7XLB
Cryo-EM structure of human pannexin 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0015267 | molecular_function | channel activity |
| A | 0032732 | biological_process | positive regulation of interleukin-1 production |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0015267 | molecular_function | channel activity |
| B | 0032732 | biological_process | positive regulation of interleukin-1 production |
| C | 0006812 | biological_process | monoatomic cation transport |
| C | 0015267 | molecular_function | channel activity |
| C | 0032732 | biological_process | positive regulation of interleukin-1 production |
| D | 0006812 | biological_process | monoatomic cation transport |
| D | 0015267 | molecular_function | channel activity |
| D | 0032732 | biological_process | positive regulation of interleukin-1 production |
| E | 0006812 | biological_process | monoatomic cation transport |
| E | 0015267 | molecular_function | channel activity |
| E | 0032732 | biological_process | positive regulation of interleukin-1 production |
| F | 0006812 | biological_process | monoatomic cation transport |
| F | 0015267 | molecular_function | channel activity |
| F | 0032732 | biological_process | positive regulation of interleukin-1 production |
| G | 0006812 | biological_process | monoatomic cation transport |
| G | 0015267 | molecular_function | channel activity |
| G | 0032732 | biological_process | positive regulation of interleukin-1 production |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 805 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| E | MET11-GLU47 | |
| D | SER147-LEU226 | |
| F | MET11-GLU47 | |
| F | SER147-LEU226 | |
| G | MET11-GLU47 | |
| G | SER147-LEU226 | |
| E | SER147-LEU226 | |
| A | MET11-GLU47 | |
| A | SER147-LEU226 | |
| B | MET11-GLU47 | |
| B | SER147-LEU226 | |
| C | MET11-GLU47 | |
| C | SER147-LEU226 | |
| D | MET11-GLU47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 616 |
| Details | TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351 |
| Chain | Residue | Details |
| E | LEU48-PHE70 | |
| B | LEU124-ALA146 | |
| B | TYR227-TYR249 | |
| B | VAL293-PHE315 | |
| C | LEU48-PHE70 | |
| C | LEU124-ALA146 | |
| C | TYR227-TYR249 | |
| C | VAL293-PHE315 | |
| D | LEU48-PHE70 | |
| D | LEU124-ALA146 | |
| D | TYR227-TYR249 | |
| E | LEU124-ALA146 | |
| D | VAL293-PHE315 | |
| F | LEU48-PHE70 | |
| F | LEU124-ALA146 | |
| F | TYR227-TYR249 | |
| F | VAL293-PHE315 | |
| G | LEU48-PHE70 | |
| G | LEU124-ALA146 | |
| G | TYR227-TYR249 | |
| G | VAL293-PHE315 | |
| E | TYR227-TYR249 | |
| E | VAL293-PHE315 | |
| A | LEU48-PHE70 | |
| A | LEU124-ALA146 | |
| A | TYR227-TYR249 | |
| A | VAL293-PHE315 | |
| B | LEU48-PHE70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 658 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| E | THR71-PHE123 | |
| D | ALA250-GLY292 | |
| F | THR71-PHE123 | |
| F | ALA250-GLY292 | |
| G | THR71-PHE123 | |
| G | ALA250-GLY292 | |
| E | ALA250-GLY292 | |
| A | THR71-PHE123 | |
| A | ALA250-GLY292 | |
| B | THR71-PHE123 | |
| B | ALA250-GLY292 | |
| C | THR71-PHE123 | |
| C | ALA250-GLY292 | |
| D | THR71-PHE123 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| E | ASN86 | |
| A | ASN86 | |
| B | ASN86 | |
| C | ASN86 | |
| D | ASN86 | |
| F | ASN86 | |
| G | ASN86 |
