7XZZ

Cryo-EM structure of the nucleosome in complex with p53

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0010467	biological_process	gene expression
A	0016020	cellular_component	membrane
A	0030527	molecular_function	structural constituent of chromatin
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0045296	molecular_function	cadherin binding
A	0046982	molecular_function	protein heterodimerization activity
A	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0008285	biological_process	negative regulation of cell population proliferation
C	0030527	molecular_function	structural constituent of chromatin
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0043505	cellular_component	CENP-A containing nucleosome
C	0046982	molecular_function	protein heterodimerization activity
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome
D	0000786	cellular_component	nucleosome
D	0001530	molecular_function	lipopolysaccharide binding
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0043505	cellular_component	CENP-A containing nucleosome
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0010467	biological_process	gene expression
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0045296	molecular_function	cadherin binding
E	0046982	molecular_function	protein heterodimerization activity
E	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0008285	biological_process	negative regulation of cell population proliferation
G	0030527	molecular_function	structural constituent of chromatin
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
G	0043505	cellular_component	CENP-A containing nucleosome
G	0046982	molecular_function	protein heterodimerization activity
G	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0070062	cellular_component	extracellular exosome
H	0000786	cellular_component	nucleosome
H	0001530	molecular_function	lipopolysaccharide binding
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0043505	cellular_component	CENP-A containing nucleosome
H	0046982	molecular_function	protein heterodimerization activity
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000423	biological_process	mitophagy
K	0000785	cellular_component	chromatin
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
K	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
K	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
K	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
K	0001046	molecular_function	core promoter sequence-specific DNA binding
K	0001094	molecular_function	TFIID-class transcription factor complex binding
K	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
K	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
K	0001701	biological_process	in utero embryonic development
K	0001756	biological_process	somitogenesis
K	0001836	biological_process	release of cytochrome c from mitochondria
K	0002020	molecular_function	protease binding
K	0002039	molecular_function	p53 binding
K	0002244	biological_process	hematopoietic progenitor cell differentiation
K	0002309	biological_process	T cell proliferation involved in immune response
K	0002326	biological_process	B cell lineage commitment
K	0002360	biological_process	T cell lineage commitment
K	0002931	biological_process	response to ischemia
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0003730	molecular_function	mRNA 3'-UTR binding
K	0005507	molecular_function	copper ion binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005657	cellular_component	replication fork
K	0005667	cellular_component	transcription regulator complex
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005783	cellular_component	endoplasmic reticulum
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0006289	biological_process	nucleotide-excision repair
K	0006302	biological_process	double-strand break repair
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006606	biological_process	protein import into nucleus
K	0006914	biological_process	autophagy
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
K	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
K	0006979	biological_process	response to oxidative stress
K	0006983	biological_process	ER overload response
K	0007179	biological_process	transforming growth factor beta receptor signaling pathway
K	0007265	biological_process	Ras protein signal transduction
K	0007346	biological_process	regulation of mitotic cell cycle
K	0007369	biological_process	gastrulation
K	0007405	biological_process	neuroblast proliferation
K	0007406	biological_process	negative regulation of neuroblast proliferation
K	0007417	biological_process	central nervous system development
K	0007507	biological_process	heart development
K	0007623	biological_process	circadian rhythm
K	0008104	biological_process	protein localization
K	0008156	biological_process	negative regulation of DNA replication
K	0008270	molecular_function	zinc ion binding
K	0008283	biological_process	cell population proliferation
K	0008285	biological_process	negative regulation of cell population proliferation
K	0008340	biological_process	determination of adult lifespan
K	0009299	biological_process	mRNA transcription
K	0009303	biological_process	rRNA transcription
K	0009410	biological_process	response to xenobiotic stimulus
K	0009411	biological_process	response to UV
K	0009651	biological_process	response to salt stress
K	0009792	biological_process	embryo development ending in birth or egg hatching
K	0010165	biological_process	response to X-ray
K	0010332	biological_process	response to gamma radiation
K	0010628	biological_process	positive regulation of gene expression
K	0010629	biological_process	negative regulation of gene expression
K	0010659	biological_process	cardiac muscle cell apoptotic process
K	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
K	0014009	biological_process	glial cell proliferation
K	0016032	biological_process	viral process
K	0016363	cellular_component	nuclear matrix
K	0016604	cellular_component	nuclear body
K	0016605	cellular_component	PML body
K	0017053	cellular_component	transcription repressor complex
K	0019661	biological_process	glucose catabolic process to lactate via pyruvate
K	0019899	molecular_function	enzyme binding
K	0021549	biological_process	cerebellum development
K	0030308	biological_process	negative regulation of cell growth
K	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
K	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
K	0030971	molecular_function	receptor tyrosine kinase binding
K	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032211	biological_process	negative regulation of telomere maintenance via telomerase
