Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7YBU

Human propionyl-coenzyme A carboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006631	biological_process	fatty acid metabolic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009374	molecular_function	biotin binding
A	0016042	biological_process	lipid catabolic process
A	0016874	molecular_function	ligase activity
A	0019626	biological_process	short-chain fatty acid catabolic process
A	0019899	molecular_function	enzyme binding
A	0046872	molecular_function	metal ion binding
A	1902494	cellular_component	catalytic complex
B	0004658	molecular_function	propionyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006631	biological_process	fatty acid metabolic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009374	molecular_function	biotin binding
B	0016042	biological_process	lipid catabolic process
B	0016874	molecular_function	ligase activity
B	0019626	biological_process	short-chain fatty acid catabolic process
B	0019899	molecular_function	enzyme binding
B	0046872	molecular_function	metal ion binding
B	1902494	cellular_component	catalytic complex
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006631	biological_process	fatty acid metabolic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0016874	molecular_function	ligase activity
C	0019626	biological_process	short-chain fatty acid catabolic process
C	1902494	cellular_component	catalytic complex
D	0004658	molecular_function	propionyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006631	biological_process	fatty acid metabolic process
D	0009081	biological_process	branched-chain amino acid metabolic process
D	0009374	molecular_function	biotin binding
D	0016042	biological_process	lipid catabolic process
D	0016874	molecular_function	ligase activity
D	0019626	biological_process	short-chain fatty acid catabolic process
D	0019899	molecular_function	enzyme binding
D	0046872	molecular_function	metal ion binding
D	1902494	cellular_component	catalytic complex
E	0004658	molecular_function	propionyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006631	biological_process	fatty acid metabolic process
E	0009081	biological_process	branched-chain amino acid metabolic process
E	0016874	molecular_function	ligase activity
E	0019626	biological_process	short-chain fatty acid catabolic process
E	1902494	cellular_component	catalytic complex
F	0004658	molecular_function	propionyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006631	biological_process	fatty acid metabolic process
F	0009081	biological_process	branched-chain amino acid metabolic process
F	0009374	molecular_function	biotin binding
F	0016042	biological_process	lipid catabolic process
F	0016874	molecular_function	ligase activity
F	0019626	biological_process	short-chain fatty acid catabolic process
F	0019899	molecular_function	enzyme binding
F	0046872	molecular_function	metal ion binding
F	1902494	cellular_component	catalytic complex
G	0004658	molecular_function	propionyl-CoA carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006631	biological_process	fatty acid metabolic process
G	0009081	biological_process	branched-chain amino acid metabolic process
G	0016874	molecular_function	ligase activity
G	0019626	biological_process	short-chain fatty acid catabolic process
G	1902494	cellular_component	catalytic complex
H	0004658	molecular_function	propionyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006631	biological_process	fatty acid metabolic process
H	0009081	biological_process	branched-chain amino acid metabolic process
H	0009374	molecular_function	biotin binding
H	0016042	biological_process	lipid catabolic process
H	0016874	molecular_function	ligase activity
H	0019626	biological_process	short-chain fatty acid catabolic process
H	0019899	molecular_function	enzyme binding
H	0046872	molecular_function	metal ion binding
H	1902494	cellular_component	catalytic complex
I	0004658	molecular_function	propionyl-CoA carboxylase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005829	cellular_component	cytosol
I	0006631	biological_process	fatty acid metabolic process
I	0009081	biological_process	branched-chain amino acid metabolic process
I	0016874	molecular_function	ligase activity
I	0019626	biological_process	short-chain fatty acid catabolic process
I	1902494	cellular_component	catalytic complex
J	0004658	molecular_function	propionyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005829	cellular_component	cytosol
J	0006631	biological_process	fatty acid metabolic process
J	0009081	biological_process	branched-chain amino acid metabolic process
J	0009374	molecular_function	biotin binding
J	0016042	biological_process	lipid catabolic process
J	0016874	molecular_function	ligase activity
J	0019626	biological_process	short-chain fatty acid catabolic process
J	0019899	molecular_function	enzyme binding
J	0046872	molecular_function	metal ion binding
J	1902494	cellular_component	catalytic complex
K	0004658	molecular_function	propionyl-CoA carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006631	biological_process	fatty acid metabolic process
K	0009081	biological_process	branched-chain amino acid metabolic process
K	0016874	molecular_function	ligase activity
K	0019626	biological_process	short-chain fatty acid catabolic process
K	1902494	cellular_component	catalytic complex
P	0004658	molecular_function	propionyl-CoA carboxylase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0005829	cellular_component	cytosol
P	0006631	biological_process	fatty acid metabolic process
P	0009081	biological_process	branched-chain amino acid metabolic process
P	0016874	molecular_function	ligase activity
P	0019626	biological_process	short-chain fatty acid catabolic process
P	1902494	cellular_component	catalytic complex

