7XQV

The complex of nanobody Rh57 binding to GTP-bound RhoA active form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005938	cellular_component	cell cortex
A	0007019	biological_process	microtubule depolymerization
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007266	biological_process	Rho protein signal transduction
A	0008064	biological_process	regulation of actin polymerization or depolymerization
A	0009410	biological_process	response to xenobiotic stimulus
A	0009612	biological_process	response to mechanical stimulus
A	0009749	biological_process	response to glucose
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010977	biological_process	negative regulation of neuron projection development
A	0016020	cellular_component	membrane
A	0016477	biological_process	cell migration
A	0019003	molecular_function	GDP binding
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030036	biological_process	actin cytoskeleton organization
A	0030307	biological_process	positive regulation of cell growth
A	0030334	biological_process	regulation of cell migration
A	0030335	biological_process	positive regulation of cell migration
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030496	cellular_component	midbody
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0031098	biological_process	stress-activated protein kinase signaling cascade
A	0032154	cellular_component	cleavage furrow
A	0032467	biological_process	positive regulation of cytokinesis
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0034329	biological_process	cell junction assembly
A	0035385	biological_process	Roundabout signaling pathway
A	0036089	biological_process	cleavage furrow formation
A	0043025	cellular_component	neuronal cell body
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043149	biological_process	stress fiber assembly
A	0043197	cellular_component	dendritic spine
A	0043200	biological_process	response to amino acid
A	0043296	cellular_component	apical junction complex
A	0043297	biological_process	apical junction assembly
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044319	biological_process	wound healing, spreading of cells
A	0045198	biological_process	establishment of epithelial cell apical/basal polarity
A	0045471	biological_process	response to ethanol
A	0045665	biological_process	negative regulation of neuron differentiation
A	0045727	biological_process	positive regulation of translation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045907	biological_process	positive regulation of vasoconstriction
A	0045987	biological_process	positive regulation of smooth muscle contraction
A	0046039	biological_process	GTP metabolic process
A	0048812	biological_process	neuron projection morphogenesis
A	0050773	biological_process	regulation of dendrite development
A	0051022	molecular_function	Rho GDP-dissociation inhibitor binding
A	0051384	biological_process	response to glucocorticoid
A	0051924	biological_process	regulation of calcium ion transport
A	0051964	biological_process	negative regulation of synapse assembly
A	0071393	biological_process	cellular response to progesterone stimulus
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	1902766	biological_process	skeletal muscle satellite cell migration
A	1903673	biological_process	mitotic cleavage furrow formation
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
A	1904753	biological_process	negative regulation of vascular associated smooth muscle cell migration
A	1990869	biological_process	cellular response to chemokine
A	2000406	biological_process	positive regulation of T cell migration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Region: {"description":"Switch II region; involved in RAP1GDS1 binding","evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P61586","evidenceCode":"ECO:0000250"}]}

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site_id	SWS_FT_FI4
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}

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