Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Y4A

Crystal structure of human ELMO1 RBD-RhoG complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0007015	biological_process	actin filament organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007266	biological_process	Rho protein signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008360	biological_process	regulation of cell shape
A	0016601	biological_process	Rac protein signal transduction
A	0019901	molecular_function	protein kinase binding
A	0030036	biological_process	actin cytoskeleton organization
A	0030667	cellular_component	secretory granule membrane
A	0030865	biological_process	cortical cytoskeleton organization
A	0031410	cellular_component	cytoplasmic vesicle
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0042995	cellular_component	cell projection
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0090630	biological_process	activation of GTPase activity
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	0000166	molecular_function	nucleotide binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0007015	biological_process	actin filament organization
C	0007163	biological_process	establishment or maintenance of cell polarity
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0007266	biological_process	Rho protein signal transduction
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008360	biological_process	regulation of cell shape
C	0016601	biological_process	Rac protein signal transduction
C	0019901	molecular_function	protein kinase binding
C	0030036	biological_process	actin cytoskeleton organization
C	0030667	cellular_component	secretory granule membrane
C	0030865	biological_process	cortical cytoskeleton organization
C	0031410	cellular_component	cytoplasmic vesicle
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0042995	cellular_component	cell projection
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0060326	biological_process	cell chemotaxis
C	0070062	cellular_component	extracellular exosome
C	0090630	biological_process	activation of GTPase activity
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0150052	biological_process	regulation of postsynapse assembly
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	0000166	molecular_function	nucleotide binding
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0007015	biological_process	actin filament organization
E	0007163	biological_process	establishment or maintenance of cell polarity
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0007266	biological_process	Rho protein signal transduction
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008360	biological_process	regulation of cell shape
E	0016601	biological_process	Rac protein signal transduction
E	0019901	molecular_function	protein kinase binding
E	0030036	biological_process	actin cytoskeleton organization
E	0030667	cellular_component	secretory granule membrane
E	0030865	biological_process	cortical cytoskeleton organization
E	0031410	cellular_component	cytoplasmic vesicle
E	0032956	biological_process	regulation of actin cytoskeleton organization
E	0042995	cellular_component	cell projection
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0060326	biological_process	cell chemotaxis
E	0070062	cellular_component	extracellular exosome
E	0090630	biological_process	activation of GTPase activity
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0150052	biological_process	regulation of postsynapse assembly
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	0000166	molecular_function	nucleotide binding
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0007015	biological_process	actin filament organization
G	0007163	biological_process	establishment or maintenance of cell polarity
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0007266	biological_process	Rho protein signal transduction
G	0008284	biological_process	positive regulation of cell population proliferation
G	0008360	biological_process	regulation of cell shape
G	0016601	biological_process	Rac protein signal transduction
G	0019901	molecular_function	protein kinase binding
G	0030036	biological_process	actin cytoskeleton organization
G	0030667	cellular_component	secretory granule membrane
G	0030865	biological_process	cortical cytoskeleton organization
G	0031410	cellular_component	cytoplasmic vesicle
G	0032956	biological_process	regulation of actin cytoskeleton organization
G	0042995	cellular_component	cell projection
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0060326	biological_process	cell chemotaxis
G	0070062	cellular_component	extracellular exosome
G	0090630	biological_process	activation of GTPase activity
G	0098794	cellular_component	postsynapse
G	0098978	cellular_component	glutamatergic synapse
G	0150052	biological_process	regulation of postsynapse assembly
G	1903078	biological_process	positive regulation of protein localization to plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxin TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by HCK","evidences":[{"source":"PubMed","id":"15952790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)