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7Y65

Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0010854molecular_functionadenylate cyclase regulator activity
A0016787molecular_functionhydrolase activity
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0034695biological_processresponse to prostaglandin E
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A0072678biological_processT cell migration
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
D0001774biological_processmicroglial cell activation
D0002430biological_processcomplement receptor mediated signaling pathway
D0002682biological_processregulation of immune system process
D0004875molecular_functioncomplement receptor activity
D0004878molecular_functioncomplement component C5a receptor activity
D0004930molecular_functionG protein-coupled receptor activity
D0005886cellular_componentplasma membrane
D0006935biological_processchemotaxis
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006968biological_processcellular defense response
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007202biological_processobsolete activation of phospholipase C activity
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007606biological_processsensory perception of chemical stimulus
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010759biological_processpositive regulation of macrophage chemotaxis
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0030593biological_processneutrophil chemotaxis
D0030667cellular_componentsecretory granule membrane
D0031410cellular_componentcytoplasmic vesicle
D0032494biological_processresponse to peptidoglycan
D0038178biological_processcomplement component C5a signaling pathway
D0042789biological_processmRNA transcription by RNA polymerase II
D0045177cellular_componentapical part of cell
D0045766biological_processpositive regulation of angiogenesis
D0048143biological_processastrocyte activation
D0050679biological_processpositive regulation of epithelial cell proliferation
D0050830biological_processdefense response to Gram-positive bacterium
D0050890biological_processcognition
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0090023biological_processpositive regulation of neutrophil chemotaxis
D0097242biological_processamyloid-beta clearance
D0099172biological_processpresynapse organization
D1902947biological_processregulation of tau-protein kinase activity
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlLLATISADRFLlV
ChainResidueDetails
DALA122-VAL138

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues93
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:29300009
ChainResidueDetails
DMET1-ASP37
DTHR94-SER110
DARG175-ARG200
DSER266-ASP282

site_idSWS_FT_FI2
Number of Residues26
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DILE38-PHE64
ATHR181

site_idSWS_FT_FI3
Number of Residues39
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29300009
ChainResidueDetails
DGLU65-THR69
DASP133-ALA153
DLEU227-LYS242

site_idSWS_FT_FI4
Number of Residues23
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DILE70-PHE93

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DILE111-ALA132

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DTRP154-TYR174

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DALA201-LEU226

site_idSWS_FT_FI8
Number of Residues22
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DVAL243-MET265

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:29300009
ChainResidueDetails
DSER283-ALA303

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:11342590
ChainResidueDetails
DTYR11
DTYR14

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:7642584
ChainResidueDetails
DSER314

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:7642584
ChainResidueDetails
DSER317
DSER327

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN5

223790

PDB entries from 2024-08-14

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