K	0032991	cellular_component	protein-containing complex
K	0033077	biological_process	T cell differentiation in thymus
K	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
K	0033554	biological_process	cellular response to stress
K	0034103	biological_process	regulation of tissue remodeling
K	0034644	biological_process	cellular response to UV
K	0035033	molecular_function	histone deacetylase regulator activity
K	0035264	biological_process	multicellular organism growth
K	0035794	biological_process	positive regulation of mitochondrial membrane permeability
K	0035861	cellular_component	site of double-strand break
K	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
K	0042127	biological_process	regulation of cell population proliferation
K	0042149	biological_process	cellular response to glucose starvation
K	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
K	0042802	molecular_function	identical protein binding
K	0042826	molecular_function	histone deacetylase binding
K	0042981	biological_process	regulation of apoptotic process
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0043073	cellular_component	germ cell nucleus
K	0043153	biological_process	entrainment of circadian clock by photoperiod
K	0043504	biological_process	mitochondrial DNA repair
K	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
K	0043523	biological_process	regulation of neuron apoptotic process
K	0043525	biological_process	positive regulation of neuron apoptotic process
K	0043621	molecular_function	obsolete protein self-association
K	0045815	biological_process	transcription initiation-coupled chromatin remodeling
K	0045861	biological_process	negative regulation of proteolysis
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
K	0045930	biological_process	negative regulation of mitotic cell cycle
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0046677	biological_process	response to antibiotic
K	0046872	molecular_function	metal ion binding
K	0046982	molecular_function	protein heterodimerization activity
K	0048144	biological_process	fibroblast proliferation
K	0048147	biological_process	negative regulation of fibroblast proliferation
K	0048511	biological_process	rhythmic process
K	0048512	biological_process	circadian behavior
K	0048539	biological_process	bone marrow development
K	0048568	biological_process	embryonic organ development
K	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
K	0050821	biological_process	protein stabilization
K	0051087	molecular_function	protein-folding chaperone binding
K	0051097	biological_process	negative regulation of helicase activity
K	0051262	biological_process	protein tetramerization
K	0051276	biological_process	chromosome organization
K	0051402	biological_process	neuron apoptotic process
K	0051721	molecular_function	protein phosphatase 2A binding
K	0051726	biological_process	regulation of cell cycle
K	0060218	biological_process	hematopoietic stem cell differentiation
K	0060253	biological_process	negative regulation of glial cell proliferation
K	0060333	biological_process	type II interferon-mediated signaling pathway
K	0060411	biological_process	cardiac septum morphogenesis
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0062100	biological_process	positive regulation of programmed necrotic cell death
K	0065003	biological_process	protein-containing complex assembly
K	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
K	0070242	biological_process	thymocyte apoptotic process
K	0070243	biological_process	regulation of thymocyte apoptotic process
K	0070245	biological_process	positive regulation of thymocyte apoptotic process
K	0070266	biological_process	necroptotic process
K	0071456	biological_process	cellular response to hypoxia
K	0071466	biological_process	cellular response to xenobiotic stimulus
K	0071479	biological_process	cellular response to ionizing radiation
K	0071480	biological_process	cellular response to gamma radiation
K	0071494	biological_process	cellular response to UV-C
K	0071889	molecular_function	14-3-3 protein binding
K	0072089	biological_process	stem cell proliferation
K	0072331	biological_process	signal transduction by p53 class mediator
K	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
K	0072593	biological_process	reactive oxygen species metabolic process
K	0072717	biological_process	cellular response to actinomycin D
K	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
K	0090398	biological_process	cellular senescence
K	0090399	biological_process	replicative senescence
K	0090403	biological_process	oxidative stress-induced premature senescence
K	0097193	biological_process	intrinsic apoptotic signaling pathway
K	0097252	biological_process	oligodendrocyte apoptotic process
K	0097371	molecular_function	MDM2/MDM4 family protein binding
K	0097718	molecular_function	disordered domain specific binding
K	0140296	molecular_function	general transcription initiation factor binding
K	0140677	molecular_function	molecular function activator activity
K	0140693	molecular_function	molecular condensate scaffold activity
K	1900119	biological_process	positive regulation of execution phase of apoptosis
K	1901525	biological_process	negative regulation of mitophagy
K	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
K	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
K	1902749	biological_process	regulation of cell cycle G2/M phase transition
K	1902895	biological_process	positive regulation of miRNA transcription
K	1903451	biological_process	negative regulation of G1 to G0 transition
K	1903799	biological_process	negative regulation of miRNA processing
K	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
K	1905856	biological_process	negative regulation of pentose-phosphate shunt
K	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
K	1990841	molecular_function	promoter-specific chromatin binding
K	2000269	biological_process	regulation of fibroblast apoptotic process
K	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
K	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
K	2000647	biological_process	negative regulation of stem cell proliferation
K	2000772	biological_process	regulation of cellular senescence
K	2000774	biological_process	positive regulation of cellular senescence
K	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000423	biological_process	mitophagy
L	0000785	cellular_component	chromatin
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
L	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
L	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
L	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
L	0001046	molecular_function	core promoter sequence-specific DNA binding
