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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7Y75

SIT1-ACE2-BA.2 RBD

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001618molecular_functionvirus receptor activity
A0001817biological_processregulation of cytokine production
A0002003biological_processangiotensin maturation
A0003051biological_processangiotensin-mediated drinking behavior
A0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
A0004175molecular_functionendopeptidase activity
A0004180molecular_functioncarboxypeptidase activity
A0004181molecular_functionmetallocarboxypeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008241molecular_functionpeptidyl-dipeptidase activity
A0008270molecular_functionzinc ion binding
A0009986cellular_componentcell surface
A0015827biological_processtryptophan transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0019058biological_processviral life cycle
A0019065biological_processreceptor-mediated endocytosis of virus by host cell
A0019229biological_processregulation of vasoconstriction
A0030666cellular_componentendocytic vesicle membrane
A0031526cellular_componentbrush border membrane
A0042127biological_processregulation of cell population proliferation
A0042802molecular_functionidentical protein binding
A0045121cellular_componentmembrane raft
A0046718biological_processsymbiont entry into host cell
A0046813biological_processreceptor-mediated virion attachment to host cell
A0046872molecular_functionmetal ion binding
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050727biological_processregulation of inflammatory response
A0051957biological_processpositive regulation of amino acid transport
A0060135biological_processmaternal process involved in female pregnancy
A0060452biological_processpositive regulation of cardiac muscle contraction
A0061025biological_processmembrane fusion
A0070062cellular_componentextracellular exosome
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0089718biological_processamino acid import across plasma membrane
A0097746biological_processblood vessel diameter maintenance
A0098670biological_processentry receptor-mediated virion attachment to host cell
A0141109molecular_functiontransporter activator activity
A1903598biological_processpositive regulation of gap junction assembly
A1903779biological_processregulation of cardiac conduction
A1905737biological_processpositive regulation of L-proline import across plasma membrane
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0005298molecular_functionproline:sodium symporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006836biological_processneurotransmitter transport
B0006865biological_processamino acid transport
B0015171molecular_functionamino acid transmembrane transporter activity
B0015175molecular_functionneutral L-amino acid transmembrane transporter activity
B0015188molecular_functionL-isoleucine transmembrane transporter activity
B0015193molecular_functionL-proline transmembrane transporter activity
B0015199molecular_functionamino-acid betaine transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015370molecular_functionsolute:sodium symporter activity
B0015816biological_processglycine transport
B0015824biological_processproline transport
B0015838biological_processamino-acid betaine transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0022857molecular_functiontransmembrane transporter activity
B0035725biological_processsodium ion transmembrane transport
B0089718biological_processamino acid import across plasma membrane
B0150104biological_processtransport across blood-brain barrier
B1903804biological_processglycine import across plasma membrane
B1903806biological_processL-isoleucine import across plasma membrane
B1904271biological_processL-proline import across plasma membrane
B1905647biological_processproline import across plasma membrane
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001618molecular_functionvirus receptor activity
C0001817biological_processregulation of cytokine production
C0002003biological_processangiotensin maturation
C0003051biological_processangiotensin-mediated drinking behavior
C0003081biological_processregulation of systemic arterial blood pressure by renin-angiotensin
C0004175molecular_functionendopeptidase activity
C0004180molecular_functioncarboxypeptidase activity
C0004181molecular_functionmetallocarboxypeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005788cellular_componentendoplasmic reticulum lumen
C0005886cellular_componentplasma membrane
C0005929cellular_componentcilium
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0008237molecular_functionmetallopeptidase activity
C0008241molecular_functionpeptidyl-dipeptidase activity
C0008270molecular_functionzinc ion binding
C0009986cellular_componentcell surface
C0015827biological_processtryptophan transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0016787molecular_functionhydrolase activity
C0019058biological_processviral life cycle
C0019065biological_processreceptor-mediated endocytosis of virus by host cell
C0019229biological_processregulation of vasoconstriction
C0030666cellular_componentendocytic vesicle membrane
C0031526cellular_componentbrush border membrane
C0042127biological_processregulation of cell population proliferation
C0042802molecular_functionidentical protein binding
C0045121cellular_componentmembrane raft
C0046718biological_processsymbiont entry into host cell
C0046813biological_processreceptor-mediated virion attachment to host cell
C0046872molecular_functionmetal ion binding
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0050727biological_processregulation of inflammatory response
C0051957biological_processpositive regulation of amino acid transport
C0060135biological_processmaternal process involved in female pregnancy
C0060452biological_processpositive regulation of cardiac muscle contraction
C0061025biological_processmembrane fusion
C0070062cellular_componentextracellular exosome
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0089718biological_processamino acid import across plasma membrane
C0097746biological_processblood vessel diameter maintenance
C0098670biological_processentry receptor-mediated virion attachment to host cell
C0141109molecular_functiontransporter activator activity
C1903598biological_processpositive regulation of gap junction assembly
C1903779biological_processregulation of cardiac conduction
C1905737biological_processpositive regulation of L-proline import across plasma membrane
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0005298molecular_functionproline:sodium symporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006836biological_processneurotransmitter transport
D0006865biological_processamino acid transport
D0015171molecular_functionamino acid transmembrane transporter activity
D0015175molecular_functionneutral L-amino acid transmembrane transporter activity
D0015188molecular_functionL-isoleucine transmembrane transporter activity
D0015193molecular_functionL-proline transmembrane transporter activity
D0015199molecular_functionamino-acid betaine transmembrane transporter activity
D0015293molecular_functionsymporter activity
D0015370molecular_functionsolute:sodium symporter activity
D0015816biological_processglycine transport
D0015824biological_processproline transport
D0015838biological_processamino-acid betaine transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0022857molecular_functiontransmembrane transporter activity
D0035725biological_processsodium ion transmembrane transport
D0089718biological_processamino acid import across plasma membrane
D0150104biological_processtransport across blood-brain barrier
D1903804biological_processglycine import across plasma membrane
D1903806biological_processL-isoleucine import across plasma membrane
D1904271biological_processL-proline import across plasma membrane
D1905647biological_processproline import across plasma membrane
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ
ChainResidueDetails
ATHR371-GLN380
site_idPS00610
Number of Residues15
DetailsNA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcqmYGGGsF
ChainResidueDetails
BTRP29-PHE43
site_idPS00754
Number of Residues21
DetailsNA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. YLfhSFQdpLPWsvCplngNH
ChainResidueDetails
BTYR112-HIS132
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues470
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues144
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues40
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues40
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01354","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1176
DetailsDomain: {"description":"Peptidase M2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues34
DetailsRegion: {"description":"Interaction with SARS-CoV spike glycoprotein","evidences":[{"source":"PubMed","id":"15791205","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues14
DetailsRegion: {"description":"Essential for cleavage by ADAM17","evidences":[{"source":"PubMed","id":"24227843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues38
DetailsRegion: {"description":"Essential for cleavage by TMPRSS11D and TMPRSS2","evidences":[{"source":"PubMed","id":"24227843","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27217402","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19021774","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues386
DetailsDomain: {"description":"BetaCoV S1-CTD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01269","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32132184","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues4
DetailsRegion: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues142
DetailsRegion: {"description":"Receptor-binding motif; binding to human ACE2","evidences":[{"source":"UniProtKB","id":"P59594","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues16
DetailsRegion: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues70
DetailsRegion: {"description":"Disordered","evidences":[{"source":"PubMed","id":"35108439","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

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