7Y5H
Cryo-EM structure of a eukaryotic ZnT8 at a low pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0030658 | cellular_component | transport vesicle membrane |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0062111 | biological_process | zinc ion import into organelle |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0140826 | molecular_function | zinc:proton antiporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006829 | biological_process | zinc ion transport |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0030658 | cellular_component | transport vesicle membrane |
| B | 0030667 | cellular_component | secretory granule membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0062111 | biological_process | zinc ion import into organelle |
| B | 0071577 | biological_process | zinc ion transmembrane transport |
| B | 0140826 | molecular_function | zinc:proton antiporter activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 438 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8IWU4 |
| Chain | Residue | Details |
| B | MET1-LYS67 | |
| B | CYS113-GLU134 | |
| B | HIS191-ALA222 | |
| B | ARG273-GLN374 | |
| A | MET1-LYS67 | |
| A | CYS113-GLU134 | |
| A | HIS191-ALA222 | |
| A | ARG273-GLN374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU68-ILE88 | |
| B | LEU92-LEU112 | |
| B | ILE135-LEU155 | |
| B | THR170-LEU190 | |
| B | PHE223-ILE243 | |
| B | ALA252-LEU272 | |
| A | LEU68-ILE88 | |
| A | LEU92-LEU112 | |
| A | ILE135-LEU155 | |
| A | THR170-LEU190 | |
| A | PHE223-ILE243 | |
| A | ALA252-LEU272 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Lumenal, vesicle => ECO:0000250|UniProtKB:Q8IWU4 |
| Chain | Residue | Details |
| B | ALA89-SER91 | |
| B | ALA156-GLY169 | |
| B | TYR244-MET251 | |
| A | ALA89-SER91 | |
| A | ALA156-GLY169 | |
| A | TYR244-MET251 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: in chain A => ECO:0000250|UniProtKB:Q8IWU4 |
| Chain | Residue | Details |
| B | HIS45 | |
| B | CYS46 | |
| B | HIS47 | |
| A | HIS45 | |
| A | CYS46 | |
| A | HIS47 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8IWU4 |
| Chain | Residue | Details |
| B | HIS100 | |
| B | ASP104 | |
| B | HIS131 | |
| B | HIS225 | |
| B | ASP229 | |
| B | HIS350 | |
| A | HIS100 | |
| A | ASP104 | |
| A | HIS131 | |
| A | HIS225 | |
| A | ASP229 | |
| A | HIS350 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | BINDING: in chain B => ECO:0000250|UniProtKB:Q8IWU4 |
| Chain | Residue | Details |
| B | HIS306 | |
| B | HIS323 | |
| B | GLU357 | |
| B | CYS366 | |
| B | CYS369 | |
| A | HIS306 | |
| A | HIS323 | |
| A | GLU357 | |
| A | CYS366 | |
| A | CYS369 |
