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7WVX

Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001973biological_processG protein-coupled adenosine receptor signaling pathway
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007584biological_processresponse to nutrient
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032930biological_processpositive regulation of superoxide anion generation
A0035810biological_processpositive regulation of urine volume
A0044297cellular_componentcell body
A0045202cellular_componentsynapse
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0051924biological_processregulation of calcium ion transport
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0098992cellular_componentneuronal dense core vesicle
A0140199biological_processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
A1903561cellular_componentextracellular vesicle
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2000179biological_processpositive regulation of neural precursor cell proliferation
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
L0001664molecular_functionG protein-coupled receptor binding
L0005102molecular_functionsignaling receptor binding
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0006879biological_processintracellular iron ion homeostasis
L0006915biological_processapoptotic process
L0007005biological_processmitochondrion organization
L0007267biological_processcell-cell signaling
L0030595biological_processleukocyte chemotaxis
L0031514cellular_componentmotile cilium
L0032692biological_processnegative regulation of interleukin-1 production
L0032701biological_processnegative regulation of interleukin-18 production
L0036126cellular_componentsperm flagellum
L0042802molecular_functionidentical protein binding
L0043066biological_processnegative regulation of apoptotic process
L0043524biological_processnegative regulation of neuron apoptotic process
L0048019molecular_functionreceptor antagonist activity
L0048471cellular_componentperinuclear region of cytoplasm
L0050728biological_processnegative regulation of inflammatory response
L0097225cellular_componentsperm midpiece
L0097435biological_processsupramolecular fiber organization
L0150079biological_processnegative regulation of neuroinflammatory response
L1900118biological_processnegative regulation of execution phase of apoptosis
L1900226biological_processnegative regulation of NLRP3 inflammasome complex assembly
L1902883biological_processnegative regulation of response to oxidative stress
L1904646biological_processcellular response to amyloid-beta
L1905907biological_processnegative regulation of amyloid fibril formation
R0001540molecular_functionamyloid-beta binding
R0001774biological_processmicroglial cell activation
R0002430biological_processcomplement receptor mediated signaling pathway
R0002768biological_processimmune response-regulating cell surface receptor signaling pathway
R0004875molecular_functioncomplement receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004982molecular_functionN-formyl peptide receptor activity
R0005124molecular_functionscavenger receptor binding
R0005506molecular_functioniron ion binding
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005886cellular_componentplasma membrane
R0006898biological_processreceptor-mediated endocytosis
R0006935biological_processchemotaxis
R0006954biological_processinflammatory response
R0007155biological_processcell adhesion
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0009055molecular_functionelectron transfer activity
R0016020cellular_componentmembrane
R0019722biological_processcalcium-mediated signaling
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0032930biological_processpositive regulation of superoxide anion generation
R0035579cellular_componentspecific granule membrane
R0038023molecular_functionsignaling receptor activity
R0038024molecular_functioncargo receptor activity
R0042597cellular_componentperiplasmic space
R0042742biological_processdefense response to bacterium
R0045089biological_processpositive regulation of innate immune response
R0046872molecular_functionmetal ion binding
R0048143biological_processastrocyte activation
R0050728biological_processnegative regulation of inflammatory response
R0050766biological_processpositive regulation of phagocytosis
R0050918biological_processpositive chemotaxis
R0061903biological_processobsolete positive regulation of 1-phosphatidylinositol-3-kinase activity
R0070374biological_processpositive regulation of ERK1 and ERK2 cascade
R0070821cellular_componenttertiary granule membrane
R0090026biological_processpositive regulation of monocyte chemotaxis
R0101003cellular_componentficolin-1-rich granule membrane
R1904646biological_processcellular response to amyloid-beta
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. GSVfLIGFIALDRCIcV
ChainResidueDetails
RGLY111-VAL127

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
CALA2
AASP201
AASN270

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
ALEU176
ATHR182
ASER327

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
CCYS68
RASP122-SER140
RLYS227-VAL242

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
AGLN205

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
ACYS352
RPHE163-ARG205
RTRP267-PRO286

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:22223895, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
AGLY2

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS3

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RPHE206-ALA226

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RLEU243-VAL266

site_idSWS_FT_FI10
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RTHR287-GLY306

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN4

219140

PDB entries from 2024-05-01

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