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQeIcvIeAMKMqnsMtA

Chain	Residue	Details
A	GLY684-ALA701

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASaggGGkG

Chain	Residue	Details
A	TYR214-GLY228

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLEMNTRL

Chain	Residue	Details
A	PHE347-LEU354

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
C	SER71
E	SER71
G	SER71
I	SER71
K	SER71
P	SER71

site_id	SWS_FT_FI2
Number of Residues	18
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q99MN9

Chain	Residue	Details
C	LYS99
I	LYS99
I	LYS474
I	LYS489
K	LYS99
K	LYS474
K	LYS489
P	LYS99
P	LYS474
P	LYS489
C	LYS474
C	LYS489
E	LYS99
E	LYS474
E	LYS489
G	LYS99
G	LYS474
G	LYS489

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q99MN9

Chain	Residue	Details
C	LYS248
D	GLU336
D	GLU349
D	ASN351
F	ALA209
F	GLU336
F	GLU349
F	ASN351
H	ALA209
H	GLU336
H	GLU349
E	LYS248
H	ASN351
J	ALA209
J	GLU336
J	GLU349
J	ASN351
G	LYS248
I	LYS248
K	LYS248
P	LYS248
B	GLU349
B	ASN351
D	ALA209

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q5LUF3

Chain	Residue	Details
A	PHE409
B	PHE409
D	PHE409
F	PHE409
H	PHE409
J	PHE409

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q91ZA3

Chain	Residue	Details
A	LYS65
D	LYS150
D	LYS200
D	LYS328
F	LYS65
F	LYS150
F	LYS200
F	LYS328
H	LYS65
H	LYS150
H	LYS200
A	LYS150
H	LYS328
J	LYS65
J	LYS150
J	LYS200
J	LYS328
A	LYS200
A	LYS328
B	LYS65
B	LYS150
B	LYS200
B	LYS328
D	LYS65

site_id	SWS_FT_FI6
Number of Residues	42
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q91ZA3

Chain	Residue	Details
A	LYS119
B	LYS385
B	LYS407
B	LYS502
B	LYS513
B	LYS648
D	LYS119
D	LYS262
D	LYS385
D	LYS407
D	LYS502
A	LYS262
D	LYS513
D	LYS648
F	LYS119
F	LYS262
F	LYS385
F	LYS407
F	LYS502
F	LYS513
F	LYS648
H	LYS119
A	LYS385
H	LYS262
H	LYS385
H	LYS407
H	LYS502
H	LYS513
H	LYS648
J	LYS119
J	LYS262
J	LYS385
J	LYS407
A	LYS407
J	LYS502
J	LYS513
J	LYS648
A	LYS502
A	LYS513
A	LYS648
B	LYS119
B	LYS262

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q91ZA3

Chain	Residue	Details
A	SER252
B	SER252
D	SER252
F	SER252
H	SER252
J	SER252

site_id	SWS_FT_FI8
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q91ZA3

Chain	Residue	Details
A	LYS496
B	LYS496
D	LYS496
F	LYS496
H	LYS496
J	LYS496

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: N6-biotinyllysine; by HLCS => ECO:0000255\|PROSITE-ProRule:PRU01066, ECO:0000269\|PubMed:20443544

Chain	Residue	Details
A	LYS694
B	LYS694
D	LYS694
F	LYS694
H	LYS694
J	LYS694

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)