7Y0B

Crystal structure of human short-chain acyl-CoA dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0004085	molecular_function	butyryl-CoA dehydrogenase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005813	cellular_component	centrosome
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0046359	biological_process	butyrate catabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0004085	molecular_function	butyryl-CoA dehydrogenase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005813	cellular_component	centrosome
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0046359	biological_process	butyrate catabolic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0004085	molecular_function	butyryl-CoA dehydrogenase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005813	cellular_component	centrosome
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0046359	biological_process	butyrate catabolic process
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0004085	molecular_function	butyryl-CoA dehydrogenase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005813	cellular_component	centrosome
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0046359	biological_process	butyrate catabolic process
D	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. ALSEpgNGSDagA

Chain	Residue	Details
A	ALA153-ALA165

---

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QiLGGmGYvtEmpaeRhyrD

Chain	Residue	Details
A	GLN365-ASP384

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P15651

Chain	Residue	Details
A	GLU392
B	GLU392
C	GLU392
D	GLU392

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: in other chain => ECO:0000269|Ref.10

Chain	Residue	Details
A	PHE152
A	TRP185
A	GLN308
A	THR394
B	PHE152
B	TRP185
B	GLN308
B	THR394
C	PHE152
C	TRP185
C	GLN308
C	THR394
D	PHE152
D	TRP185
D	GLN308
D	THR394

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	SER161
A	ASP269
A	GLY393
B	SER161
B	ASP269
B	GLY393
C	SER161
C	ASP269
C	GLY393
D	SER161
D	ASP269
D	GLY393

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|Ref.10

Chain	Residue	Details
A	ARG297
A	GLN365
B	ARG297
B	GLN365
C	ARG297
C	GLN365
D	ARG297
D	GLN365

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q07417

Chain	Residue	Details
A	THR27
B	THR27
C	THR27
D	THR27

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q07417

Chain	Residue	Details
A	LYS51
A	LYS129
A	LYS262
A	LYS306
B	LYS51
B	LYS129
B	LYS262
B	LYS306
C	LYS51
C	LYS129
C	LYS262
C	LYS306
D	LYS51
D	LYS129
D	LYS262
D	LYS306

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q07417

Chain	Residue	Details
A	LYS72
A	LYS208
B	LYS72
B	LYS208
C	LYS72
C	LYS208
D	LYS72
D	LYS208

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