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7XRD

Cryo-EM structure of Arf6 helical polymer assembled on lipid membrane

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006886biological_processintracellular protein transport
A0007155biological_processcell adhesion
A0007399biological_processnervous system development
A0010975biological_processregulation of neuron projection development
A0010976biological_processpositive regulation of neuron projection development
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030139cellular_componentendocytic vesicle
A0030154biological_processcell differentiation
A0030496cellular_componentmidbody
A0030838biological_processpositive regulation of actin filament polymerization
A0030866biological_processcortical actin cytoskeleton organization
A0031527cellular_componentfilopodium membrane
A0031901cellular_componentearly endosome membrane
A0031996molecular_functionthioesterase binding
A0032154cellular_componentcleavage furrow
A0032456biological_processendocytic recycling
A0034394biological_processprotein localization to cell surface
A0035020biological_processregulation of Rac protein signal transduction
A0035591molecular_functionsignaling adaptor activity
A0036010biological_processprotein localization to endosome
A0042995cellular_componentcell projection
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048488biological_processsynaptic vesicle endocytosis
A0050714biological_processpositive regulation of protein secretion
A0051301biological_processcell division
A0051489biological_processregulation of filopodium assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060998biological_processregulation of dendritic spine development
A0070062cellular_componentextracellular exosome
A0072659biological_processprotein localization to plasma membrane
A0090162biological_processestablishment of epithelial cell polarity
A0090543cellular_componentFlemming body
A0097178biological_processruffle assembly
A0097284biological_processhepatocyte apoptotic process
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099562biological_processmaintenance of postsynaptic density structure
A0120183biological_processpositive regulation of focal adhesion disassembly
A1902217biological_processerythrocyte apoptotic process
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903438biological_processpositive regulation of mitotic cytokinetic process
A1905345biological_processprotein localization to cleavage furrow
A1905606biological_processregulation of presynapse assembly
A1990090biological_processcellular response to nerve growth factor stimulus
A2000009biological_processnegative regulation of protein localization to cell surface
A2000171biological_processnegative regulation of dendrite development
B0001726cellular_componentruffle
B0001889biological_processliver development
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006886biological_processintracellular protein transport
B0007155biological_processcell adhesion
B0007399biological_processnervous system development
B0010975biological_processregulation of neuron projection development
B0010976biological_processpositive regulation of neuron projection development
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0030139cellular_componentendocytic vesicle
B0030154biological_processcell differentiation
B0030496cellular_componentmidbody
B0030838biological_processpositive regulation of actin filament polymerization
B0030866biological_processcortical actin cytoskeleton organization
B0031527cellular_componentfilopodium membrane
B0031901cellular_componentearly endosome membrane
B0031996molecular_functionthioesterase binding
B0032154cellular_componentcleavage furrow
B0032456biological_processendocytic recycling
B0034394biological_processprotein localization to cell surface
B0035020biological_processregulation of Rac protein signal transduction
B0035591molecular_functionsignaling adaptor activity
B0036010biological_processprotein localization to endosome
B0042995cellular_componentcell projection
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0048488biological_processsynaptic vesicle endocytosis
B0050714biological_processpositive regulation of protein secretion
B0051301biological_processcell division
B0051489biological_processregulation of filopodium assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060998biological_processregulation of dendritic spine development
B0070062cellular_componentextracellular exosome
B0072659biological_processprotein localization to plasma membrane
B0090162biological_processestablishment of epithelial cell polarity
B0090543cellular_componentFlemming body
B0097178biological_processruffle assembly
B0097284biological_processhepatocyte apoptotic process
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099562biological_processmaintenance of postsynaptic density structure
B0120183biological_processpositive regulation of focal adhesion disassembly
B1902217biological_processerythrocyte apoptotic process
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1903438biological_processpositive regulation of mitotic cytokinetic process
B1905345biological_processprotein localization to cleavage furrow
B1905606biological_processregulation of presynapse assembly
B1990090biological_processcellular response to nerve growth factor stimulus
B2000009biological_processnegative regulation of protein localization to cell surface
B2000171biological_processnegative regulation of dendrite development
C0001726cellular_componentruffle
C0001889biological_processliver development
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006886biological_processintracellular protein transport
C0007155biological_processcell adhesion
C0007399biological_processnervous system development
C0010975biological_processregulation of neuron projection development
C0010976biological_processpositive regulation of neuron projection development
C0015031biological_processprotein transport
C0016020cellular_componentmembrane
C0016192biological_processvesicle-mediated transport
