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7XL6

Cryo-EM structure of human pannexin 3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001649biological_processosteoblast differentiation
A0005198molecular_functionstructural molecule activity
A0005262molecular_functioncalcium channel activity
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0006812biological_processmonoatomic cation transport
A0007267biological_processcell-cell signaling
A0015267molecular_functionchannel activity
A0022829molecular_functionwide pore channel activity
A0032732biological_processpositive regulation of interleukin-1 production
A0034220biological_processmonoatomic ion transmembrane transport
A0055077molecular_functiongap junction hemi-channel activity
A0070588biological_processcalcium ion transmembrane transport
B0001649biological_processosteoblast differentiation
B0005198molecular_functionstructural molecule activity
B0005262molecular_functioncalcium channel activity
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0006812biological_processmonoatomic cation transport
B0007267biological_processcell-cell signaling
B0015267molecular_functionchannel activity
B0022829molecular_functionwide pore channel activity
B0032732biological_processpositive regulation of interleukin-1 production
B0034220biological_processmonoatomic ion transmembrane transport
B0055077molecular_functiongap junction hemi-channel activity
B0070588biological_processcalcium ion transmembrane transport
C0001649biological_processosteoblast differentiation
C0005198molecular_functionstructural molecule activity
C0005262molecular_functioncalcium channel activity
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0006812biological_processmonoatomic cation transport
C0007267biological_processcell-cell signaling
C0015267molecular_functionchannel activity
C0022829molecular_functionwide pore channel activity
C0032732biological_processpositive regulation of interleukin-1 production
C0034220biological_processmonoatomic ion transmembrane transport
C0055077molecular_functiongap junction hemi-channel activity
C0070588biological_processcalcium ion transmembrane transport
D0001649biological_processosteoblast differentiation
D0005198molecular_functionstructural molecule activity
D0005262molecular_functioncalcium channel activity
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0006812biological_processmonoatomic cation transport
D0007267biological_processcell-cell signaling
D0015267molecular_functionchannel activity
D0022829molecular_functionwide pore channel activity
D0032732biological_processpositive regulation of interleukin-1 production
D0034220biological_processmonoatomic ion transmembrane transport
D0055077molecular_functiongap junction hemi-channel activity
D0070588biological_processcalcium ion transmembrane transport
E0001649biological_processosteoblast differentiation
E0005198molecular_functionstructural molecule activity
E0005262molecular_functioncalcium channel activity
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0006812biological_processmonoatomic cation transport
E0007267biological_processcell-cell signaling
E0015267molecular_functionchannel activity
E0022829molecular_functionwide pore channel activity
E0032732biological_processpositive regulation of interleukin-1 production
E0034220biological_processmonoatomic ion transmembrane transport
E0055077molecular_functiongap junction hemi-channel activity
E0070588biological_processcalcium ion transmembrane transport
F0001649biological_processosteoblast differentiation
F0005198molecular_functionstructural molecule activity
F0005262molecular_functioncalcium channel activity
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0006812biological_processmonoatomic cation transport
F0007267biological_processcell-cell signaling
F0015267molecular_functionchannel activity
F0022829molecular_functionwide pore channel activity
F0032732biological_processpositive regulation of interleukin-1 production
F0034220biological_processmonoatomic ion transmembrane transport
F0055077molecular_functiongap junction hemi-channel activity
F0070588biological_processcalcium ion transmembrane transport
G0001649biological_processosteoblast differentiation
G0005198molecular_functionstructural molecule activity
G0005262molecular_functioncalcium channel activity
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0006812biological_processmonoatomic cation transport
G0007267biological_processcell-cell signaling
G0015267molecular_functionchannel activity
G0022829molecular_functionwide pore channel activity
G0032732biological_processpositive regulation of interleukin-1 production
G0034220biological_processmonoatomic ion transmembrane transport
G0055077molecular_functiongap junction hemi-channel activity
G0070588biological_processcalcium ion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1547
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
FMET1-LYS39
CMET1-LYS39
CALA135-LEU215
CTYR289-PRO392
DMET1-LYS39
DALA135-LEU215
DTYR289-PRO392
EMET1-LYS39
EALA135-LEU215
ETYR289-PRO392
GMET1-LYS39
FALA135-LEU215
GALA135-LEU215
GTYR289-PRO392
FTYR289-PRO392
AMET1-LYS39
AALA135-LEU215
ATYR289-PRO392
BMET1-LYS39
BALA135-LEU215
BTYR289-PRO392

site_idSWS_FT_FI2
Number of Residues560
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351
ChainResidueDetails
FPHE40-SER60
BLEU114-PRO134
BLEU216-PHE236
BILE268-ILE288
CPHE40-SER60
CLEU114-PRO134
CLEU216-PHE236
CILE268-ILE288
DPHE40-SER60
DLEU114-PRO134
DLEU216-PHE236
FLEU114-PRO134
DILE268-ILE288
EPHE40-SER60
ELEU114-PRO134
ELEU216-PHE236
EILE268-ILE288
GPHE40-SER60
GLEU114-PRO134
GLEU216-PHE236
GILE268-ILE288
FLEU216-PHE236
FILE268-ILE288
APHE40-SER60
ALEU114-PRO134
ALEU216-PHE236
AILE268-ILE288
BPHE40-SER60

site_idSWS_FT_FI3
Number of Residues574
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
FGLY61-SER113
DGLN237-SER267
EGLY61-SER113
EGLN237-SER267
GGLY61-SER113
GGLN237-SER267
FGLN237-SER267
AGLY61-SER113
AGLN237-SER267
BGLY61-SER113
BGLN237-SER267
CGLY61-SER113
CGLN237-SER267
DGLY61-SER113

site_idSWS_FT_FI4
Number of Residues7
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
FASN71
AASN71
BASN71
CASN71
DASN71
EASN71
GASN71

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PDB entries from 2024-07-17

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