7WUB

Cryo-EM structure of dodecamer P97

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0003689	molecular_function	DNA clamp loader activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006302	biological_process	double-strand break repair
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006734	biological_process	NADH metabolic process
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006914	biological_process	autophagy
A	0006974	biological_process	DNA damage response
A	0008289	molecular_function	lipid binding
A	0010494	cellular_component	cytoplasmic stress granule
A	0010498	biological_process	proteasomal protein catabolic process
A	0010918	biological_process	positive regulation of mitochondrial membrane potential
A	0016236	biological_process	macroautophagy
A	0016567	biological_process	protein ubiquitination
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019079	biological_process	viral genome replication
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0019985	biological_process	translesion synthesis
A	0030968	biological_process	endoplasmic reticulum unfolded protein response
A	0030970	biological_process	retrograde protein transport, ER to cytosol
A	0031334	biological_process	positive regulation of protein-containing complex assembly
A	0031593	molecular_function	polyubiquitin modification-dependent protein binding
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
A	0032991	cellular_component	protein-containing complex
A	0033554	biological_process	cellular response to stress
A	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
A	0034605	biological_process	cellular response to heat
A	0034774	cellular_component	secretory granule lumen
A	0035331	biological_process	negative regulation of hippo signaling
A	0035578	cellular_component	azurophil granule lumen
A	0035617	biological_process	stress granule disassembly
A	0035800	molecular_function	deubiquitinase activator activity
A	0035861	cellular_component	site of double-strand break
A	0036297	biological_process	interstrand cross-link repair
A	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
A	0036503	biological_process	ERAD pathway
A	0036513	cellular_component	Derlin-1 retrotranslocation complex
A	0042288	molecular_function	MHC class I protein binding
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043531	molecular_function	ADP binding
A	0044389	molecular_function	ubiquitin-like protein ligase binding
A	0044877	molecular_function	protein-containing complex binding
A	0045184	biological_process	establishment of protein localization
A	0045202	cellular_component	synapse
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0046034	biological_process	ATP metabolic process
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050807	biological_process	regulation of synapse organization
A	0051228	biological_process	mitotic spindle disassembly
A	0061775	molecular_function	cohesin loader activity
A	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
A	0070062	cellular_component	extracellular exosome
A	0070842	biological_process	aggresome assembly
A	0071218	biological_process	cellular response to misfolded protein
A	0072389	biological_process	flavin adenine dinucleotide catabolic process
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0097352	biological_process	autophagosome maturation
A	0098978	cellular_component	glutamatergic synapse
A	0106300	biological_process	protein-DNA covalent cross-linking repair
A	0120186	biological_process	negative regulation of protein localization to chromatin
A	0140036	molecular_function	ubiquitin-modified protein reader activity
A	0140455	biological_process	cytoplasm protein quality control
A	0140584	molecular_function	chromatin extrusion motor activity
A	0140588	biological_process	chromatin looping
A	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
A	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
A	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
A	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
A	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
A	1903715	biological_process	regulation of aerobic respiration
A	1903843	biological_process	cellular response to arsenite ion
A	1903862	biological_process	positive regulation of oxidative phosphorylation
A	1904288	molecular_function	BAT3 complex binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1904949	cellular_component	ATPase complex
A	1905634	biological_process	regulation of protein localization to chromatin
A	1990381	molecular_function	ubiquitin-specific protease binding
A	1990730	cellular_component	VCP-NSFL1C complex
A	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
A	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
A	2001171	biological_process	positive regulation of ATP biosynthetic process
B	0000502	cellular_component	proteasome complex
B	0003689	molecular_function	DNA clamp loader activity
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006338	biological_process	chromatin remodeling
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006734	biological_process	NADH metabolic process
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006914	biological_process	autophagy
B	0006974	biological_process	DNA damage response
B	0008289	molecular_function	lipid binding
B	0010494	cellular_component	cytoplasmic stress granule
B	0010498	biological_process	proteasomal protein catabolic process
B	0010918	biological_process	positive regulation of mitochondrial membrane potential
B	0016236	biological_process	macroautophagy
B	0016567	biological_process	protein ubiquitination
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019079	biological_process	viral genome replication
B	0019903	molecular_function	protein phosphatase binding
B	0019904	molecular_function	protein domain specific binding
B	0019985	biological_process	translesion synthesis
B	0030968	biological_process	endoplasmic reticulum unfolded protein response
B	0030970	biological_process	retrograde protein transport, ER to cytosol
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031593	molecular_function	polyubiquitin modification-dependent protein binding
