7YAJ
CryoEM structure of SPCA1a in E1-Mn-AMPPCP state subclass 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005388 | molecular_function | P-type calcium transporter activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005802 | cellular_component | trans-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006828 | biological_process | manganese ion transport |
| A | 0006874 | biological_process | intracellular calcium ion homeostasis |
| A | 0008544 | biological_process | epidermis development |
| A | 0016020 | cellular_component | membrane |
| A | 0016339 | biological_process | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0032468 | biological_process | Golgi calcium ion homeostasis |
| A | 0032472 | biological_process | Golgi calcium ion transport |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0033106 | cellular_component | cis-Golgi network membrane |
| A | 0042998 | biological_process | positive regulation of Golgi to plasma membrane protein transport |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071421 | biological_process | manganese ion transmembrane transport |
| A | 0098629 | biological_process | trans-Golgi network membrane organization |
| A | 0140613 | molecular_function | P-type manganese transporter activity |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP350-THR356 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 646 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-PRO70 | |
| A | SER124-MET262 | |
| A | VAL313-ILE699 | |
| A | VAL751-ILE770 | |
| A | GLN829-ASN841 | |
| A | LYS897-VAL919 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU71-ALA91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Lumenal => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL92-VAL104 | |
| A | VAL283-MET294 | |
| A | ALA720-LEU729 | |
| A | PHE794-THR808 | |
| A | PHE861-ILE875 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| A | SER105-ARG123 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP263-LEU282 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE295-ILE312 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS700-LEU719 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN730-GLY750 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU771-VAL793 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000250 |
| Chain | Residue | Details |
| A | THR809-SER828 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG842-TYR860 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU876-LYS896 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP350 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL303 | |
| A | ALA304 | |
| A | ILE306 | |
| A | GLU308 | |
| A | ASP644 | |
| A | ASP648 | |
| A | ASN738 | |
| A | ASP742 |