L	0001094	molecular_function	TFIID-class transcription factor complex binding
L	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
L	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
L	0001701	biological_process	in utero embryonic development
L	0001756	biological_process	somitogenesis
L	0001836	biological_process	release of cytochrome c from mitochondria
L	0002020	molecular_function	protease binding
L	0002039	molecular_function	p53 binding
L	0002244	biological_process	hematopoietic progenitor cell differentiation
L	0002309	biological_process	T cell proliferation involved in immune response
L	0002326	biological_process	B cell lineage commitment
L	0002360	biological_process	T cell lineage commitment
L	0002931	biological_process	response to ischemia
L	0003677	molecular_function	DNA binding
L	0003682	molecular_function	chromatin binding
L	0003700	molecular_function	DNA-binding transcription factor activity
L	0003730	molecular_function	mRNA 3'-UTR binding
L	0005507	molecular_function	copper ion binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005657	cellular_component	replication fork
L	0005667	cellular_component	transcription regulator complex
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005783	cellular_component	endoplasmic reticulum
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0006289	biological_process	nucleotide-excision repair
L	0006302	biological_process	double-strand break repair
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006606	biological_process	protein import into nucleus
L	0006914	biological_process	autophagy
L	0006915	biological_process	apoptotic process
L	0006974	biological_process	DNA damage response
L	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
L	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
L	0006979	biological_process	response to oxidative stress
L	0006983	biological_process	ER overload response
L	0007179	biological_process	transforming growth factor beta receptor signaling pathway
L	0007265	biological_process	Ras protein signal transduction
L	0007346	biological_process	regulation of mitotic cell cycle
L	0007369	biological_process	gastrulation
L	0007405	biological_process	neuroblast proliferation
L	0007406	biological_process	negative regulation of neuroblast proliferation
L	0007417	biological_process	central nervous system development
L	0007507	biological_process	heart development
L	0007623	biological_process	circadian rhythm
L	0008104	biological_process	protein localization
L	0008156	biological_process	negative regulation of DNA replication
L	0008270	molecular_function	zinc ion binding
L	0008283	biological_process	cell population proliferation
L	0008285	biological_process	negative regulation of cell population proliferation
L	0008340	biological_process	determination of adult lifespan
L	0009299	biological_process	mRNA transcription
L	0009303	biological_process	rRNA transcription
L	0009410	biological_process	response to xenobiotic stimulus
L	0009411	biological_process	response to UV
L	0009651	biological_process	response to salt stress
L	0009792	biological_process	embryo development ending in birth or egg hatching
L	0010165	biological_process	response to X-ray
L	0010332	biological_process	response to gamma radiation
L	0010628	biological_process	positive regulation of gene expression
L	0010629	biological_process	negative regulation of gene expression
L	0010659	biological_process	cardiac muscle cell apoptotic process
L	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
L	0014009	biological_process	glial cell proliferation
L	0016032	biological_process	viral process
L	0016363	cellular_component	nuclear matrix
L	0016604	cellular_component	nuclear body
L	0016605	cellular_component	PML body
L	0017053	cellular_component	transcription repressor complex
L	0019661	biological_process	glucose catabolic process to lactate via pyruvate
L	0019899	molecular_function	enzyme binding
L	0021549	biological_process	cerebellum development
L	0030308	biological_process	negative regulation of cell growth
L	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
L	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
L	0030971	molecular_function	receptor tyrosine kinase binding
L	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032211	biological_process	negative regulation of telomere maintenance via telomerase
L	0032991	cellular_component	protein-containing complex
L	0033077	biological_process	T cell differentiation in thymus
L	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
L	0033554	biological_process	cellular response to stress
L	0034103	biological_process	regulation of tissue remodeling
L	0034644	biological_process	cellular response to UV
L	0035033	molecular_function	histone deacetylase regulator activity
L	0035264	biological_process	multicellular organism growth
L	0035794	biological_process	positive regulation of mitochondrial membrane permeability
L	0035861	cellular_component	site of double-strand break
L	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
L	0042127	biological_process	regulation of cell population proliferation
L	0042149	biological_process	cellular response to glucose starvation
L	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
L	0042802	molecular_function	identical protein binding
L	0042826	molecular_function	histone deacetylase binding
L	0042981	biological_process	regulation of apoptotic process
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043073	cellular_component	germ cell nucleus
L	0043153	biological_process	entrainment of circadian clock by photoperiod
L	0043504	biological_process	mitochondrial DNA repair
L	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
L	0043523	biological_process	regulation of neuron apoptotic process
L	0043525	biological_process	positive regulation of neuron apoptotic process
L	0043621	molecular_function	obsolete protein self-association
L	0045815	biological_process	transcription initiation-coupled chromatin remodeling
L	0045861	biological_process	negative regulation of proteolysis
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0045930	biological_process	negative regulation of mitotic cell cycle
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046677	biological_process	response to antibiotic
L	0046872	molecular_function	metal ion binding
L	0046982	molecular_function	protein heterodimerization activity
L	0048144	biological_process	fibroblast proliferation
L	0048147	biological_process	negative regulation of fibroblast proliferation
L	0048511	biological_process	rhythmic process
L	0048512	biological_process	circadian behavior
L	0048539	biological_process	bone marrow development
