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7XL8

Human Cx36/GJD2 (N-terminal deletion mutant) gap junction channel in soybean lipids (D6 symmetry)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007268biological_processchemical synaptic transmission
A0007601biological_processvisual perception
A0019228biological_processneuronal action potential
A0045202cellular_componentsynapse
A0055085biological_processtransmembrane transport
B0005243molecular_functiongap junction channel activity
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007268biological_processchemical synaptic transmission
B0007601biological_processvisual perception
B0019228biological_processneuronal action potential
B0045202cellular_componentsynapse
B0055085biological_processtransmembrane transport
C0005243molecular_functiongap junction channel activity
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007268biological_processchemical synaptic transmission
C0007601biological_processvisual perception
C0019228biological_processneuronal action potential
C0045202cellular_componentsynapse
C0055085biological_processtransmembrane transport
D0005243molecular_functiongap junction channel activity
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007268biological_processchemical synaptic transmission
D0007601biological_processvisual perception
D0019228biological_processneuronal action potential
D0045202cellular_componentsynapse
D0055085biological_processtransmembrane transport
E0005243molecular_functiongap junction channel activity
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007268biological_processchemical synaptic transmission
E0007601biological_processvisual perception
E0019228biological_processneuronal action potential
E0045202cellular_componentsynapse
E0055085biological_processtransmembrane transport
F0005243molecular_functiongap junction channel activity
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007268biological_processchemical synaptic transmission
F0007601biological_processvisual perception
F0019228biological_processneuronal action potential
F0045202cellular_componentsynapse
F0055085biological_processtransmembrane transport
G0005243molecular_functiongap junction channel activity
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0005922cellular_componentconnexin complex
G0007154biological_processcell communication
G0007267biological_processcell-cell signaling
G0007268biological_processchemical synaptic transmission
G0007601biological_processvisual perception
G0019228biological_processneuronal action potential
G0045202cellular_componentsynapse
G0055085biological_processtransmembrane transport
H0005243molecular_functiongap junction channel activity
H0005886cellular_componentplasma membrane
H0005921cellular_componentgap junction
H0005922cellular_componentconnexin complex
H0007154biological_processcell communication
H0007267biological_processcell-cell signaling
H0007268biological_processchemical synaptic transmission
H0007601biological_processvisual perception
H0019228biological_processneuronal action potential
H0045202cellular_componentsynapse
H0055085biological_processtransmembrane transport
I0005243molecular_functiongap junction channel activity
I0005886cellular_componentplasma membrane
I0005921cellular_componentgap junction
I0005922cellular_componentconnexin complex
I0007154biological_processcell communication
I0007267biological_processcell-cell signaling
I0007268biological_processchemical synaptic transmission
I0007601biological_processvisual perception
I0019228biological_processneuronal action potential
I0045202cellular_componentsynapse
I0055085biological_processtransmembrane transport
J0005243molecular_functiongap junction channel activity
J0005886cellular_componentplasma membrane
J0005921cellular_componentgap junction
J0005922cellular_componentconnexin complex
J0007154biological_processcell communication
J0007267biological_processcell-cell signaling
J0007268biological_processchemical synaptic transmission
J0007601biological_processvisual perception
J0019228biological_processneuronal action potential
J0045202cellular_componentsynapse
J0055085biological_processtransmembrane transport
K0005243molecular_functiongap junction channel activity
K0005886cellular_componentplasma membrane
K0005921cellular_componentgap junction
K0005922cellular_componentconnexin complex
K0007154biological_processcell communication
K0007267biological_processcell-cell signaling
K0007268biological_processchemical synaptic transmission
K0007601biological_processvisual perception
K0019228biological_processneuronal action potential
K0045202cellular_componentsynapse
K0055085biological_processtransmembrane transport
L0005243molecular_functiongap junction channel activity
L0005886cellular_componentplasma membrane
L0005921cellular_componentgap junction
L0005922cellular_componentconnexin complex
L0007154biological_processcell communication
L0007267biological_processcell-cell signaling
L0007268biological_processchemical synaptic transmission
L0007601biological_processvisual perception
L0019228biological_processneuronal action potential
L0045202cellular_componentsynapse
L0055085biological_processtransmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CNTlQPGCnqACYD
ChainResidueDetails
ACYS55-ASP68

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Cnry.PCikeVECYVSRP
ChainResidueDetails
ACYS231-PRO247

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1056
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATHR20-GLY42
CILE76-VAL98
CPHE198-LEU220
CPHE253-LEU275
DTHR20-GLY42
DILE76-VAL98
DPHE198-LEU220
DPHE253-LEU275
ETHR20-GLY42
EILE76-VAL98
EPHE198-LEU220
AILE76-VAL98
EPHE253-LEU275
FTHR20-GLY42
FILE76-VAL98
FPHE198-LEU220
FPHE253-LEU275
GTHR20-GLY42
GILE76-VAL98
GPHE198-LEU220
GPHE253-LEU275
HTHR20-GLY42
APHE198-LEU220
HILE76-VAL98
HPHE198-LEU220
HPHE253-LEU275
ITHR20-GLY42
IILE76-VAL98
IPHE198-LEU220
IPHE253-LEU275
JTHR20-GLY42
JILE76-VAL98
JPHE198-LEU220
APHE253-LEU275
JPHE253-LEU275
KTHR20-GLY42
KILE76-VAL98
KPHE198-LEU220
KPHE253-LEU275
LTHR20-GLY42
LILE76-VAL98
LPHE198-LEU220
LPHE253-LEU275
BTHR20-GLY42
BILE76-VAL98
BPHE198-LEU220
BPHE253-LEU275
CTHR20-GLY42

site_idSWS_FT_FI2
Number of Residues756
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLU43-HIS75
ETYR221-VAL252
FGLU43-HIS75
FTYR221-VAL252
GGLU43-HIS75
GTYR221-VAL252
HGLU43-HIS75
HTYR221-VAL252
IGLU43-HIS75
ITYR221-VAL252
JGLU43-HIS75
ATYR221-VAL252
JTYR221-VAL252
KGLU43-HIS75
KTYR221-VAL252
LGLU43-HIS75
LTYR221-VAL252
BGLU43-HIS75
BTYR221-VAL252
CGLU43-HIS75
CTYR221-VAL252
DGLU43-HIS75
DTYR221-VAL252
EGLU43-HIS75

site_idSWS_FT_FI3
Number of Residues1716
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AHIS99-ARG197
EGLY276-VAL321
FHIS99-ARG197
FGLY276-VAL321
GHIS99-ARG197
GGLY276-VAL321
HHIS99-ARG197
HGLY276-VAL321
IHIS99-ARG197
IGLY276-VAL321
JHIS99-ARG197
AGLY276-VAL321
JGLY276-VAL321
KHIS99-ARG197
KGLY276-VAL321
LHIS99-ARG197
LGLY276-VAL321
BHIS99-ARG197
BGLY276-VAL321
CHIS99-ARG197
CGLY276-VAL321
DHIS99-ARG197
DGLY276-VAL321
EHIS99-ARG197

227344

PDB entries from 2024-11-13

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