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7XQV

The complex of nanobody Rh57 binding to GTP-bound RhoA active form

Functional Information from GO Data
ChainGOidnamespacecontents
A0000902biological_processcell morphogenesis
A0001666biological_processresponse to hypoxia
A0001764biological_processneuron migration
A0001822biological_processkidney development
A0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
A0002363biological_processalpha-beta T cell lineage commitment
A0003100biological_processregulation of systemic arterial blood pressure by endothelin
A0003189biological_processaortic valve formation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007019biological_processmicrotubule depolymerization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0007519biological_processskeletal muscle tissue development
A0008064biological_processregulation of actin polymerization or depolymerization
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0009749biological_processresponse to glucose
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0010975biological_processregulation of neuron projection development
A0010977biological_processnegative regulation of neuron projection development
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0019003molecular_functionGDP binding
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0021795biological_processcerebral cortex cell migration
A0021861biological_processforebrain radial glial cell differentiation
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030154biological_processcell differentiation
A0030307biological_processpositive regulation of cell growth
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030521biological_processandrogen receptor signaling pathway
A0030838biological_processpositive regulation of actin filament polymerization
A0031098biological_processstress-activated protein kinase signaling cascade
A0031122biological_processcytoplasmic microtubule organization
A0031982cellular_componentvesicle
A0032154cellular_componentcleavage furrow
A0032467biological_processpositive regulation of cytokinesis
A0032587cellular_componentruffle membrane
A0032956biological_processregulation of actin cytoskeleton organization
A0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
A0033688biological_processregulation of osteoblast proliferation
A0034329biological_processcell junction assembly
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035385biological_processRoundabout signaling pathway
A0036089biological_processcleavage furrow formation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042476biological_processodontogenesis
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043149biological_processstress fiber assembly
A0043197cellular_componentdendritic spine
A0043200biological_processresponse to amino acid
A0043296cellular_componentapical junction complex
A0043297biological_processapical junction assembly
A0043366biological_processbeta selection
A0043525biological_processpositive regulation of neuron apoptotic process
A0043542biological_processendothelial cell migration
A0043931biological_processossification involved in bone maturation
A0044319biological_processwound healing, spreading of cells
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045471biological_processresponse to ethanol
A0045665biological_processnegative regulation of neuron differentiation
A0045666biological_processpositive regulation of neuron differentiation
A0045727biological_processpositive regulation of translation
A0045785biological_processpositive regulation of cell adhesion
A0045792biological_processnegative regulation of cell size
A0045907biological_processpositive regulation of vasoconstriction
A0045987biological_processpositive regulation of smooth muscle contraction
A0046039biological_processGTP metabolic process
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0048812biological_processneuron projection morphogenesis
A0050773biological_processregulation of dendrite development
A0050919biological_processnegative chemotaxis
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051301biological_processcell division
A0051384biological_processresponse to glucocorticoid
A0051496biological_processpositive regulation of stress fiber assembly
A0051924biological_processregulation of calcium ion transport
A0051964biological_processnegative regulation of synapse assembly
A0061430biological_processbone trabecula morphogenesis
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071393biological_processcellular response to progesterone stimulus
A0071526biological_processsemaphorin-plexin signaling pathway
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090307biological_processmitotic spindle assembly
A0090324biological_processnegative regulation of oxidative phosphorylation
A0097049biological_processmotor neuron apoptotic process
A0097498biological_processendothelial tube lumen extension
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A1902766biological_processskeletal muscle satellite cell migration
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903673biological_processmitotic cleavage furrow formation
A1904695biological_processpositive regulation of vascular associated smooth muscle contraction
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1904753biological_processnegative regulation of vascular associated smooth muscle cell migration
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A1905244biological_processregulation of modification of synaptic structure
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A1990869biological_processcellular response to chemokine
A2000177biological_processregulation of neural precursor cell proliferation
A2000406biological_processpositive regulation of T cell migration
A2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P61586
ChainResidueDetails
AGLY12
AASN117

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
APHE30
AASP59
ASER160

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
ALEU63

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P61586
ChainResidueDetails
ALYS135

222036

PDB entries from 2024-07-03

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