
D	CYS303
E	CYS303
G	CYS303
H	CYS303
F	CYS303

site_id	SWS_FT_FI3
Number of Residues	56
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00352

Chain	Residue	Details
A	ILE167
B	GLY226
B	GLY246
B	GLU269
B	GLU349
B	GLU400
C	ILE167
C	LYS193
C	GLY226
C	GLY246
C	GLU269
A	LYS193
C	GLU349
C	GLU400
D	ILE167
D	LYS193
D	GLY226
D	GLY246
D	GLU269
D	GLU349
D	GLU400
E	ILE167
A	GLY226
E	LYS193
E	GLY226
E	GLY246
E	GLU269
E	GLU349
E	GLU400
G	ILE167
G	LYS193
G	GLY226
G	GLY246
A	GLY246
G	GLU269
G	GLU349
G	GLU400
H	ILE167
H	LYS193
H	GLY226
H	GLY246
H	GLU269
H	GLU349
H	GLU400
A	GLU269
F	ILE167
F	LYS193
F	GLY226
F	GLY246
F	GLU269
F	GLU349
F	GLU400
A	GLU349
A	GLU400
B	ILE167
B	LYS193

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000250\|UniProtKB:P20000

Chain	Residue	Details
A	ASN170
B	ASN170
C	ASN170
D	ASN170
E	ASN170
G	ASN170
H	ASN170
F	ASN170

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N-acetylserine => ECO:0000250\|UniProtKB:P15437

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2
E	SER2
G	SER2
H	SER2
F	SER2

site_id	SWS_FT_FI6
Number of Residues	72
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P00352

Chain	Residue	Details
A	LYS91
B	LYS91
B	LYS128
B	LYS252
B	LYS353
B	LYS367
B	LYS410
B	LYS419
B	LYS435
B	LYS495
C	LYS91
A	LYS128
C	LYS128
C	LYS252
C	LYS353
C	LYS367
C	LYS410
C	LYS419
C	LYS435
C	LYS495
D	LYS91
D	LYS128
A	LYS252
D	LYS252
D	LYS353
D	LYS367
D	LYS410
D	LYS419
D	LYS435
D	LYS495
E	LYS91
E	LYS128
E	LYS252
A	LYS353
E	LYS353
E	LYS367
E	LYS410
E	LYS419
E	LYS435
E	LYS495
G	LYS91
G	LYS128
G	LYS252
G	LYS353
A	LYS367
G	LYS367
G	LYS410
G	LYS419
G	LYS435
G	LYS495
H	LYS91
H	LYS128
H	LYS252
H	LYS353
H	LYS367
A	LYS410
H	LYS410
H	LYS419
H	LYS435
H	LYS495
F	LYS91
F	LYS128
F	LYS252
F	LYS353
F	LYS367
F	LYS410
A	LYS419
F	LYS419
F	LYS435
F	LYS495
A	LYS435
A	LYS495

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P00352

Chain	Residue	Details
A	THR337
B	THR337
C	THR337
D	THR337
E	THR337
G	THR337
H	THR337
F	THR337

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P00352

Chain	Residue	Details
A	SER413
B	SER413
C	SER413
D	SER413
E	SER413
G	SER413
H	SER413
F	SER413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)