L	0048568	biological_process	embryonic organ development
L	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
L	0050821	biological_process	protein stabilization
L	0051087	molecular_function	protein-folding chaperone binding
L	0051097	biological_process	negative regulation of helicase activity
L	0051262	biological_process	protein tetramerization
L	0051276	biological_process	chromosome organization
L	0051402	biological_process	neuron apoptotic process
L	0051721	molecular_function	protein phosphatase 2A binding
L	0051726	biological_process	regulation of cell cycle
L	0060218	biological_process	hematopoietic stem cell differentiation
L	0060253	biological_process	negative regulation of glial cell proliferation
L	0060333	biological_process	type II interferon-mediated signaling pathway
L	0060411	biological_process	cardiac septum morphogenesis
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0062100	biological_process	positive regulation of programmed necrotic cell death
L	0065003	biological_process	protein-containing complex assembly
L	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
L	0070242	biological_process	thymocyte apoptotic process
L	0070243	biological_process	regulation of thymocyte apoptotic process
L	0070245	biological_process	positive regulation of thymocyte apoptotic process
L	0070266	biological_process	necroptotic process
L	0071456	biological_process	cellular response to hypoxia
L	0071466	biological_process	cellular response to xenobiotic stimulus
L	0071479	biological_process	cellular response to ionizing radiation
L	0071480	biological_process	cellular response to gamma radiation
L	0071494	biological_process	cellular response to UV-C
L	0071889	molecular_function	14-3-3 protein binding
L	0072089	biological_process	stem cell proliferation
L	0072331	biological_process	signal transduction by p53 class mediator
L	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
L	0072593	biological_process	reactive oxygen species metabolic process
L	0072717	biological_process	cellular response to actinomycin D
L	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
L	0090398	biological_process	cellular senescence
L	0090399	biological_process	replicative senescence
L	0090403	biological_process	oxidative stress-induced premature senescence
L	0097193	biological_process	intrinsic apoptotic signaling pathway
L	0097252	biological_process	oligodendrocyte apoptotic process
L	0097371	molecular_function	MDM2/MDM4 family protein binding
L	0097718	molecular_function	disordered domain specific binding
L	0140296	molecular_function	general transcription initiation factor binding
L	0140677	molecular_function	molecular function activator activity
L	0140693	molecular_function	molecular condensate scaffold activity
L	1900119	biological_process	positive regulation of execution phase of apoptosis
L	1901525	biological_process	negative regulation of mitophagy
L	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
L	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
L	1902749	biological_process	regulation of cell cycle G2/M phase transition
L	1902895	biological_process	positive regulation of miRNA transcription
L	1903451	biological_process	negative regulation of G1 to G0 transition
L	1903799	biological_process	negative regulation of miRNA processing
L	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
L	1905856	biological_process	negative regulation of pentose-phosphate shunt
L	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
L	1990841	molecular_function	promoter-specific chromatin binding
L	2000269	biological_process	regulation of fibroblast apoptotic process
L	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
L	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
L	2000647	biological_process	negative regulation of stem cell proliferation
L	2000772	biological_process	regulation of cellular senescence
L	2000774	biological_process	positive regulation of cellular senescence
L	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000423	biological_process	mitophagy
M	0000785	cellular_component	chromatin
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
M	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
M	0001046	molecular_function	core promoter sequence-specific DNA binding
M	0001094	molecular_function	TFIID-class transcription factor complex binding
M	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
M	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
M	0001701	biological_process	in utero embryonic development
M	0001756	biological_process	somitogenesis
M	0001836	biological_process	release of cytochrome c from mitochondria
M	0002020	molecular_function	protease binding
M	0002039	molecular_function	p53 binding
M	0002244	biological_process	hematopoietic progenitor cell differentiation
M	0002309	biological_process	T cell proliferation involved in immune response
M	0002326	biological_process	B cell lineage commitment
M	0002360	biological_process	T cell lineage commitment
M	0002931	biological_process	response to ischemia
M	0003677	molecular_function	DNA binding
M	0003682	molecular_function	chromatin binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0003730	molecular_function	mRNA 3'-UTR binding
M	0005507	molecular_function	copper ion binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005657	cellular_component	replication fork
M	0005667	cellular_component	transcription regulator complex
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0005783	cellular_component	endoplasmic reticulum
M	0005813	cellular_component	centrosome
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0006289	biological_process	nucleotide-excision repair
M	0006302	biological_process	double-strand break repair
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006606	biological_process	protein import into nucleus
M	0006914	biological_process	autophagy
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
M	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
M	0006979	biological_process	response to oxidative stress
M	0006983	biological_process	ER overload response
M	0007179	biological_process	transforming growth factor beta receptor signaling pathway
M	0007265	biological_process	Ras protein signal transduction
M	0007346	biological_process	regulation of mitotic cell cycle
M	0007369	biological_process	gastrulation
M	0007405	biological_process	neuroblast proliferation
M	0007406	biological_process	negative regulation of neuroblast proliferation
M	0007417	biological_process	central nervous system development
M	0007507	biological_process	heart development
M	0007623	biological_process	circadian rhythm
M	0008104	biological_process	protein localization
