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7Y5X

CryoEM structure of PS2-containing gamma-secretase treated with MRK-560

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
B0000139cellular_componentGolgi membrane
B0000776cellular_componentkinetochore
B0001666biological_processresponse to hypoxia
B0005515molecular_functionprotein binding
B0005637cellular_componentnuclear inner membrane
B0005769cellular_componentearly endosome
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006509biological_processmembrane protein ectodomain proteolysis
B0007219biological_processNotch signaling pathway
B0007220biological_processNotch receptor processing
B0008021cellular_componentsynaptic vesicle
B0008233molecular_functionpeptidase activity
B0016020cellular_componentmembrane
B0016485biological_processprotein processing
B0032991cellular_componentprotein-containing complex
B0034205biological_processamyloid-beta formation
B0035556biological_processintracellular signal transduction
B0042500molecular_functionaspartic endopeptidase activity, intramembrane cleaving
B0042734cellular_componentpresynaptic membrane
B0042987biological_processamyloid precursor protein catabolic process
B0043227cellular_componentmembrane-bounded organelle
B0055074biological_processcalcium ion homeostasis
B0070765cellular_componentgamma-secretase complex
B0097060cellular_componentsynaptic membrane
B0110097biological_processregulation of calcium import into the mitochondrion
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C0000139cellular_componentGolgi membrane
C0001656biological_processmetanephros development
C0005515molecular_functionprotein binding
C0005769cellular_componentearly endosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006509biological_processmembrane protein ectodomain proteolysis
C0007219biological_processNotch signaling pathway
C0007220biological_processNotch receptor processing
C0008021cellular_componentsynaptic vesicle
C0010008cellular_componentendosome membrane
C0010950biological_processpositive regulation of endopeptidase activity
C0016020cellular_componentmembrane
C0016485biological_processprotein processing
C0019899molecular_functionenzyme binding
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031293biological_processmembrane protein intracellular domain proteolysis
C0032580cellular_componentGolgi cisterna membrane
C0034205biological_processamyloid-beta formation
C0042734cellular_componentpresynaptic membrane
C0042982biological_processamyloid precursor protein metabolic process
C0042987biological_processamyloid precursor protein catabolic process
C0043085biological_processpositive regulation of catalytic activity
C0061133molecular_functionendopeptidase activator activity
C0070765cellular_componentgamma-secretase complex
C0097060cellular_componentsynaptic membrane
D0000139cellular_componentGolgi membrane
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006509biological_processmembrane protein ectodomain proteolysis
D0007219biological_processNotch signaling pathway
D0007220biological_processNotch receptor processing
D0010008cellular_componentendosome membrane
D0010950biological_processpositive regulation of endopeptidase activity
D0016020cellular_componentmembrane
D0016485biological_processprotein processing
D0019899molecular_functionenzyme binding
D0031293biological_processmembrane protein intracellular domain proteolysis
D0032580cellular_componentGolgi cisterna membrane
D0034205biological_processamyloid-beta formation
D0042734cellular_componentpresynaptic membrane
D0042982biological_processamyloid precursor protein metabolic process
D0042987biological_processamyloid precursor protein catabolic process
D0061133molecular_functionendopeptidase activator activity
D0070765cellular_componentgamma-secretase complex
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. VAATrlDsRSFFWNV
ChainResidueDetails
AVAL277-VAL291

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26280335
ChainResidueDetails
DMET1-LYS17
DPHE37-VAL57
CASP140-LEU158
CPRO208-SER213
BLYS410-LEU413
BARG435-ILE448

site_idSWS_FT_FI2
Number of Residues18
DetailsINTRAMEM: Helical => ECO:0000269|PubMed:26280335
ChainResidueDetails
DTYR18-TRP36
BVAL139-LEU159
BPHE167-TYR187
BTYR201-TRP221
BPRO224-ILE244
BTRP250-PRO270
BLEU362-SER382
BLEU389-PHE409

site_idSWS_FT_FI3
Number of Residues20
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:26280335
ChainResidueDetails
DTRP58-PHE78
CTYR90-ALA118
CASP180-ARG186
CSER235-ASP265

site_idSWS_FT_FI4
Number of Residues22
DetailsTOPO_DOM: Lumenal => ECO:0000269|PubMed:26280335, ECO:0000305|PubMed:12639958
ChainResidueDetails
DGLN79-PRO101
AASN187

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26280335
ChainResidueDetails
CTYR69-ALA89
AASN264
AASN435
AASN464
AASN506
AASN530
AASN562
AASN573

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26280335
ChainResidueDetails
CTYR119-ALA139
AASN204
AASN417

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26280335
ChainResidueDetails
CTHR159-PHE179
BSER25

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26280335
ChainResidueDetails
CTYR187-ASN207

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26280335
ChainResidueDetails
CLEU214-GLY234

222415

PDB entries from 2024-07-10

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