7XQG

Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (GCN conformation)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTqQPGCenVCYD

Chain	Residue	Details
A	CYS54-ASP67

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Ckrd.PCphqVDCFLSRP

Chain	Residue	Details
A	CYS187-PRO203

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	468
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P08050

Chain	Residue	Details
A	GLY2-LYS23
E	TYR98-TYR155
F	GLY2-LYS23
F	TYR98-TYR155
A	TYR98-TYR155
B	GLY2-LYS23
B	TYR98-TYR155
C	GLY2-LYS23
C	TYR98-TYR155
D	GLY2-LYS23
D	TYR98-TYR155
E	GLY2-LYS23

---

site_id	SWS_FT_FI2
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL24-ALA44
C	PHE77-PHE97
C	ILE156-ILE176
C	ILE208-LEU228
D	VAL24-ALA44
D	PHE77-PHE97
D	ILE156-ILE176
D	ILE208-LEU228
E	VAL24-ALA44
E	PHE77-PHE97
E	ILE156-ILE176
A	PHE77-PHE97
E	ILE208-LEU228
F	VAL24-ALA44
F	PHE77-PHE97
F	ILE156-ILE176
F	ILE208-LEU228
A	ILE156-ILE176
A	ILE208-LEU228
B	VAL24-ALA44
B	PHE77-PHE97
B	ILE156-ILE176
B	ILE208-LEU228
C	VAL24-ALA44

---

site_id	SWS_FT_FI3
Number of Residues	366
Details	TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P08050

Chain	Residue	Details
A	TRP45-ARG76
E	TYR177-THR207
F	TRP45-ARG76
F	TYR177-THR207
A	TYR177-THR207
B	TRP45-ARG76
B	TYR177-THR207
C	TRP45-ARG76
C	TYR177-THR207
D	TRP45-ARG76
D	TYR177-THR207
E	TRP45-ARG76

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08050

Chain	Residue	Details
A	SER5
B	SER5
C	SER5
D	SER5
E	SER5
F	SER5

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P23242

Chain	Residue	Details
A	TYR247
B	TYR247
C	TYR247
D	TYR247
E	TYR247
F	TYR247

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15605363, ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER255
B	SER255
C	SER255
D	SER255
E	SER255
F	SER255

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:22411987

Chain	Residue	Details
A	LYS144
D	LYS144
D	LYS237
E	LYS144
E	LYS237
F	LYS144
F	LYS237
A	LYS237
B	LYS144
B	LYS237
C	LYS144
C	LYS237

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