M	0008156	biological_process	negative regulation of DNA replication
M	0008270	molecular_function	zinc ion binding
M	0008283	biological_process	cell population proliferation
M	0008285	biological_process	negative regulation of cell population proliferation
M	0008340	biological_process	determination of adult lifespan
M	0009299	biological_process	mRNA transcription
M	0009303	biological_process	rRNA transcription
M	0009410	biological_process	response to xenobiotic stimulus
M	0009411	biological_process	response to UV
M	0009651	biological_process	response to salt stress
M	0009792	biological_process	embryo development ending in birth or egg hatching
M	0010165	biological_process	response to X-ray
M	0010332	biological_process	response to gamma radiation
M	0010628	biological_process	positive regulation of gene expression
M	0010629	biological_process	negative regulation of gene expression
M	0010659	biological_process	cardiac muscle cell apoptotic process
M	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
M	0014009	biological_process	glial cell proliferation
M	0016032	biological_process	viral process
M	0016363	cellular_component	nuclear matrix
M	0016604	cellular_component	nuclear body
M	0016605	cellular_component	PML body
M	0017053	cellular_component	transcription repressor complex
M	0019661	biological_process	glucose catabolic process to lactate via pyruvate
M	0019899	molecular_function	enzyme binding
M	0021549	biological_process	cerebellum development
M	0030308	biological_process	negative regulation of cell growth
M	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
M	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
M	0030971	molecular_function	receptor tyrosine kinase binding
M	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032211	biological_process	negative regulation of telomere maintenance via telomerase
M	0032991	cellular_component	protein-containing complex
M	0033077	biological_process	T cell differentiation in thymus
M	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
M	0033554	biological_process	cellular response to stress
M	0034103	biological_process	regulation of tissue remodeling
M	0034644	biological_process	cellular response to UV
M	0035033	molecular_function	histone deacetylase regulator activity
M	0035264	biological_process	multicellular organism growth
M	0035794	biological_process	positive regulation of mitochondrial membrane permeability
M	0035861	cellular_component	site of double-strand break
M	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
M	0042127	biological_process	regulation of cell population proliferation
M	0042149	biological_process	cellular response to glucose starvation
M	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
M	0042802	molecular_function	identical protein binding
M	0042826	molecular_function	histone deacetylase binding
M	0042981	biological_process	regulation of apoptotic process
M	0043065	biological_process	positive regulation of apoptotic process
M	0043066	biological_process	negative regulation of apoptotic process
M	0043073	cellular_component	germ cell nucleus
M	0043153	biological_process	entrainment of circadian clock by photoperiod
M	0043504	biological_process	mitochondrial DNA repair
M	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
M	0043523	biological_process	regulation of neuron apoptotic process
M	0043525	biological_process	positive regulation of neuron apoptotic process
M	0043621	molecular_function	obsolete protein self-association
M	0045815	biological_process	transcription initiation-coupled chromatin remodeling
M	0045861	biological_process	negative regulation of proteolysis
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0045893	biological_process	positive regulation of DNA-templated transcription
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0045930	biological_process	negative regulation of mitotic cell cycle
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0046677	biological_process	response to antibiotic
M	0046872	molecular_function	metal ion binding
M	0046982	molecular_function	protein heterodimerization activity
M	0048144	biological_process	fibroblast proliferation
M	0048147	biological_process	negative regulation of fibroblast proliferation
M	0048511	biological_process	rhythmic process
M	0048512	biological_process	circadian behavior
M	0048539	biological_process	bone marrow development
M	0048568	biological_process	embryonic organ development
M	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
M	0050821	biological_process	protein stabilization
M	0051087	molecular_function	protein-folding chaperone binding
M	0051097	biological_process	negative regulation of helicase activity
M	0051262	biological_process	protein tetramerization
M	0051276	biological_process	chromosome organization
M	0051402	biological_process	neuron apoptotic process
M	0051721	molecular_function	protein phosphatase 2A binding
M	0051726	biological_process	regulation of cell cycle
M	0060218	biological_process	hematopoietic stem cell differentiation
M	0060253	biological_process	negative regulation of glial cell proliferation
M	0060333	biological_process	type II interferon-mediated signaling pathway
M	0060411	biological_process	cardiac septum morphogenesis
M	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
M	0062100	biological_process	positive regulation of programmed necrotic cell death
M	0065003	biological_process	protein-containing complex assembly
M	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
M	0070242	biological_process	thymocyte apoptotic process
M	0070243	biological_process	regulation of thymocyte apoptotic process
M	0070245	biological_process	positive regulation of thymocyte apoptotic process
M	0070266	biological_process	necroptotic process
M	0071456	biological_process	cellular response to hypoxia
M	0071466	biological_process	cellular response to xenobiotic stimulus
M	0071479	biological_process	cellular response to ionizing radiation
M	0071480	biological_process	cellular response to gamma radiation
M	0071494	biological_process	cellular response to UV-C
M	0071889	molecular_function	14-3-3 protein binding
M	0072089	biological_process	stem cell proliferation
M	0072331	biological_process	signal transduction by p53 class mediator
M	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
M	0072593	biological_process	reactive oxygen species metabolic process
M	0072717	biological_process	cellular response to actinomycin D
M	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
M	0090398	biological_process	cellular senescence
M	0090399	biological_process	replicative senescence
M	0090403	biological_process	oxidative stress-induced premature senescence
