7XN7

RNA polymerase II elongation complex containing Spt4/5, Elf1, Spt6, Spn1 and Paf1C

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0006325	biological_process	chromatin organization
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006369	biological_process	termination of RNA polymerase II transcription
A	0030643	biological_process	intracellular phosphate ion homeostasis
A	0034062	molecular_function	5'-3' RNA polymerase activity
A	0140463	molecular_function	chromatin-protein adaptor activity
A	0180034	biological_process	co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway
B	0001172	biological_process	RNA-templated transcription
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0001172	biological_process	RNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006369	biological_process	termination of RNA polymerase II transcription
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D	0000932	cellular_component	P-body
D	0001172	biological_process	RNA-templated transcription
D	0003697	molecular_function	single-stranded DNA binding
D	0003727	molecular_function	single-stranded RNA binding
D	0003899	molecular_function	DNA-directed RNA polymerase activity
D	0003968	molecular_function	RNA-directed RNA polymerase activity
D	0005634	cellular_component	nucleus
D	0005665	cellular_component	RNA polymerase II, core complex
D	0005737	cellular_component	cytoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030880	cellular_component	RNA polymerase complex
D	0031369	molecular_function	translation initiation factor binding
D	0045948	biological_process	positive regulation of translational initiation
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006383	biological_process	transcription by RNA polymerase III
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000932	cellular_component	P-body
G	0000956	biological_process	nuclear-transcribed mRNA catabolic process
G	0001172	biological_process	RNA-templated transcription
G	0003676	molecular_function	nucleic acid binding
G	0003697	molecular_function	single-stranded DNA binding
G	0003727	molecular_function	single-stranded RNA binding
G	0003968	molecular_function	RNA-directed RNA polymerase activity
G	0005634	cellular_component	nucleus
G	0005665	cellular_component	RNA polymerase II, core complex
G	0005737	cellular_component	cytoplasm
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0010590	biological_process	regulation of septum digestion after cytokinesis
G	0031369	molecular_function	translation initiation factor binding
G	0045948	biological_process	positive regulation of translational initiation
G	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
H	0001172	biological_process	RNA-templated transcription
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0003968	molecular_function	RNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
H	0006360	biological_process	transcription by RNA polymerase I
H	0006361	biological_process	transcription initiation at RNA polymerase I promoter
H	0006362	biological_process	transcription elongation by RNA polymerase I
H	0006363	biological_process	termination of RNA polymerase I transcription
H	0006366	biological_process	transcription by RNA polymerase II
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006383	biological_process	transcription by RNA polymerase III
H	0006384	biological_process	transcription initiation at RNA polymerase III promoter
H	0006386	biological_process	termination of RNA polymerase III transcription
H	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
H	0042797	biological_process	tRNA transcription by RNA polymerase III
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006361	biological_process	transcription initiation at RNA polymerase I promoter
J	0006362	biological_process	transcription elongation by RNA polymerase I
J	0006363	biological_process	termination of RNA polymerase I transcription
J	0006366	biological_process	transcription by RNA polymerase II
J	0006367	biological_process	transcription initiation at RNA polymerase II promoter
J	0006383	biological_process	transcription by RNA polymerase III
J	0008270	molecular_function	zinc ion binding
J	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
J	0042797	biological_process	tRNA transcription by RNA polymerase III
K	0001172	biological_process	RNA-templated transcription
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0003968	molecular_function	RNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0006367	biological_process	transcription initiation at RNA polymerase II promoter
K	0006368	biological_process	transcription elongation by RNA polymerase II
K	0006369	biological_process	termination of RNA polymerase II transcription
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0008270	molecular_function	zinc ion binding
m	0000082	biological_process	G1/S transition of mitotic cell cycle
m	0000122	biological_process	negative regulation of transcription by RNA polymerase II
m	0000791	cellular_component	euchromatin
m	0001073	molecular_function	transcription antitermination factor activity, DNA binding
m	0003676	molecular_function	nucleic acid binding
m	0003677	molecular_function	DNA binding
m	0005634	cellular_component	nucleus
m	0005694	cellular_component	chromosome
m	0005721	cellular_component	pericentric heterochromatin
m	0006139	biological_process	nucleobase-containing compound metabolic process
m	0006334	biological_process	nucleosome assembly
m	0006338	biological_process	chromatin remodeling
m	0006366	biological_process	transcription by RNA polymerase II
m	0006368	biological_process	transcription elongation by RNA polymerase II
m	0008023	cellular_component	transcription elongation factor complex
m	0016973	biological_process	poly(A)+ mRNA export from nucleus
m	0031440	biological_process	regulation of mRNA 3'-end processing
m	0031491	molecular_function	nucleosome binding
m	0031564	biological_process	transcription antitermination
m	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
m	0033554	biological_process	cellular response to stress
m	0034728	biological_process	nucleosome organization
m	0042393	molecular_function	histone binding
m	0140673	biological_process	transcription elongation-coupled chromatin remodeling
M	0000993	molecular_function	RNA polymerase II complex binding
M	0005634	cellular_component	nucleus
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0008023	cellular_component	transcription elongation factor complex
M	0045815	biological_process	transcription initiation-coupled chromatin remodeling
n	0005634	cellular_component	nucleus
n	0016973	biological_process	poly(A)+ mRNA export from nucleus
q	0000082	biological_process	G1/S transition of mitotic cell cycle
q	0000791	cellular_component	euchromatin
