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7Y5H

Cryo-EM structure of a eukaryotic ZnT8 at a low pH

Functional Information from GO Data
ChainGOidnamespacecontents
A0005385molecular_functionzinc ion transmembrane transporter activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006829biological_processzinc ion transport
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0009749biological_processresponse to glucose
A0010043biological_processresponse to zinc ion
A0015297molecular_functionantiporter activity
A0016020cellular_componentmembrane
A0030073biological_processinsulin secretion
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031410cellular_componentcytoplasmic vesicle
A0046872molecular_functionmetal ion binding
A0055085biological_processtransmembrane transport
A0062111biological_processzinc ion import into organelle
A0071577biological_processzinc ion transmembrane transport
A0140826molecular_functionzinc:proton antiporter activity
B0005385molecular_functionzinc ion transmembrane transporter activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006829biological_processzinc ion transport
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0009749biological_processresponse to glucose
B0010043biological_processresponse to zinc ion
B0015297molecular_functionantiporter activity
B0016020cellular_componentmembrane
B0030073biological_processinsulin secretion
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031410cellular_componentcytoplasmic vesicle
B0046872molecular_functionmetal ion binding
B0055085biological_processtransmembrane transport
B0062111biological_processzinc ion import into organelle
B0071577biological_processzinc ion transmembrane transport
B0140826molecular_functionzinc:proton antiporter activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues438
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8IWU4
ChainResidueDetails
BMET1-LYS67
BCYS113-GLU134
BHIS191-ALA222
BARG273-GLN374
AMET1-LYS67
ACYS113-GLU134
AHIS191-ALA222
AARG273-GLN374

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BLEU68-ILE88
ATHR170-LEU190
APHE223-ILE243
AALA252-LEU272
BLEU92-LEU112
BILE135-LEU155
BTHR170-LEU190
BPHE223-ILE243
BALA252-LEU272
ALEU68-ILE88
ALEU92-LEU112
AILE135-LEU155

site_idSWS_FT_FI3
Number of Residues44
DetailsTOPO_DOM: Lumenal, vesicle => ECO:0000250|UniProtKB:Q8IWU4
ChainResidueDetails
BALA89-SER91
BALA156-GLY169
BTYR244-MET251
AALA89-SER91
AALA156-GLY169
ATYR244-MET251

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: in chain A => ECO:0000250|UniProtKB:Q8IWU4
ChainResidueDetails
BHIS45
BCYS46
BHIS47
AHIS45
ACYS46
AHIS47

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8IWU4
ChainResidueDetails
BHIS100
AHIS225
AASP229
AHIS350
BASP104
BHIS131
BHIS225
BASP229
BHIS350
AHIS100
AASP104
AHIS131

site_idSWS_FT_FI6
Number of Residues10
DetailsBINDING: in chain B => ECO:0000250|UniProtKB:Q8IWU4
ChainResidueDetails
BHIS306
ACYS369
BHIS323
BGLU357
BCYS366
BCYS369
AHIS306
AHIS323
AGLU357
ACYS366

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PDB entries from 2025-06-11

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