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7X1J

Cryo-EM structure of human BTR1 in the outward-facing state in the presence of NH4Cl.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005272molecular_functionsodium channel activity
A0005372molecular_functionwater transmembrane transporter activity
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006814biological_processsodium ion transport
A0006820biological_processmonoatomic anion transport
A0006833biological_processwater transport
A0012506cellular_componentvesicle membrane
A0015078molecular_functionproton transmembrane transporter activity
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015252molecular_functionproton channel activity
A0015293molecular_functionsymporter activity
A0015297molecular_functionantiporter activity
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0022857molecular_functiontransmembrane transporter activity
A0030003biological_processintracellular monoatomic cation homeostasis
A0034599biological_processcellular response to oxidative stress
A0035445biological_processborate transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0042044biological_processfluid transport
A0046713biological_processborate transport
A0046715molecular_functionactive borate transmembrane transporter activity
A0046983molecular_functionprotein dimerization activity
A0050801biological_processmonoatomic ion homeostasis
A0051881biological_processregulation of mitochondrial membrane potential
A0055085biological_processtransmembrane transport
A0071476biological_processcellular hypotonic response
A1902600biological_processproton transmembrane transport
A2000739biological_processregulation of mesenchymal stem cell differentiation
B0005272molecular_functionsodium channel activity
B0005372molecular_functionwater transmembrane transporter activity
B0005452molecular_functionsolute:inorganic anion antiporter activity
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006814biological_processsodium ion transport
B0006820biological_processmonoatomic anion transport
B0006833biological_processwater transport
B0012506cellular_componentvesicle membrane
B0015078molecular_functionproton transmembrane transporter activity
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015252molecular_functionproton channel activity
B0015293molecular_functionsymporter activity
B0015297molecular_functionantiporter activity
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0022857molecular_functiontransmembrane transporter activity
B0030003biological_processintracellular monoatomic cation homeostasis
B0034599biological_processcellular response to oxidative stress
B0035445biological_processborate transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0042044biological_processfluid transport
B0046713biological_processborate transport
B0046715molecular_functionactive borate transmembrane transporter activity
B0046983molecular_functionprotein dimerization activity
B0050801biological_processmonoatomic ion homeostasis
B0051881biological_processregulation of mitochondrial membrane potential
B0055085biological_processtransmembrane transport
B0071476biological_processcellular hypotonic response
B1902600biological_processproton transmembrane transport
B2000739biological_processregulation of mesenchymal stem cell differentiation
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues860
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:21288032
ChainResidueDetails
BMET1-PRO358
ASER425-LEU429
ASER484-GLU491
APHE594-GLU606
AGLU675-ASP699
ALEU776-LYS781
AARG827-TYR831
APRO874-PRO891
BSER425-LEU429
BSER484-GLU491
BPHE594-GLU606
BGLU675-ASP699
BLEU776-LYS781
BARG827-TYR831
BPRO874-PRO891
AMET1-PRO358

site_idSWS_FT_FI2
Number of Residues544
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BTYR375-ASN397
BVAL751-PRO775
BPRO782-ASN799
BARG804-GLN826
BPHE832-MET848
BTYR853-LEU873
ATYR375-ASN397
AILE411-PHE424
AVAL430-ARG446
ATYR460-MET483
AGLU492-LYS512
BILE411-PHE424
AALA572-GLN593
AILE607-PHE628
AALA657-ILE674
ALEU700-ALA720
AVAL751-PRO775
APRO782-ASN799
AARG804-GLN826
APHE832-MET848
ATYR853-LEU873
BVAL430-ARG446
BTYR460-MET483
BGLU492-LYS512
BALA572-GLN593
BILE607-PHE628
BALA657-ILE674
BLEU700-ALA720

site_idSWS_FT_FI3
Number of Residues288
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:21288032
ChainResidueDetails
BASP398-THR410
AILE513-GLN571
AARG629-ARG656
AALA721-ASN750
AGLN800-GLN803
ASER849-PRO852
BVAL447-PHE459
BILE513-GLN571
BARG629-ARG656
BALA721-ASN750
BGLN800-GLN803
BSER849-PRO852
AASP398-THR410
AVAL447-PHE459

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN545
BASN553
AASN545
AASN553

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PDB entries from 2024-11-13

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