Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7X76

Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with two Zur dimers

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0016779	molecular_function	nucleotidyltransferase activity
A	0046983	molecular_function	protein dimerization activity
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005737	cellular_component	cytoplasm
B	0006351	biological_process	DNA-templated transcription
B	0016779	molecular_function	nucleotidyltransferase activity
B	0046983	molecular_function	protein dimerization activity
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0016779	molecular_function	nucleotidyltransferase activity
C	0032549	molecular_function	ribonucleoside binding
C	0034062	molecular_function	5'-3' RNA polymerase activity
D	0000287	molecular_function	magnesium ion binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0003677	molecular_function	DNA binding
D	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
D	0006351	biological_process	DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0016779	molecular_function	nucleotidyltransferase activity
D	0034062	molecular_function	5'-3' RNA polymerase activity
D	0046872	molecular_function	metal ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034062	molecular_function	5'-3' RNA polymerase activity
F	0001108	molecular_function	bacterial-type RNA polymerase holo enzyme binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006352	biological_process	DNA-templated transcription initiation
F	0006355	biological_process	regulation of DNA-templated transcription
F	0010468	biological_process	regulation of gene expression
F	0016987	molecular_function	sigma factor activity
F	2000142	biological_process	regulation of DNA-templated transcription initiation
G	0000976	molecular_function	transcription cis-regulatory region binding
G	0001217	molecular_function	DNA-binding transcription repressor activity
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008270	molecular_function	zinc ion binding
G	0032993	cellular_component	protein-DNA complex
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046872	molecular_function	metal ion binding
G	1900376	biological_process	regulation of secondary metabolite biosynthetic process
H	0000976	molecular_function	transcription cis-regulatory region binding
H	0001217	molecular_function	DNA-binding transcription repressor activity
H	0003700	molecular_function	DNA-binding transcription factor activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008270	molecular_function	zinc ion binding
H	0032993	cellular_component	protein-DNA complex
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0046872	molecular_function	metal ion binding
H	1900376	biological_process	regulation of secondary metabolite biosynthetic process
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0001217	molecular_function	DNA-binding transcription repressor activity
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006355	biological_process	regulation of DNA-templated transcription
M	0008270	molecular_function	zinc ion binding
M	0032993	cellular_component	protein-DNA complex
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0046872	molecular_function	metal ion binding
M	1900376	biological_process	regulation of secondary metabolite biosynthetic process
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0001217	molecular_function	DNA-binding transcription repressor activity
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006355	biological_process	regulation of DNA-templated transcription
N	0008270	molecular_function	zinc ion binding
N	0032993	cellular_component	protein-DNA complex
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0046872	molecular_function	metal ion binding
N	1900376	biological_process	regulation of secondary metabolite biosynthetic process
S	0000428	cellular_component	DNA-directed RNA polymerase complex
S	0003677	molecular_function	DNA binding
S	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
S	0005737	cellular_component	cytoplasm
S	0006351	biological_process	DNA-templated transcription
S	0016779	molecular_function	nucleotidyltransferase activity
S	0046983	molecular_function	protein dimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00715
Number of Residues	14
Details	SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnLGLIrAV

Chain	Residue	Details
F	ASP302-VAL315

site_id	PS00716
Number of Residues	27
Details	SIGMA70_2 Sigma-70 factors family signature 2. TldEIGkvygVTrerIrQIEsktMskL

Chain	Residue	Details
F	THR471-LEU497

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANLRL

Chain	Residue	Details
F	LEU278-LEU285

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKLAGrHGNKGV

Chain	Residue	Details
C	GLY868-VAL880

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255\|HAMAP-Rule:MF_00963

Chain	Residue	Details
F	LEU472-SER491
D	CYS969
D	CYS972
D	CYS62
D	CYS75
D	CYS78
D	ASP535
D	ASP537
D	ASP539
D	CYS886
D	CYS962

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)