M	0097193	biological_process	intrinsic apoptotic signaling pathway
M	0097252	biological_process	oligodendrocyte apoptotic process
M	0097371	molecular_function	MDM2/MDM4 family protein binding
M	0097718	molecular_function	disordered domain specific binding
M	0140296	molecular_function	general transcription initiation factor binding
M	0140677	molecular_function	molecular function activator activity
M	0140693	molecular_function	molecular condensate scaffold activity
M	1900119	biological_process	positive regulation of execution phase of apoptosis
M	1901525	biological_process	negative regulation of mitophagy
M	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
M	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
M	1902749	biological_process	regulation of cell cycle G2/M phase transition
M	1902895	biological_process	positive regulation of miRNA transcription
M	1903451	biological_process	negative regulation of G1 to G0 transition
M	1903799	biological_process	negative regulation of miRNA processing
M	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
M	1905856	biological_process	negative regulation of pentose-phosphate shunt
M	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
M	1990841	molecular_function	promoter-specific chromatin binding
M	2000269	biological_process	regulation of fibroblast apoptotic process
M	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
M	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
M	2000647	biological_process	negative regulation of stem cell proliferation
M	2000772	biological_process	regulation of cellular senescence
M	2000774	biological_process	positive regulation of cellular senescence
M	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000423	biological_process	mitophagy
N	0000785	cellular_component	chromatin
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
N	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
N	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
N	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
N	0001046	molecular_function	core promoter sequence-specific DNA binding
N	0001094	molecular_function	TFIID-class transcription factor complex binding
N	0001227	molecular_function	DNA-binding transcription repressor activity, RNA polymerase II-specific
N	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
N	0001701	biological_process	in utero embryonic development
N	0001756	biological_process	somitogenesis
N	0001836	biological_process	release of cytochrome c from mitochondria
N	0002020	molecular_function	protease binding
N	0002039	molecular_function	p53 binding
N	0002244	biological_process	hematopoietic progenitor cell differentiation
N	0002309	biological_process	T cell proliferation involved in immune response
N	0002326	biological_process	B cell lineage commitment
N	0002360	biological_process	T cell lineage commitment
N	0002931	biological_process	response to ischemia
N	0003677	molecular_function	DNA binding
N	0003682	molecular_function	chromatin binding
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0003730	molecular_function	mRNA 3'-UTR binding
N	0005507	molecular_function	copper ion binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005657	cellular_component	replication fork
N	0005667	cellular_component	transcription regulator complex
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0005783	cellular_component	endoplasmic reticulum
N	0005813	cellular_component	centrosome
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0006289	biological_process	nucleotide-excision repair
N	0006302	biological_process	double-strand break repair
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006606	biological_process	protein import into nucleus
N	0006914	biological_process	autophagy
N	0006915	biological_process	apoptotic process
N	0006974	biological_process	DNA damage response
N	0006977	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
N	0006978	biological_process	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
N	0006979	biological_process	response to oxidative stress
N	0006983	biological_process	ER overload response
N	0007179	biological_process	transforming growth factor beta receptor signaling pathway
N	0007265	biological_process	Ras protein signal transduction
N	0007346	biological_process	regulation of mitotic cell cycle
N	0007369	biological_process	gastrulation
N	0007405	biological_process	neuroblast proliferation
N	0007406	biological_process	negative regulation of neuroblast proliferation
N	0007417	biological_process	central nervous system development
N	0007507	biological_process	heart development
N	0007623	biological_process	circadian rhythm
N	0008104	biological_process	protein localization
N	0008156	biological_process	negative regulation of DNA replication
N	0008270	molecular_function	zinc ion binding
N	0008283	biological_process	cell population proliferation
N	0008285	biological_process	negative regulation of cell population proliferation
N	0008340	biological_process	determination of adult lifespan
N	0009299	biological_process	mRNA transcription
N	0009303	biological_process	rRNA transcription
N	0009410	biological_process	response to xenobiotic stimulus
N	0009411	biological_process	response to UV
N	0009651	biological_process	response to salt stress
N	0009792	biological_process	embryo development ending in birth or egg hatching
N	0010165	biological_process	response to X-ray
N	0010332	biological_process	response to gamma radiation
N	0010628	biological_process	positive regulation of gene expression
N	0010629	biological_process	negative regulation of gene expression
N	0010659	biological_process	cardiac muscle cell apoptotic process
N	0010666	biological_process	positive regulation of cardiac muscle cell apoptotic process
N	0014009	biological_process	glial cell proliferation
N	0016032	biological_process	viral process
N	0016363	cellular_component	nuclear matrix
N	0016604	cellular_component	nuclear body
N	0016605	cellular_component	PML body
N	0017053	cellular_component	transcription repressor complex
N	0019661	biological_process	glucose catabolic process to lactate via pyruvate
N	0019899	molecular_function	enzyme binding
N	0021549	biological_process	cerebellum development
N	0030308	biological_process	negative regulation of cell growth
N	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
N	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
N	0030971	molecular_function	receptor tyrosine kinase binding
N	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0032211	biological_process	negative regulation of telomere maintenance via telomerase
N	0032991	cellular_component	protein-containing complex
