7Y5H

Cryo-EM structure of a eukaryotic ZnT8 at a low pH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006829	biological_process	zinc ion transport
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0009749	biological_process	response to glucose
A	0010043	biological_process	response to zinc ion
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0030073	biological_process	insulin secretion
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0062111	biological_process	zinc ion import into organelle
A	0071577	biological_process	zinc ion transmembrane transport
A	0140826	molecular_function	zinc:proton antiporter activity
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006829	biological_process	zinc ion transport
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0009749	biological_process	response to glucose
B	0010043	biological_process	response to zinc ion
B	0015297	molecular_function	antiporter activity
B	0016020	cellular_component	membrane
B	0030073	biological_process	insulin secretion
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0062111	biological_process	zinc ion import into organelle
B	0071577	biological_process	zinc ion transmembrane transport
B	0140826	molecular_function	zinc:proton antiporter activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Topological domain: {"description":"Lumenal, vesicle","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"HCH Motif; seals regulatory zinc-binding pocket","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"in chain A","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"Q8IWU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---