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7XR4

Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate

Functional Information from GO Data
ChainGOidnamespacecontents
A0005313molecular_functionL-glutamate transmembrane transporter activity
A0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006750biological_processglutathione biosynthetic process
A0006811biological_processmonoatomic ion transport
A0006836biological_processneurotransmitter transport
A0006865biological_processamino acid transport
A0007268biological_processchemical synaptic transmission
A0007399biological_processnervous system development
A0007632biological_processvisual behavior
A0008509molecular_functionmonoatomic anion transmembrane transporter activity
A0009410biological_processresponse to xenobiotic stimulus
A0009416biological_processresponse to light stimulus
A0009611biological_processresponse to wounding
A0009986cellular_componentcell surface
A0015175molecular_functionneutral L-amino acid transmembrane transporter activity
A0015179molecular_functionL-amino acid transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015501molecular_functionglutamate:sodium symporter activity
A0015804biological_processneutral amino acid transport
A0015813biological_processL-glutamate transmembrane transport
A0016020cellular_componentmembrane
A0021537biological_processtelencephalon development
A0030424cellular_componentaxon
A0030534biological_processadult behavior
A0030673cellular_componentaxolemma
A0031668biological_processobsolete cellular response to extracellular stimulus
A0031982cellular_componentvesicle
A0033229molecular_functioncysteine transmembrane transporter activity
A0035264biological_processmulticellular organism growth
A0042734cellular_componentpresynaptic membrane
A0043200biological_processresponse to amino acid
A0044297cellular_componentcell body
A0044306cellular_componentneuron projection terminus
A0045121cellular_componentmembrane raft
A0045202cellular_componentsynapse
A0046326biological_processpositive regulation of glucose import
A0046872molecular_functionmetal ion binding
A0070207biological_processprotein homotrimerization
A0070633biological_processtransepithelial transport
A0070778biological_processL-aspartate transmembrane transport
A0070779biological_processD-aspartate import across plasma membrane
A0071314biological_processcellular response to cocaine
A0097449cellular_componentastrocyte projection
A0098656biological_processmonoatomic anion transmembrane transport
A0098712biological_processL-glutamate import across plasma membrane
A0098796cellular_componentmembrane protein complex
A0098810biological_processneurotransmitter reuptake
A0098978cellular_componentglutamatergic synapse
A0140009biological_processL-aspartate import across plasma membrane
A0150104biological_processtransport across blood-brain barrier
A1903712biological_processcysteine transmembrane transport
B0005313molecular_functionL-glutamate transmembrane transporter activity
B0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006750biological_processglutathione biosynthetic process
B0006811biological_processmonoatomic ion transport
B0006836biological_processneurotransmitter transport
B0006865biological_processamino acid transport
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0007632biological_processvisual behavior
B0008509molecular_functionmonoatomic anion transmembrane transporter activity
B0009410biological_processresponse to xenobiotic stimulus
B0009416biological_processresponse to light stimulus
B0009611biological_processresponse to wounding
B0009986cellular_componentcell surface
B0015175molecular_functionneutral L-amino acid transmembrane transporter activity
B0015179molecular_functionL-amino acid transmembrane transporter activity
B0015293molecular_functionsymporter activity
B0015501molecular_functionglutamate:sodium symporter activity
B0015804biological_processneutral amino acid transport
B0015813biological_processL-glutamate transmembrane transport
B0016020cellular_componentmembrane
B0021537biological_processtelencephalon development
B0030424cellular_componentaxon
B0030534biological_processadult behavior
B0030673cellular_componentaxolemma
B0031668biological_processobsolete cellular response to extracellular stimulus
B0031982cellular_componentvesicle
B0033229molecular_functioncysteine transmembrane transporter activity
B0035264biological_processmulticellular organism growth
B0042734cellular_componentpresynaptic membrane
B0043200biological_processresponse to amino acid
B0044297cellular_componentcell body
B0044306cellular_componentneuron projection terminus
B0045121cellular_componentmembrane raft
B0045202cellular_componentsynapse
B0046326biological_processpositive regulation of glucose import
B0046872molecular_functionmetal ion binding
B0070207biological_processprotein homotrimerization
B0070633biological_processtransepithelial transport
B0070778biological_processL-aspartate transmembrane transport
B0070779biological_processD-aspartate import across plasma membrane
B0071314biological_processcellular response to cocaine
B0097449cellular_componentastrocyte projection
B0098656biological_processmonoatomic anion transmembrane transport
B0098712biological_processL-glutamate import across plasma membrane
B0098796cellular_componentmembrane protein complex
B0098810biological_processneurotransmitter reuptake
B0098978cellular_componentglutamatergic synapse
B0140009biological_processL-aspartate import across plasma membrane
B0150104biological_processtransport across blood-brain barrier
B1903712biological_processcysteine transmembrane transport
C0005313molecular_functionL-glutamate transmembrane transporter activity
C0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006750biological_processglutathione biosynthetic process
C0006811biological_processmonoatomic ion transport
C0006836biological_processneurotransmitter transport
C0006865biological_processamino acid transport
C0007268biological_processchemical synaptic transmission
C0007399biological_processnervous system development
C0007632biological_processvisual behavior
C0008509molecular_functionmonoatomic anion transmembrane transporter activity
C0009410biological_processresponse to xenobiotic stimulus
C0009416biological_processresponse to light stimulus
C0009611biological_processresponse to wounding
C0009986cellular_componentcell surface
C0015175molecular_functionneutral L-amino acid transmembrane transporter activity
C0015179molecular_functionL-amino acid transmembrane transporter activity
C0015293molecular_functionsymporter activity
C0015501molecular_functionglutamate:sodium symporter activity
C0015804biological_processneutral amino acid transport
C0015813biological_processL-glutamate transmembrane transport
C0016020cellular_componentmembrane
C0021537biological_processtelencephalon development
C0030424cellular_componentaxon
C0030534biological_processadult behavior
C0030673cellular_componentaxolemma
C0031668biological_processobsolete cellular response to extracellular stimulus
C0031982cellular_componentvesicle
C0033229molecular_functioncysteine transmembrane transporter activity
C0035264biological_processmulticellular organism growth
C0042734cellular_componentpresynaptic membrane
C0043200biological_processresponse to amino acid
C0044297cellular_componentcell body
C0044306cellular_componentneuron projection terminus
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0046326biological_processpositive regulation of glucose import
C0046872molecular_functionmetal ion binding
C0070207biological_processprotein homotrimerization
C0070633biological_processtransepithelial transport
C0070778biological_processL-aspartate transmembrane transport
C0070779biological_processD-aspartate import across plasma membrane
C0071314biological_processcellular response to cocaine
C0097449cellular_componentastrocyte projection
C0098656biological_processmonoatomic anion transmembrane transport
C0098712biological_processL-glutamate import across plasma membrane
C0098796cellular_componentmembrane protein complex
C0098810biological_processneurotransmitter reuptake
C0098978cellular_componentglutamatergic synapse
C0140009biological_processL-aspartate import across plasma membrane
C0150104biological_processtransport across blood-brain barrier
C1903712biological_processcysteine transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00713
Number of Residues15
DetailsNA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GDiLMrMLKMLIlP
ChainResidueDetails
APRO81-PRO95

