7XTK
Cryo-EM structure of SLC19A1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005542 | molecular_function | folic acid binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006855 | biological_process | xenobiotic transmembrane transport |
A | 0007565 | biological_process | female pregnancy |
A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
A | 0008517 | molecular_function | folic acid transmembrane transporter activity |
A | 0008518 | molecular_function | folate:monoatomic anion antiporter activity |
A | 0015297 | molecular_function | antiporter activity |
A | 0015350 | molecular_function | methotrexate transmembrane transporter activity |
A | 0015711 | biological_process | organic anion transport |
A | 0015884 | biological_process | folic acid transport |
A | 0016020 | cellular_component | membrane |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0016324 | cellular_component | apical plasma membrane |
A | 0031526 | cellular_component | brush border membrane |
A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0051180 | biological_process | vitamin transport |
A | 0051958 | biological_process | methotrexate transport |
A | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
A | 0071705 | biological_process | nitrogen compound transport |
A | 0090482 | molecular_function | vitamin transmembrane transporter activity |
A | 0098656 | biological_process | monoatomic anion transmembrane transport |
A | 0098838 | biological_process | folate transmembrane transport |
A | 0140360 | molecular_function | cyclic-GMP-AMP transmembrane transporter activity |
A | 0140361 | biological_process | cyclic-GMP-AMP transmembrane import across plasma membrane |
A | 0141111 | biological_process | positive regulation of cGAS/STING signaling pathway |
A | 0150104 | biological_process | transport across blood-brain barrier |
A | 1904447 | biological_process | folate import across plasma membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 252 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:10347183 |
Chain | Residue | Details |
A | MET1-ARG23 | |
A | LEU90-VAL95 | |
A | ARG145-ALA159 | |
A | LYS204-GLY259 | |
A | LYS328-ARG333 | |
A | LEU379-GLU394 | |
A | LEU455-GLN591 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000305 |
Chain | Residue | Details |
A | SER24-GLY44 |
site_id | SWS_FT_FI3 |
Number of Residues | 78 |
Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:10347183 |
Chain | Residue | Details |
A | GLU45-PRO70 | |
A | ALA117-GLU123 | |
A | GLY178-ASN186 | |
A | VAL288-ALA309 | |
A | HIS355-SER360 | |
A | ASP420-GLN433 |
site_id | SWS_FT_FI4 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000305 |
Chain | Residue | Details |
A | VAL71-TYR89 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000305 |
Chain | Residue | Details |
A | LEU96-VAL116 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000305 |
Chain | Residue | Details |
A | LEU124-VAL144 |
site_id | SWS_FT_FI7 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000305 |
Chain | Residue | Details |
A | VAL160-VAL177 |
site_id | SWS_FT_FI8 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000305 |
Chain | Residue | Details |
A | TYR187-LEU203 |
site_id | SWS_FT_FI9 |
Number of Residues | 27 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000305 |
Chain | Residue | Details |
A | ASP260-TYR287 |
site_id | SWS_FT_FI10 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000305 |
Chain | Residue | Details |
A | ASP310-VAL327 |
site_id | SWS_FT_FI11 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000305 |
Chain | Residue | Details |
A | TRP334-ALA354 |
site_id | SWS_FT_FI12 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000305 |
Chain | Residue | Details |
A | SER361-PHE378 |
site_id | SWS_FT_FI13 |
Number of Residues | 24 |
Details | TRANSMEM: Helical; Name=11 => ECO:0000305 |
Chain | Residue | Details |
A | LEU395-SER419 |
site_id | SWS_FT_FI14 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=12 => ECO:0000305 |
Chain | Residue | Details |
A | LEU434-GLY454 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | MET1 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER5 | |
A | SER225 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41438 |
Chain | Residue | Details |
A | SER474 | |
A | SER485 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER499 | |
A | SER503 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:9767079 |
Chain | Residue | Details |
A | ASN58 |