N	0033077	biological_process	T cell differentiation in thymus
N	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
N	0033554	biological_process	cellular response to stress
N	0034103	biological_process	regulation of tissue remodeling
N	0034644	biological_process	cellular response to UV
N	0035033	molecular_function	histone deacetylase regulator activity
N	0035264	biological_process	multicellular organism growth
N	0035794	biological_process	positive regulation of mitochondrial membrane permeability
N	0035861	cellular_component	site of double-strand break
N	0036310	molecular_function	ATP-dependent DNA/DNA annealing activity
N	0042127	biological_process	regulation of cell population proliferation
N	0042149	biological_process	cellular response to glucose starvation
N	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
N	0042802	molecular_function	identical protein binding
N	0042826	molecular_function	histone deacetylase binding
N	0042981	biological_process	regulation of apoptotic process
N	0043065	biological_process	positive regulation of apoptotic process
N	0043066	biological_process	negative regulation of apoptotic process
N	0043073	cellular_component	germ cell nucleus
N	0043153	biological_process	entrainment of circadian clock by photoperiod
N	0043504	biological_process	mitochondrial DNA repair
N	0043516	biological_process	regulation of DNA damage response, signal transduction by p53 class mediator
N	0043523	biological_process	regulation of neuron apoptotic process
N	0043525	biological_process	positive regulation of neuron apoptotic process
N	0043621	molecular_function	obsolete protein self-association
N	0045815	biological_process	transcription initiation-coupled chromatin remodeling
N	0045861	biological_process	negative regulation of proteolysis
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
N	0045930	biological_process	negative regulation of mitotic cell cycle
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0046677	biological_process	response to antibiotic
N	0046872	molecular_function	metal ion binding
N	0046982	molecular_function	protein heterodimerization activity
N	0048144	biological_process	fibroblast proliferation
N	0048147	biological_process	negative regulation of fibroblast proliferation
N	0048511	biological_process	rhythmic process
N	0048512	biological_process	circadian behavior
N	0048539	biological_process	bone marrow development
N	0048568	biological_process	embryonic organ development
N	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
N	0050821	biological_process	protein stabilization
N	0051087	molecular_function	protein-folding chaperone binding
N	0051097	biological_process	negative regulation of helicase activity
N	0051262	biological_process	protein tetramerization
N	0051276	biological_process	chromosome organization
N	0051402	biological_process	neuron apoptotic process
N	0051721	molecular_function	protein phosphatase 2A binding
N	0051726	biological_process	regulation of cell cycle
N	0060218	biological_process	hematopoietic stem cell differentiation
N	0060253	biological_process	negative regulation of glial cell proliferation
N	0060333	biological_process	type II interferon-mediated signaling pathway
N	0060411	biological_process	cardiac septum morphogenesis
N	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
N	0062100	biological_process	positive regulation of programmed necrotic cell death
N	0065003	biological_process	protein-containing complex assembly
N	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
N	0070242	biological_process	thymocyte apoptotic process
N	0070243	biological_process	regulation of thymocyte apoptotic process
N	0070245	biological_process	positive regulation of thymocyte apoptotic process
N	0070266	biological_process	necroptotic process
N	0071456	biological_process	cellular response to hypoxia
N	0071466	biological_process	cellular response to xenobiotic stimulus
N	0071479	biological_process	cellular response to ionizing radiation
N	0071480	biological_process	cellular response to gamma radiation
N	0071494	biological_process	cellular response to UV-C
N	0071889	molecular_function	14-3-3 protein binding
N	0072089	biological_process	stem cell proliferation
N	0072331	biological_process	signal transduction by p53 class mediator
N	0072332	biological_process	intrinsic apoptotic signaling pathway by p53 class mediator
N	0072593	biological_process	reactive oxygen species metabolic process
N	0072717	biological_process	cellular response to actinomycin D
N	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
N	0090398	biological_process	cellular senescence
N	0090399	biological_process	replicative senescence
N	0090403	biological_process	oxidative stress-induced premature senescence
N	0097193	biological_process	intrinsic apoptotic signaling pathway
N	0097252	biological_process	oligodendrocyte apoptotic process
N	0097371	molecular_function	MDM2/MDM4 family protein binding
N	0097718	molecular_function	disordered domain specific binding
N	0140296	molecular_function	general transcription initiation factor binding
N	0140677	molecular_function	molecular function activator activity
N	0140693	molecular_function	molecular condensate scaffold activity
N	1900119	biological_process	positive regulation of execution phase of apoptosis
N	1901525	biological_process	negative regulation of mitophagy
N	1902108	biological_process	regulation of mitochondrial membrane permeability involved in apoptotic process
N	1902253	biological_process	regulation of intrinsic apoptotic signaling pathway by p53 class mediator
N	1902749	biological_process	regulation of cell cycle G2/M phase transition
N	1902895	biological_process	positive regulation of miRNA transcription
N	1903451	biological_process	negative regulation of G1 to G0 transition
N	1903799	biological_process	negative regulation of miRNA processing
N	1904024	biological_process	negative regulation of glucose catabolic process to lactate via pyruvate
N	1905856	biological_process	negative regulation of pentose-phosphate shunt
N	1990144	biological_process	intrinsic apoptotic signaling pathway in response to hypoxia
N	1990841	molecular_function	promoter-specific chromatin binding
N	2000269	biological_process	regulation of fibroblast apoptotic process
N	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
N	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
N	2000647	biological_process	negative regulation of stem cell proliferation
N	2000772	biological_process	regulation of cellular senescence
N	2000774	biological_process	positive regulation of cellular senescence
N	2001244	biological_process	positive regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
K	MET237-ARG249

