7YO5

Cryo-EM structure of RCK1 mutated human Slo1 apo

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VITNPPY

Chain	Residue	Details
A	VAL1033-TYR1039

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S0 => ECO:0000255

Chain	Residue	Details
A	TRP22-LEU42
B	TRP22-LEU42
C	TRP22-LEU42
D	TRP22-LEU42

---

site_id	SWS_FT_FI2
Number of Residues	348
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP43-ARG113
D	TRP43-ARG113
D	ALA171-LYS174
D	LEU221-LEU235
A	ALA171-LYS174
A	LEU221-LEU235
B	TRP43-ARG113
B	ALA171-LYS174
B	LEU221-LEU235
C	TRP43-ARG113
C	ALA171-LYS174
C	LEU221-LEU235

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000255

Chain	Residue	Details
A	VAL114-SER134
B	VAL114-SER134
C	VAL114-SER134
D	VAL114-SER134

---

site_id	SWS_FT_FI4
Number of Residues	152
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER135-THR149
C	SER196-LEU199
C	GLU257-GLN270
C	TYR294-LEU302
D	SER135-THR149
D	SER196-LEU199
D	GLU257-GLN270
D	TYR294-LEU302
A	SER196-LEU199
A	GLU257-GLN270
A	TYR294-LEU302
B	SER135-THR149
B	SER196-LEU199
B	GLU257-GLN270
B	TYR294-LEU302
C	SER135-THR149

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000255

Chain	Residue	Details
A	LEU150-ALA170
B	LEU150-ALA170
C	LEU150-ALA170
D	LEU150-ALA170

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000255

Chain	Residue	Details
A	LEU175-VAL195
B	LEU175-VAL195
C	LEU175-VAL195
D	LEU175-VAL195

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S4 => ECO:0000255

Chain	Residue	Details
A	ASN200-ILE220
B	ASN200-ILE220
C	ASN200-ILE220
D	ASN200-ILE220

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000255

Chain	Residue	Details
A	VAL236-VAL256
B	VAL236-VAL256
C	VAL236-VAL256
D	VAL236-VAL256

---

site_id	SWS_FT_FI9
Number of Residues	88
Details	INTRAMEM: Pore-forming; Name=P region => ECO:0000255

Chain	Residue	Details
A	ALA271-VAL293
B	ALA271-VAL293
C	ALA271-VAL293
D	ALA271-VAL293

---

site_id	SWS_FT_FI10
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000255

Chain	Residue	Details
A	PHE303-ILE323
B	PHE303-ILE323
C	PHE303-ILE323
D	PHE303-ILE323

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	GLU374
D	GLU374
D	GLN397
D	GLU399
A	GLN397
A	GLU399
B	GLU374
B	GLN397
B	GLU399
C	GLU374
C	GLN397
C	GLU399

---

site_id	SWS_FT_FI12
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:B7ZC96

Chain	Residue	Details
A	PRO947
C	GLU950
C	ILE953
C	GLU955
D	PRO947
D	GLU950
D	ILE953
D	GLU955
A	GLU950
A	ILE953
A	GLU955
B	PRO947
B	GLU950
B	ILE953
B	GLU955
C	PRO947

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q08460

Chain	Residue	Details
A	LYS698
A	LEU905
B	LYS698
B	LEU905
C	LYS698
C	LEU905
D	LYS698
D	LEU905

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q08460

Chain	Residue	Details
A	ILE700
B	VAL917
C	ILE700
C	THR713
C	GLY717
C	THR913
C	VAL917
D	ILE700
D	THR713
D	GLY717
D	THR913
A	THR713
D	VAL917
A	GLY717
A	THR913
A	VAL917
B	ILE700
B	THR713
B	GLY717
B	THR913

---

site_id	SWS_FT_FI15
Number of Residues	12
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288

Chain	Residue	Details
A	CYS53
D	CYS53
D	CYS54
D	CYS56
A	CYS54
A	CYS56
B	CYS53
B	CYS54
B	CYS56
C	CYS53
C	CYS54
C	CYS56

---