site_idPS00714
Number of Residues24
DetailsNA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaVaaIFIAQ
ChainResidueDetails
APRO391-GLN414

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues462
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-ASN44
BTHR340-PRO344
BGLU376-ARG384
BTYR494-LYS574
CMET1-ASN44
CASP109-ALA120
CGLY260-ASP268
CTHR340-PRO344
CGLU376-ARG384
CTYR494-LYS574
AASP109-ALA120
AGLY260-ASP268
ATHR340-PRO344
AGLU376-ARG384
ATYR494-LYS574
BMET1-ASN44
BASP109-ALA120
BGLY260-ASP268

site_idSWS_FT_FI2
Number of Residues180
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU45-LEU64
AMET88-LEU108
AMET121-ILE142
BLEU45-LEU64
BMET88-LEU108
BMET121-ILE142
CLEU45-LEU64
CMET88-LEU108
CMET121-ILE142

site_idSWS_FT_FI3
Number of Residues474
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AARG65-ARG87
BLEU459-ASP471
CARG65-ARG87
CHIS143-GLU235
CCYS297-MET317
CILE412-GLN424
CLEU459-ASP471
AHIS143-GLU235
ACYS297-MET317
AILE412-GLN424
ALEU459-ASP471
BARG65-ARG87
BHIS143-GLU235
BCYS297-MET317
BILE412-GLN424

site_idSWS_FT_FI4
Number of Residues69
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE236-MET259
BPHE236-MET259
CPHE236-MET259

site_idSWS_FT_FI5
Number of Residues81
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE269-ILE296
BPHE269-ILE296
CPHE269-ILE296

site_idSWS_FT_FI6
Number of Residues63
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AVAL318-VAL339
BVAL318-VAL339
CVAL318-VAL339

site_idSWS_FT_FI7
Number of Residues189
DetailsINTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE345-LEU375
AILE425-GLY458
BPHE345-LEU375
BILE425-GLY458
CPHE345-LEU375
CILE425-GLY458

site_idSWS_FT_FI8
Number of Residues78
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AVAL385-PHE411
BVAL385-PHE411
CVAL385-PHE411

site_idSWS_FT_FI9
Number of Residues63
DetailsTRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
ATRP472-VAL493
BTRP472-VAL493
CTRP472-VAL493

site_idSWS_FT_FI10
Number of Residues15
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AALA362
BASP475
CALA362
CTHR395
CTHR401
CILE442
CASP475
ATHR395
ATHR401
AILE442
AASP475
BALA362
BTHR395
BTHR401
BILE442

site_idSWS_FT_FI11
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O59010
ChainResidueDetails
AGLY393
CASN397
CASN482
CASP486
AASN397
AASN482
AASP486
BGLY393
BASN397
BASN482
BASP486
CGLY393

site_idSWS_FT_FI12
Number of Residues9
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P31596
ChainResidueDetails
ASER3
ASER21
ASER25
BSER3
BSER21
BSER25
CSER3
CSER21
CSER25

site_idSWS_FT_FI13
Number of Residues21
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P43006
ChainResidueDetails
ASER506
BSER532
BSER534
BSER544
BSER560
BSER564
CSER506
CSER521
CSER532
CSER534
CSER544
ASER521
CSER560
CSER564
ASER532
ASER534
ASER544
ASER560
ASER564
BSER506
BSER521

site_idSWS_FT_FI14
Number of Residues3
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P43006
ChainResidueDetails
ATYR539
BTYR539
CTYR539

site_idSWS_FT_FI15
Number of Residues3
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P43006
ChainResidueDetails
ACYS38
BCYS38
CCYS38

site_idSWS_FT_FI16
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN206
AASN216
BASN206
BASN216
CASN206
CASN216

223166

PDB entries from 2024-07-31

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