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7YIF

Human KCNH5 pre-open state 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005516molecular_functioncalmodulin binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009986cellular_componentcell surface
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0016020cellular_componentmembrane
A0034702cellular_componentmonoatomic ion channel complex
A0042391biological_processregulation of membrane potential
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
B0005216molecular_functionmonoatomic ion channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005516molecular_functioncalmodulin binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0009986cellular_componentcell surface
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0034702cellular_componentmonoatomic ion channel complex
B0042391biological_processregulation of membrane potential
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
C0005216molecular_functionmonoatomic ion channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005516molecular_functioncalmodulin binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009986cellular_componentcell surface
C0010389biological_processregulation of G2/M transition of mitotic cell cycle
C0016020cellular_componentmembrane
C0034702cellular_componentmonoatomic ion channel complex
C0042391biological_processregulation of membrane potential
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
D0005216molecular_functionmonoatomic ion channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005516molecular_functioncalmodulin binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0009986cellular_componentcell surface
D0010389biological_processregulation of G2/M transition of mitotic cell cycle
D0016020cellular_componentmembrane
D0034702cellular_componentmonoatomic ion channel complex
D0042391biological_processregulation of membrane potential
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3068
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-TRP217
CASN265-THR291
CTYR341-ALA346
CTHR468-PHE988
DMET1-TRP217
DASN265-THR291
DTYR341-ALA346
DTHR468-PHE988
AASN265-THR291
ATYR341-ALA346
ATHR468-PHE988
BMET1-TRP217
BASN265-THR291
BTYR341-ALA346
BTHR468-PHE988
CMET1-TRP217

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AASP218-PHE238
BASP218-PHE238
CASP218-PHE238
DASP218-PHE238

site_idSWS_FT_FI3
Number of Residues264
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ALYS239-ASN243
CASP313-LEU319
CTYR368-TYR419
CTHR441-LYS446
DLYS239-ASN243
DASP313-LEU319
DTYR368-TYR419
DTHR441-LYS446
AASP313-LEU319
ATYR368-TYR419
ATHR441-LYS446
BLYS239-ASN243
BASP313-LEU319
BTYR368-TYR419
BTHR441-LYS446
CLYS239-ASN243

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
AASN244-LEU264
BASN244-LEU264
CASN244-LEU264
DASN244-LEU264

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
ATRP292-VAL312
BTRP292-VAL312
CTRP292-VAL312
DTRP292-VAL312

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
APHE320-HIS340
BPHE320-HIS340
CPHE320-HIS340
DPHE320-HIS340

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
AALA347-TRP367
BALA347-TRP367
CALA347-TRP367
DALA347-TRP367

site_idSWS_FT_FI8
Number of Residues80
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
AVAL420-PRO440
BVAL420-PRO440
CVAL420-PRO440
DVAL420-PRO440

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AMET447-VAL467
BMET447-VAL467
CMET447-VAL467
DMET447-VAL467

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AALA550
BALA550
CALA550
DALA550

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q920E3
ChainResidueDetails
ASER883
BSER883
CSER883
DSER883

site_idSWS_FT_FI12
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN403
BASN403
CASN403
DASN403

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18655026
ChainResidueDetails
ALYS785
BLYS785
CLYS785
DLYS785

227111

PDB entries from 2024-11-06

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