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
B	0032991	cellular_component	protein-containing complex
B	0033554	biological_process	cellular response to stress
B	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
B	0034605	biological_process	cellular response to heat
B	0034774	cellular_component	secretory granule lumen
B	0035331	biological_process	negative regulation of hippo signaling
B	0035578	cellular_component	azurophil granule lumen
B	0035617	biological_process	stress granule disassembly
B	0035800	molecular_function	deubiquitinase activator activity
B	0035861	cellular_component	site of double-strand break
B	0036297	biological_process	interstrand cross-link repair
B	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
B	0036503	biological_process	ERAD pathway
B	0036513	cellular_component	Derlin-1 retrotranslocation complex
B	0042288	molecular_function	MHC class I protein binding
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043531	molecular_function	ADP binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0044877	molecular_function	protein-containing complex binding
B	0045184	biological_process	establishment of protein localization
B	0045202	cellular_component	synapse
B	0045732	biological_process	positive regulation of protein catabolic process
B	0045879	biological_process	negative regulation of smoothened signaling pathway
B	0046034	biological_process	ATP metabolic process
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050807	biological_process	regulation of synapse organization
B	0051228	biological_process	mitotic spindle disassembly
B	0061775	molecular_function	cohesin loader activity
B	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
B	0070062	cellular_component	extracellular exosome
B	0070842	biological_process	aggresome assembly
B	0071218	biological_process	cellular response to misfolded protein
B	0072389	biological_process	flavin adenine dinucleotide catabolic process
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0097352	biological_process	autophagosome maturation
B	0098978	cellular_component	glutamatergic synapse
B	0106300	biological_process	protein-DNA covalent cross-linking repair
B	0120186	biological_process	negative regulation of protein localization to chromatin
B	0140036	molecular_function	ubiquitin-modified protein reader activity
B	0140455	biological_process	cytoplasm protein quality control
B	0140584	molecular_function	chromatin extrusion motor activity
B	0140588	biological_process	chromatin looping
B	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
B	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
B	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
B	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
B	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
B	1903715	biological_process	regulation of aerobic respiration
B	1903843	biological_process	cellular response to arsenite ion
B	1903862	biological_process	positive regulation of oxidative phosphorylation
B	1904288	molecular_function	BAT3 complex binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1904949	cellular_component	ATPase complex
B	1905634	biological_process	regulation of protein localization to chromatin
B	1990381	molecular_function	ubiquitin-specific protease binding
B	1990730	cellular_component	VCP-NSFL1C complex
B	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
B	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
B	2001171	biological_process	positive regulation of ATP biosynthetic process
C	0005524	molecular_function	ATP binding
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
E	0000502	cellular_component	proteasome complex
E	0003689	molecular_function	DNA clamp loader activity
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006302	biological_process	double-strand break repair
E	0006338	biological_process	chromatin remodeling
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006734	biological_process	NADH metabolic process
E	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
E	0006914	biological_process	autophagy
E	0006974	biological_process	DNA damage response
E	0008289	molecular_function	lipid binding
E	0010494	cellular_component	cytoplasmic stress granule
E	0010498	biological_process	proteasomal protein catabolic process
E	0010918	biological_process	positive regulation of mitochondrial membrane potential
E	0016236	biological_process	macroautophagy
E	0016567	biological_process	protein ubiquitination
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019079	biological_process	viral genome replication
E	0019903	molecular_function	protein phosphatase binding
E	0019904	molecular_function	protein domain specific binding
E	0019985	biological_process	translesion synthesis
E	0030968	biological_process	endoplasmic reticulum unfolded protein response
E	0030970	biological_process	retrograde protein transport, ER to cytosol
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031593	molecular_function	polyubiquitin modification-dependent protein binding
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
E	0032991	cellular_component	protein-containing complex
E	0033554	biological_process	cellular response to stress
E	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
E	0034605	biological_process	cellular response to heat
E	0034774	cellular_component	secretory granule lumen
E	0035331	biological_process	negative regulation of hippo signaling
E	0035578	cellular_component	azurophil granule lumen
E	0035617	biological_process	stress granule disassembly
E	0035800	molecular_function	deubiquitinase activator activity
E	0035861	cellular_component	site of double-strand break
E	0036297	biological_process	interstrand cross-link repair
E	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
E	0036503	biological_process	ERAD pathway
E	0036513	cellular_component	Derlin-1 retrotranslocation complex
E	0042288	molecular_function	MHC class I protein binding
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043531	molecular_function	ADP binding