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0030139cellular_componentendocytic vesicle
C0030154biological_processcell differentiation
C0030496cellular_componentmidbody
C0030838biological_processpositive regulation of actin filament polymerization
C0030866biological_processcortical actin cytoskeleton organization
C0031527cellular_componentfilopodium membrane
C0031901cellular_componentearly endosome membrane
C0031996molecular_functionthioesterase binding
C0032154cellular_componentcleavage furrow
C0032456biological_processendocytic recycling
C0034394biological_processprotein localization to cell surface
C0035020biological_processregulation of Rac protein signal transduction
C0035591molecular_functionsignaling adaptor activity
C0036010biological_processprotein localization to endosome
C0042995cellular_componentcell projection
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048488biological_processsynaptic vesicle endocytosis
C0050714biological_processpositive regulation of protein secretion
C0051301biological_processcell division
C0051489biological_processregulation of filopodium assembly
C0051549biological_processpositive regulation of keratinocyte migration
C0055037cellular_componentrecycling endosome
C0055038cellular_componentrecycling endosome membrane
C0060998biological_processregulation of dendritic spine development
C0070062cellular_componentextracellular exosome
C0072659biological_processprotein localization to plasma membrane
C0090162biological_processestablishment of epithelial cell polarity
C0090543cellular_componentFlemming body
C0097178biological_processruffle assembly
C0097284biological_processhepatocyte apoptotic process
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099562biological_processmaintenance of postsynaptic density structure
C0120183biological_processpositive regulation of focal adhesion disassembly
C1902217biological_processerythrocyte apoptotic process
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1903438biological_processpositive regulation of mitotic cytokinetic process
C1905345biological_processprotein localization to cleavage furrow
C1905606biological_processregulation of presynapse assembly
C1990090biological_processcellular response to nerve growth factor stimulus
C2000009biological_processnegative regulation of protein localization to cell surface
C2000171biological_processnegative regulation of dendrite development
D0001726cellular_componentruffle
D0001889biological_processliver development
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0006886biological_processintracellular protein transport
D0007155biological_processcell adhesion
D0007399biological_processnervous system development
D0010975biological_processregulation of neuron projection development
D0010976biological_processpositive regulation of neuron projection development
D0015031biological_processprotein transport
D0016020cellular_componentmembrane
D0016192biological_processvesicle-mediated transport
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0030139cellular_componentendocytic vesicle
D0030154biological_processcell differentiation
D0030496cellular_componentmidbody
D0030838biological_processpositive regulation of actin filament polymerization
D0030866biological_processcortical actin cytoskeleton organization
D0031527cellular_componentfilopodium membrane
D0031901cellular_componentearly endosome membrane
D0031996molecular_functionthioesterase binding
D0032154cellular_componentcleavage furrow
D0032456biological_processendocytic recycling
D0034394biological_processprotein localization to cell surface
D0035020biological_processregulation of Rac protein signal transduction
D0035591molecular_functionsignaling adaptor activity
D0036010biological_processprotein localization to endosome
D0042995cellular_componentcell projection
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0048488biological_processsynaptic vesicle endocytosis
D0050714biological_processpositive regulation of protein secretion
D0051301biological_processcell division
D0051489biological_processregulation of filopodium assembly
D0051549biological_processpositive regulation of keratinocyte migration
D0055037cellular_componentrecycling endosome
D0055038cellular_componentrecycling endosome membrane
D0060998biological_processregulation of dendritic spine development
D0070062cellular_componentextracellular exosome
D0072659biological_processprotein localization to plasma membrane
D0090162biological_processestablishment of epithelial cell polarity
D0090543cellular_componentFlemming body
D0097178biological_processruffle assembly
D0097284biological_processhepatocyte apoptotic process
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099562biological_processmaintenance of postsynaptic density structure
D0120183biological_processpositive regulation of focal adhesion disassembly
D1902217biological_processerythrocyte apoptotic process
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1903438biological_processpositive regulation of mitotic cytokinetic process
D1905345biological_processprotein localization to cleavage furrow
D1905606biological_processregulation of presynapse assembly
D1990090biological_processcellular response to nerve growth factor stimulus
D2000009biological_processnegative regulation of protein localization to cell surface
D2000171biological_processnegative regulation of dendrite development
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:19644450, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23940353
ChainResidueDetails
AALA23
BCYS155
CALA23
CTHR41
CASP63
CASN122
CCYS155
DALA23
DTHR41
DASP63
DASN122
ATHR41
DCYS155
AASP63
AASN122
ACYS155
BALA23
BTHR41
BASP63
BASN122

site_idSWS_FT_FI2
Number of Residues4
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:7589240
ChainResidueDetails
AGLY2
BGLY2
CGLY2
DGLY2

site_idSWS_FT_FI3
Number of Residues4
DetailsLIPID: N6-myristoyl lysine => ECO:0000269|PubMed:32103017
ChainResidueDetails
ALYS3
BLYS3
CLYS3
DLYS3

223532

PDB entries from 2024-08-07

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