7XAY

Crystal structure of Hat1-Hat2-Asf1-H3-H4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0005506	molecular_function	iron ion binding
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
A	0009055	molecular_function	electron transfer activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0042393	molecular_function	histone binding
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
B	0000123	cellular_component	histone acetyltransferase complex
B	0000781	cellular_component	chromosome, telomeric region
B	0004402	molecular_function	histone acetyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0033698	cellular_component	Rpd3L complex
B	0042393	molecular_function	histone binding
B	0070210	cellular_component	Rpd3L-Expanded complex
C	0005634	cellular_component	nucleus
C	0006325	biological_process	chromatin organization
D	0000500	cellular_component	RNA polymerase I upstream activating factor complex
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006878	biological_process	intracellular copper ion homeostasis
D	0008823	molecular_function	cupric reductase activity
D	0009060	biological_process	aerobic respiration
D	0009303	biological_process	rRNA transcription
D	0030527	molecular_function	structural constituent of chromatin
D	0031298	cellular_component	replication fork protection complex
D	0032991	cellular_component	protein-containing complex
D	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
D	0043505	cellular_component	CENP-A containing nucleosome
D	0043935	biological_process	sexual sporulation resulting in formation of a cellular spore
D	0045943	biological_process	positive regulation of transcription by RNA polymerase I
D	0046982	molecular_function	protein heterodimerization activity
D	0070911	biological_process	global genome nucleotide-excision repair
E	0000500	cellular_component	RNA polymerase I upstream activating factor complex
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0006355	biological_process	regulation of DNA-templated transcription
E	0030527	molecular_function	structural constituent of chromatin
E	0031298	cellular_component	replication fork protection complex
E	0032991	cellular_component	protein-containing complex
E	0042790	biological_process	nucleolar large rRNA transcription by RNA polymerase I
E	0045943	biological_process	positive regulation of transcription by RNA polymerase I
E	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
E	GLY14-HIS18

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
D	LYS14-LEU20

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site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
D	PRO66-ILE74

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSGsdDhTVALWEV

Chain	Residue	Details
B	LEU176-VAL190
B	VAL311-LEU325

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
E	LYS16-LYS20
A	ILE6

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:22343720

Chain	Residue	Details
E	LYS8
D	LYS27
E	LYS12

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:11080160, ECO:0000269|PubMed:15150415, ECO:0000269|PubMed:17289592, ECO:0000269|PubMed:19113941

Chain	Residue	Details
A	GLN227
A	ASN258
E	LYS16

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:22389435

Chain	Residue	Details
E	LYS77
E	LYS31

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269|PubMed:19113941

Chain	Residue	Details
E	ARG55
D	LYS56

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
E	SER60

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:19779198

Chain	Residue	Details
E	SER64

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16768447

Chain	Residue	Details
E	LYS79

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site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine => ECO:0000269|PubMed:31542297

Chain	Residue	Details
E	LYS91

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 224

Chain	Residue	Details
A	PHE220	electrostatic stabiliser, hydrogen bond donor
A	GLU255	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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