q	0000993	molecular_function	RNA polymerase II complex binding
q	0001015	biological_process	snoRNA transcription by RNA polymerase II
q	0003712	molecular_function	transcription coregulator activity
q	0005634	cellular_component	nucleus
q	0006353	biological_process	DNA-templated transcription termination
q	0006355	biological_process	regulation of DNA-templated transcription
q	0006357	biological_process	regulation of transcription by RNA polymerase II
q	0006360	biological_process	transcription by RNA polymerase I
q	0006362	biological_process	transcription elongation by RNA polymerase I
q	0006368	biological_process	transcription elongation by RNA polymerase II
q	0009302	biological_process	sno(s)RNA transcription
q	0016593	cellular_component	Cdc73/Paf1 complex
q	0031124	biological_process	mRNA 3'-end processing
q	0031126	biological_process	sno(s)RNA 3'-end processing
q	0045142	molecular_function	triplex DNA binding
q	0060260	biological_process	regulation of transcription initiation by RNA polymerase II
q	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
q	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
q	1901525	biological_process	negative regulation of mitophagy
q	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
q	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
r	0003677	molecular_function	DNA binding
u	0005634	cellular_component	nucleus
u	0006368	biological_process	transcription elongation by RNA polymerase II
u	0016593	cellular_component	Cdc73/Paf1 complex
u	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
u	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
v	0000082	biological_process	G1/S transition of mitotic cell cycle
v	0000122	biological_process	negative regulation of transcription by RNA polymerase II
v	0000183	biological_process	rDNA heterochromatin formation
v	0000791	cellular_component	euchromatin
v	0000993	molecular_function	RNA polymerase II complex binding
v	0001015	biological_process	snoRNA transcription by RNA polymerase II
v	0003682	molecular_function	chromatin binding
v	0005634	cellular_component	nucleus
v	0006353	biological_process	DNA-templated transcription termination
v	0006357	biological_process	regulation of transcription by RNA polymerase II
v	0006360	biological_process	transcription by RNA polymerase I
v	0006362	biological_process	transcription elongation by RNA polymerase I
v	0006364	biological_process	rRNA processing
v	0006368	biological_process	transcription elongation by RNA polymerase II
v	0006383	biological_process	transcription by RNA polymerase III
v	0009302	biological_process	sno(s)RNA transcription
v	0016593	cellular_component	Cdc73/Paf1 complex
v	0031124	biological_process	mRNA 3'-end processing
v	0031126	biological_process	sno(s)RNA 3'-end processing
v	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
v	0045910	biological_process	negative regulation of DNA recombination
v	0070911	biological_process	global genome nucleotide-excision repair
v	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
v	1901525	biological_process	negative regulation of mitophagy
v	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
v	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
V	0000182	molecular_function	rDNA binding
V	0000775	cellular_component	chromosome, centromeric region
V	0000776	cellular_component	kinetochore
V	0000993	molecular_function	RNA polymerase II complex binding
V	0003727	molecular_function	single-stranded RNA binding
V	0005634	cellular_component	nucleus
V	0006325	biological_process	chromatin organization
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0006370	biological_process	7-methylguanosine mRNA capping
V	0008270	molecular_function	zinc ion binding
V	0008298	biological_process	intracellular mRNA localization
V	0010507	biological_process	negative regulation of autophagy
V	0031507	biological_process	heterochromatin formation
V	0031934	cellular_component	mating-type region heterochromatin
V	0032044	cellular_component	DSIF complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0033553	cellular_component	rDNA heterochromatin
V	0044877	molecular_function	protein-containing complex binding
V	0090262	biological_process	regulation of transcription-coupled nucleotide-excision repair
V	0140673	biological_process	transcription elongation-coupled chromatin remodeling
V	2000232	biological_process	regulation of rRNA processing
V	2001208	biological_process	negative regulation of transcription elongation by RNA polymerase I
V	2001209	biological_process	positive regulation of transcription elongation by RNA polymerase I
W	0003711	molecular_function	transcription elongation factor activity
W	0003729	molecular_function	mRNA binding
W	0005634	cellular_component	nucleus
W	0006325	biological_process	chromatin organization
W	0006354	biological_process	DNA-templated transcription elongation
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0032044	cellular_component	DSIF complex
W	0032784	biological_process	regulation of DNA-templated transcription elongation
W	0140463	molecular_function	chromatin-protein adaptor activity
x	0000993	molecular_function	RNA polymerase II complex binding
x	0005634	cellular_component	nucleus
x	0006368	biological_process	transcription elongation by RNA polymerase II
x	0016593	cellular_component	Cdc73/Paf1 complex
x	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
A	TYR1560-SER1566
A	TYR1567-SER1573
A	TYR1574-SER1580
A	TYR1581-SER1587
A	TYR1588-SER1594
A	TYR1595-SER1601
A	TYR1602-SER1608
A	TYR1609-SER1615
A	TYR1616-SER1622

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site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSLRRtmlaevptlAidlVeikmNtSvlaDEfIShRLGLIP

Chain	Residue	Details
C	ASN30-PRO70

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site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCLECNNMLypkedkenqrllysCrnC

Chain	Residue	Details
I	PHE6-CYS32

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site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPKHirLsdGE

Chain	Residue	Details
E	HIS146-GLU159

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site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARiLGtRAlQ

Chain	Residue	Details
F	THR86-GLN100

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site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFSCG

Chain	Residue	Details
J	ILE2-GLY11

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site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. FerEdHTLaNlLreeLalypdVtfvaYkveHP

Chain	Residue	Details
K	PHE35-PRO66

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site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY977-THR989

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