7XLO

Crystal Structure of the Catalytic Domain of Inosine Monophosphate Dehydrogenase (IMPDH) from Methanocaldococcus jannaschii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LKVGIGpGSICtT

Chain	Residue	Details
A	LEU190-THR202

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	CYS200
B	CYS200

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	ARG299
B	ARG299

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site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	SER198
A	ASP233
A	GLY256
A	TYR280
A	GLU317
A	GLU371
A	SER372
A	HIS373
B	ASP141
B	GLY193
B	SER198
B	ASP233
B	GLY256
B	TYR280
B	GLU317
B	GLU371
B	SER372
B	HIS373
A	ASP141
A	GLY193

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY195
A	GLY197
A	CYS200
B	GLY195
B	GLY197
B	CYS200

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