7WZ8

Structure of human langerin complex in Birbeck granules

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0005515	molecular_function	protein binding
A	0005537	molecular_function	D-mannose binding
A	0005886	cellular_component	plasma membrane
A	0006281	biological_process	DNA repair
A	0006955	biological_process	immune response
A	0009897	cellular_component	external side of plasma membrane
A	0016020	cellular_component	membrane
A	0030139	cellular_component	endocytic vesicle
A	0030246	molecular_function	carbohydrate binding
A	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
A	0031901	cellular_component	early endosome membrane
A	0038187	molecular_function	pattern recognition receptor activity
A	0051607	biological_process	defense response to virus
B	0003824	molecular_function	catalytic activity
B	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0005537	molecular_function	D-mannose binding
B	0005886	cellular_component	plasma membrane
B	0006281	biological_process	DNA repair
B	0006955	biological_process	immune response
B	0009897	cellular_component	external side of plasma membrane
B	0016020	cellular_component	membrane
B	0030139	cellular_component	endocytic vesicle
B	0030246	molecular_function	carbohydrate binding
B	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0038187	molecular_function	pattern recognition receptor activity
B	0051607	biological_process	defense response to virus
C	0003824	molecular_function	catalytic activity
C	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
C	0005515	molecular_function	protein binding
C	0005537	molecular_function	D-mannose binding
C	0005886	cellular_component	plasma membrane
C	0006281	biological_process	DNA repair
C	0006955	biological_process	immune response
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0030139	cellular_component	endocytic vesicle
C	0030246	molecular_function	carbohydrate binding
C	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
C	0031901	cellular_component	early endosome membrane
C	0038187	molecular_function	pattern recognition receptor activity
C	0051607	biological_process	defense response to virus
D	0003824	molecular_function	catalytic activity
D	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
D	0005515	molecular_function	protein binding
D	0005537	molecular_function	D-mannose binding
D	0005886	cellular_component	plasma membrane
D	0006281	biological_process	DNA repair
D	0006955	biological_process	immune response
D	0009897	cellular_component	external side of plasma membrane
D	0016020	cellular_component	membrane
D	0030139	cellular_component	endocytic vesicle
D	0030246	molecular_function	carbohydrate binding
D	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0038187	molecular_function	pattern recognition receptor activity
D	0051607	biological_process	defense response to virus
E	0003824	molecular_function	catalytic activity
E	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
E	0005515	molecular_function	protein binding
E	0005537	molecular_function	D-mannose binding
E	0005886	cellular_component	plasma membrane
E	0006281	biological_process	DNA repair
E	0006955	biological_process	immune response
E	0009897	cellular_component	external side of plasma membrane
E	0016020	cellular_component	membrane
E	0030139	cellular_component	endocytic vesicle
E	0030246	molecular_function	carbohydrate binding
E	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0038187	molecular_function	pattern recognition receptor activity
E	0051607	biological_process	defense response to virus
F	0003824	molecular_function	catalytic activity
F	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
F	0005515	molecular_function	protein binding
F	0005537	molecular_function	D-mannose binding
F	0005886	cellular_component	plasma membrane
F	0006281	biological_process	DNA repair
F	0006955	biological_process	immune response
F	0009897	cellular_component	external side of plasma membrane
F	0016020	cellular_component	membrane
F	0030139	cellular_component	endocytic vesicle
F	0030246	molecular_function	carbohydrate binding
F	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0038187	molecular_function	pattern recognition receptor activity
F	0051607	biological_process	defense response to virus

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
C	ILE-80-VAL-74

---

site_id	PS00615
Number of Residues	25
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CGnikapslqa...WNDAPCdktfl.FIC

Chain	Residue	Details
C	CYS295-CYS319

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG

Chain	Residue	Details
C	GLY-196-GLY-186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	708
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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