7Y8Q
Amyloid-beta assemblage on GM1-containing membranes
Functional Information from GO Data
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
A | HIS6 | |
E | HIS14 | |
F | HIS6 | |
F | HIS14 | |
G | HIS6 | |
G | HIS14 | |
H | HIS6 | |
H | HIS14 | |
A | HIS14 | |
B | HIS6 | |
B | HIS14 | |
C | HIS6 | |
C | HIS14 | |
D | HIS6 | |
D | HIS14 | |
E | HIS6 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
Chain | Residue | Details |
A | TYR10 | |
B | TYR10 | |
C | TYR10 | |
D | TYR10 | |
E | TYR10 | |
F | TYR10 | |
G | TYR10 | |
H | TYR10 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
A | HIS13 | |
B | HIS13 | |
C | HIS13 | |
D | HIS13 | |
E | HIS13 | |
F | HIS13 | |
G | HIS13 | |
H | HIS13 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
Chain | Residue | Details |
A | ASP1 | |
B | ASP1 | |
C | ASP1 | |
D | ASP1 | |
E | ASP1 | |
F | ASP1 | |
G | ASP1 | |
H | ASP1 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
Chain | Residue | Details |
A | ASP7 | |
B | ASP7 | |
C | ASP7 | |
D | ASP7 | |
E | ASP7 | |
F | ASP7 | |
G | ASP7 | |
H | ASP7 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
A | LYS16 | |
B | LYS16 | |
C | LYS16 | |
D | LYS16 | |
E | LYS16 | |
F | LYS16 | |
G | LYS16 | |
H | LYS16 |
site_id | SWS_FT_FI7 |
Number of Residues | 8 |
Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
Chain | Residue | Details |
A | PHE19 | |
B | PHE19 | |
C | PHE19 | |
D | PHE19 | |
E | PHE19 | |
F | PHE19 | |
G | PHE19 | |
H | PHE19 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | SITE: Implicated in free radical propagation => ECO:0000250 |
Chain | Residue | Details |
A | GLY33 | |
B | GLY33 | |
C | GLY33 | |
D | GLY33 | |
E | GLY33 | |
F | GLY33 | |
G | GLY33 | |
H | GLY33 |
site_id | SWS_FT_FI9 |
Number of Residues | 8 |
Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
Chain | Residue | Details |
A | MET35 | |
B | MET35 | |
C | MET35 | |
D | MET35 | |
E | MET35 | |
F | MET35 | |
G | MET35 | |
H | MET35 |
site_id | SWS_FT_FI10 |
Number of Residues | 8 |
Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
A | VAL40 | |
B | VAL40 | |
C | VAL40 | |
D | VAL40 | |
E | VAL40 | |
F | VAL40 | |
G | VAL40 | |
H | VAL40 |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
Chain | Residue | Details |
A | TYR10 | |
B | TYR10 | |
C | TYR10 | |
D | TYR10 | |
E | TYR10 | |
F | TYR10 | |
G | TYR10 | |
H | TYR10 |