7Y5G
Cryo-EM structure of a eukaryotic ZnT8 in the presence of zinc
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005886 | cellular_component | plasma membrane |
A | 0006812 | biological_process | monoatomic cation transport |
A | 0006829 | biological_process | zinc ion transport |
A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
A | 0015297 | molecular_function | antiporter activity |
A | 0016020 | cellular_component | membrane |
A | 0030658 | cellular_component | transport vesicle membrane |
A | 0030667 | cellular_component | secretory granule membrane |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0046872 | molecular_function | metal ion binding |
A | 0055085 | biological_process | transmembrane transport |
A | 0062111 | biological_process | zinc ion import into organelle |
A | 0071577 | biological_process | zinc ion transmembrane transport |
A | 0140826 | molecular_function | zinc:proton antiporter activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006812 | biological_process | monoatomic cation transport |
B | 0006829 | biological_process | zinc ion transport |
B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
B | 0015297 | molecular_function | antiporter activity |
B | 0016020 | cellular_component | membrane |
B | 0030658 | cellular_component | transport vesicle membrane |
B | 0030667 | cellular_component | secretory granule membrane |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0046872 | molecular_function | metal ion binding |
B | 0055085 | biological_process | transmembrane transport |
B | 0062111 | biological_process | zinc ion import into organelle |
B | 0071577 | biological_process | zinc ion transmembrane transport |
B | 0140826 | molecular_function | zinc:proton antiporter activity |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 438 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q8IWU4 |
Chain | Residue | Details |
B | MET1-LYS67 | |
B | CYS113-GLU134 | |
B | HIS191-ALA222 | |
B | ARG273-GLN374 | |
A | MET1-LYS67 | |
A | CYS113-GLU134 | |
A | HIS191-ALA222 | |
A | ARG273-GLN374 |
site_id | SWS_FT_FI2 |
Number of Residues | 240 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
B | LEU68-ILE88 | |
B | LEU92-LEU112 | |
B | ILE135-LEU155 | |
B | THR170-LEU190 | |
B | PHE223-ILE243 | |
B | ALA252-LEU272 | |
A | LEU68-ILE88 | |
A | LEU92-LEU112 | |
A | ILE135-LEU155 | |
A | THR170-LEU190 | |
A | PHE223-ILE243 | |
A | ALA252-LEU272 |
site_id | SWS_FT_FI3 |
Number of Residues | 44 |
Details | TOPO_DOM: Lumenal, vesicle => ECO:0000250|UniProtKB:Q8IWU4 |
Chain | Residue | Details |
B | ALA89-SER91 | |
B | ALA156-GLY169 | |
B | TYR244-MET251 | |
A | ALA89-SER91 | |
A | ALA156-GLY169 | |
A | TYR244-MET251 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: in chain A => ECO:0000250|UniProtKB:Q8IWU4 |
Chain | Residue | Details |
B | HIS45 | |
B | CYS46 | |
B | HIS47 | |
A | HIS45 | |
A | CYS46 | |
A | HIS47 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8IWU4 |
Chain | Residue | Details |
B | HIS100 | |
B | ASP104 | |
B | HIS131 | |
B | HIS225 | |
B | ASP229 | |
B | HIS350 | |
A | HIS100 | |
A | ASP104 | |
A | HIS131 | |
A | HIS225 | |
A | ASP229 | |
A | HIS350 |
site_id | SWS_FT_FI6 |
Number of Residues | 10 |
Details | BINDING: in chain B => ECO:0000250|UniProtKB:Q8IWU4 |
Chain | Residue | Details |
B | HIS306 | |
B | HIS323 | |
B | GLU357 | |
B | CYS366 | |
B | CYS369 | |
A | HIS306 | |
A | HIS323 | |
A | GLU357 | |
A | CYS366 | |
A | CYS369 |