7Y5H
Cryo-EM structure of a eukaryotic ZnT8 at a low pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0009749 | biological_process | response to glucose |
| A | 0010043 | biological_process | response to zinc ion |
| A | 0016020 | cellular_component | membrane |
| A | 0030073 | biological_process | insulin secretion |
| A | 0030658 | cellular_component | transport vesicle membrane |
| A | 0030667 | cellular_component | secretory granule membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0062111 | biological_process | zinc ion import into organelle |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0140826 | molecular_function | zinc:proton antiporter activity |
| B | 0005385 | molecular_function | zinc ion transmembrane transporter activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0009749 | biological_process | response to glucose |
| B | 0010043 | biological_process | response to zinc ion |
| B | 0016020 | cellular_component | membrane |
| B | 0030073 | biological_process | insulin secretion |
| B | 0030658 | cellular_component | transport vesicle membrane |
| B | 0030667 | cellular_component | secretory granule membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0062111 | biological_process | zinc ion import into organelle |
| B | 0071577 | biological_process | zinc ion transmembrane transport |
| B | 0140826 | molecular_function | zinc:proton antiporter activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Topological domain: {"description":"Lumenal, vesicle","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Motif: {"description":"HCH Motif; seals regulatory zinc-binding pocket","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