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	760
Details	DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
K	THR102-LYS292
L	THR102-LYS292
M	THR102-LYS292
N	THR102-LYS292

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130

Chain	Residue	Details
K	CYS176
M	HIS179
M	CYS238
M	CYS242
N	CYS176
N	HIS179
N	CYS238
N	CYS242
K	HIS179
K	CYS238
K	CYS242
L	CYS176
L	HIS179
L	CYS238
L	CYS242
M	CYS176

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130

Chain	Residue	Details
K	LYS120
H	LYS8
H	LYS12
H	LYS13
H	LYS17
H	LYS20
H	LYS40
H	LYS82
L	LYS120
M	LYS120
N	LYS120
D	LYS17
D	LYS20
D	LYS40
D	LYS82
H	LYS2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by HIPK4 => ECO:0000269|PubMed:18022393

Chain	Residue	Details
K	SER9
L	SER9
M	SER9
N	SER9

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590

Chain	Residue	Details
K	SER15
L	SER15
M	SER15
N	SER15
F	LYS16
F	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692

Chain	Residue	Details
K	THR18
L	THR18
M	THR18
N	THR18
F	LYS12
F	LYS31
F	LYS77
F	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275

Chain	Residue	Details
K	SER20
L	SER20
M	SER20
N	SER20

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954

Chain	Residue	Details
K	SER33
L	SER33
M	SER33
N	SER33
H	LYS113
H	LYS117

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968

Chain	Residue	Details
K	SER37
L	SER37
M	SER37
N	SER37
G	LYS119
G	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG => ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:17591690

Chain	Residue	Details
K	SER46
L	SER46
M	SER46
N	SER46

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405

Chain	Residue	Details
K	THR55
L	THR55
M	THR55
N	THR55

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	MOD_RES: N6-lactoyllysine => ECO:0000269|PubMed:38653238

Chain	Residue	Details
K	LYS120
K	LYS139
L	LYS120
L	LYS139
M	LYS120
M	LYS139
N	LYS120
N	LYS139

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
K	SER183
K	SER269
L	SER183
L	SER269
M	SER183
M	SER269
N	SER183
N	SER269

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462

Chain	Residue	Details
K	THR284
L	THR284
M	THR284
N	THR284

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314

Chain	Residue	Details
K	LYS305
L	LYS305
M	LYS305
N	LYS305

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: Phosphoserine; by AURKA, CDK1 and CDK2 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:14702041

Chain	Residue	Details
K	SER315
L	SER315
M	SER315
N	SER315
F	LYS59
F	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P02340

Chain	Residue	Details
K	LYS321
L	LYS321
M	LYS321
N	LYS321

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
K	ARG333
L	ARG333
M	ARG333
N	ARG333

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:19011621

Chain	Residue	Details
K	ARG335
K	ARG337
L	ARG335
L	ARG337
M	ARG335
M	ARG337
N	ARG335
N	ARG337

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287

Chain	Residue	Details
K	LYS370
L	LYS370
M	LYS370
N	LYS370

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	MOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881

Chain	Residue	Details
K	LYS372
L	LYS372
M	LYS372
N	LYS372

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795

Chain	Residue	Details
K	LYS373
L	LYS373
M	LYS373
N	LYS373

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861

Chain	Residue	Details
K	LYS381
L	LYS381
M	LYS381
N	LYS381

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	MOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287

Chain	Residue	Details
K	LYS382
L	LYS382
M	LYS382
N	LYS382

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	MOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662, ECO:0000269|PubMed:35618207

Chain	Residue	Details
K	SER392
L	SER392
M	SER392
N	SER392

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459

Chain	Residue	Details
K	LYS24
L	LYS24
M	LYS24
N	LYS24

---

site_id	SWS_FT_FI27
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37

Chain	Residue	Details
A	LYS18
K	LYS386
L	LYS386
M	LYS386
N	LYS386

---

site_id	SWS_FT_FI28
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131

Chain	Residue	Details
K	LYS291
K	LYS292
L	LYS291
L	LYS292
M	LYS291
M	LYS292
N	LYS291
N	LYS292

---

site_id	SWS_FT_FI29
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19033443

Chain	Residue	Details
K	LYS351
K	LYS357
L	LYS351
L	LYS357
M	LYS351
M	LYS357
N	LYS351
N	LYS357

---