Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7XN3

E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002189	cellular_component	ribose phosphate diphosphokinase complex
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0034214	biological_process	protein hexamerization
A	0042301	molecular_function	phosphate ion binding
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0044249	biological_process	cellular biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0002189	cellular_component	ribose phosphate diphosphokinase complex
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0034214	biological_process	protein hexamerization
B	0042301	molecular_function	phosphate ion binding
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0044249	biological_process	cellular biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0002189	cellular_component	ribose phosphate diphosphokinase complex
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0034214	biological_process	protein hexamerization
C	0042301	molecular_function	phosphate ion binding
C	0042802	molecular_function	identical protein binding
C	0043531	molecular_function	ADP binding
C	0044249	biological_process	cellular biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0002189	cellular_component	ribose phosphate diphosphokinase complex
D	0004749	molecular_function	ribose phosphate diphosphokinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0034214	biological_process	protein hexamerization
D	0042301	molecular_function	phosphate ion binding
D	0042802	molecular_function	identical protein binding
D	0043531	molecular_function	ADP binding
D	0044249	biological_process	cellular biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0002189	cellular_component	ribose phosphate diphosphokinase complex
E	0004749	molecular_function	ribose phosphate diphosphokinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
E	0009165	biological_process	nucleotide biosynthetic process
E	0016301	molecular_function	kinase activity
E	0034214	biological_process	protein hexamerization
E	0042301	molecular_function	phosphate ion binding
E	0042802	molecular_function	identical protein binding
E	0043531	molecular_function	ADP binding
E	0044249	biological_process	cellular biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0002189	cellular_component	ribose phosphate diphosphokinase complex
F	0004749	molecular_function	ribose phosphate diphosphokinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006015	biological_process	5-phosphoribose 1-diphosphate biosynthetic process
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
F	0009165	biological_process	nucleotide biosynthetic process
F	0016301	molecular_function	kinase activity
F	0034214	biological_process	protein hexamerization
F	0042301	molecular_function	phosphate ion binding
F	0042802	molecular_function	identical protein binding
F	0043531	molecular_function	ADP binding
F	0044249	biological_process	cellular biosynthetic process
F	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. CVLVDDMIDTGgT

Chain	Residue	Details
A	CYS216-THR228

site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAeQIQGFFdvPVD

Chain	Residue	Details
A	ASP129-ASP144

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:7657655

Chain	Residue	Details
A	LYS194
B	LYS194
F	LYS194
E	LYS194
C	LYS194
D	LYS194

site_id	SWS_FT_FI2
Number of Residues	42
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00583

Chain	Residue	Details
A	ASP224
B	ASP37
B	ARG96
B	HIS131
B	ASP170
B	ARG196
B	ASP220
B	ASP224
F	ASP37
F	ARG96
F	HIS131
F	ASP170
F	ARG196
F	ASP220
F	ASP224
E	ASP37
E	ARG96
E	HIS131
E	ASP170
E	ARG196
E	ASP220
E	ASP224
C	ASP37
C	ARG96
C	HIS131
C	ASP170
C	ARG196
C	ASP220
C	ASP224
D	ASP37
D	ARG96
D	HIS131
D	ASP170
D	ARG196
D	ASP220
D	ASP224
A	ASP37
A	ARG96
A	HIS131
A	ASP170
A	ARG196
A	ASP220

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)