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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7Y5L

Crystal structure of human CAF-1 core complex in spacegroup C2

Functional Information from GO Data
ChainGOidnamespacecontents
B0006335biological_processDNA replication-dependent chromatin assembly
C0000118cellular_componenthistone deacetylase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0006335biological_processDNA replication-dependent chromatin assembly
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0007420biological_processbrain development
C0008094molecular_functionATP-dependent activity, acting on DNA
C0008285biological_processnegative regulation of cell population proliferation
C0016581cellular_componentNuRD complex
C0016589cellular_componentNURF complex
C0030336biological_processnegative regulation of cell migration
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0031492molecular_functionnucleosomal DNA binding
C0031507biological_processheterochromatin formation
C0032991cellular_componentprotein-containing complex
C0033186cellular_componentCAF-1 complex
C0035098cellular_componentESC/E(Z) complex
C0042393molecular_functionhistone binding
C0042659biological_processregulation of cell fate specification
C0042826molecular_functionhistone deacetylase binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0070822cellular_componentSin3-type complex
C1902455biological_processnegative regulation of stem cell population maintenance
C1902459biological_processpositive regulation of stem cell population maintenance
C2000736biological_processregulation of stem cell differentiation
E0006335biological_processDNA replication-dependent chromatin assembly
F0000118cellular_componenthistone deacetylase complex
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0006335biological_processDNA replication-dependent chromatin assembly
F0006338biological_processchromatin remodeling
F0006355biological_processregulation of DNA-templated transcription
F0007420biological_processbrain development
F0008094molecular_functionATP-dependent activity, acting on DNA
F0008285biological_processnegative regulation of cell population proliferation
F0016581cellular_componentNuRD complex
F0016589cellular_componentNURF complex
F0030336biological_processnegative regulation of cell migration
F0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
F0031492molecular_functionnucleosomal DNA binding
F0031507biological_processheterochromatin formation
F0032991cellular_componentprotein-containing complex
F0033186cellular_componentCAF-1 complex
F0035098cellular_componentESC/E(Z) complex
F0042393molecular_functionhistone binding
F0042659biological_processregulation of cell fate specification
F0042826molecular_functionhistone deacetylase binding
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0070822cellular_componentSin3-type complex
F1902455biological_processnegative regulation of stem cell population maintenance
F1902459biological_processpositive regulation of stem cell population maintenance
F2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MASAsvDnTAIIWDV
ChainResidueDetails
BMET144-VAL158
CLEU193-ILE207
CLEU289-LEU303
CLEU333-LEU347
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues86
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues78
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues78
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues102
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues82
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues82
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues186
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues98
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues94
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues90
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues86
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues112
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues64
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251174

PDB entries from 2026-03-25

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