Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7Y13

Cryo-EM structure of apo-state MrgD-Gi complex (local)

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0002033	biological_process	angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
R	0004930	molecular_function	G protein-coupled receptor activity
R	0005506	molecular_function	iron ion binding
R	0005615	cellular_component	extracellular space
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0008528	molecular_function	G protein-coupled peptide receptor activity
R	0009055	molecular_function	electron transfer activity
R	0010614	biological_process	negative regulation of cardiac muscle hypertrophy
R	0016020	cellular_component	membrane
R	0020037	molecular_function	heme binding
R	0022900	biological_process	electron transport chain
R	0042597	cellular_component	periplasmic space
R	0046872	molecular_function	metal ion binding
R	0160025	biological_process	sensory perception of itch

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	39
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	25
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39580805","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y13","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y15","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35840655","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y14","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)