E	0044389	molecular_function	ubiquitin-like protein ligase binding
E	0044877	molecular_function	protein-containing complex binding
E	0045184	biological_process	establishment of protein localization
E	0045202	cellular_component	synapse
E	0045732	biological_process	positive regulation of protein catabolic process
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046034	biological_process	ATP metabolic process
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050807	biological_process	regulation of synapse organization
E	0051228	biological_process	mitotic spindle disassembly
E	0061775	molecular_function	cohesin loader activity
E	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
E	0070062	cellular_component	extracellular exosome
E	0070842	biological_process	aggresome assembly
E	0071218	biological_process	cellular response to misfolded protein
E	0072389	biological_process	flavin adenine dinucleotide catabolic process
E	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
E	0097352	biological_process	autophagosome maturation
E	0098978	cellular_component	glutamatergic synapse
E	0106300	biological_process	protein-DNA covalent cross-linking repair
E	0120186	biological_process	negative regulation of protein localization to chromatin
E	0140036	molecular_function	ubiquitin-modified protein reader activity
E	0140455	biological_process	cytoplasm protein quality control
E	0140584	molecular_function	chromatin extrusion motor activity
E	0140588	biological_process	chromatin looping
E	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
E	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
E	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
E	1903715	biological_process	regulation of aerobic respiration
E	1903843	biological_process	cellular response to arsenite ion
E	1903862	biological_process	positive regulation of oxidative phosphorylation
E	1904288	molecular_function	BAT3 complex binding
E	1904813	cellular_component	ficolin-1-rich granule lumen
E	1904949	cellular_component	ATPase complex
E	1905634	biological_process	regulation of protein localization to chromatin
E	1990381	molecular_function	ubiquitin-specific protease binding
E	1990730	cellular_component	VCP-NSFL1C complex
E	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
E	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
E	2001171	biological_process	positive regulation of ATP biosynthetic process
F	0000502	cellular_component	proteasome complex
F	0003689	molecular_function	DNA clamp loader activity
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005811	cellular_component	lipid droplet
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006302	biological_process	double-strand break repair
F	0006338	biological_process	chromatin remodeling
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006734	biological_process	NADH metabolic process
F	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
F	0006914	biological_process	autophagy
F	0006974	biological_process	DNA damage response
F	0008289	molecular_function	lipid binding
F	0010494	cellular_component	cytoplasmic stress granule
F	0010498	biological_process	proteasomal protein catabolic process
F	0010918	biological_process	positive regulation of mitochondrial membrane potential
F	0016236	biological_process	macroautophagy
F	0016567	biological_process	protein ubiquitination
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019079	biological_process	viral genome replication
F	0019903	molecular_function	protein phosphatase binding
F	0019904	molecular_function	protein domain specific binding
F	0019985	biological_process	translesion synthesis
F	0030968	biological_process	endoplasmic reticulum unfolded protein response
F	0030970	biological_process	retrograde protein transport, ER to cytosol
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031593	molecular_function	polyubiquitin modification-dependent protein binding
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
F	0032991	cellular_component	protein-containing complex
F	0033554	biological_process	cellular response to stress
F	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
F	0034605	biological_process	cellular response to heat
F	0034774	cellular_component	secretory granule lumen
F	0035331	biological_process	negative regulation of hippo signaling
F	0035578	cellular_component	azurophil granule lumen
F	0035617	biological_process	stress granule disassembly
F	0035800	molecular_function	deubiquitinase activator activity
F	0035861	cellular_component	site of double-strand break
F	0036297	biological_process	interstrand cross-link repair
F	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
F	0036503	biological_process	ERAD pathway
F	0036513	cellular_component	Derlin-1 retrotranslocation complex
F	0042288	molecular_function	MHC class I protein binding
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043531	molecular_function	ADP binding
F	0044389	molecular_function	ubiquitin-like protein ligase binding
F	0044877	molecular_function	protein-containing complex binding
F	0045184	biological_process	establishment of protein localization
F	0045202	cellular_component	synapse
F	0045732	biological_process	positive regulation of protein catabolic process
F	0045879	biological_process	negative regulation of smoothened signaling pathway
F	0046034	biological_process	ATP metabolic process
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0050807	biological_process	regulation of synapse organization
F	0051228	biological_process	mitotic spindle disassembly
F	0061775	molecular_function	cohesin loader activity
F	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
F	0070062	cellular_component	extracellular exosome
F	0070842	biological_process	aggresome assembly
F	0071218	biological_process	cellular response to misfolded protein
F	0072389	biological_process	flavin adenine dinucleotide catabolic process
F	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
F	0097352	biological_process	autophagosome maturation
F	0098978	cellular_component	glutamatergic synapse
F	0106300	biological_process	protein-DNA covalent cross-linking repair
F	0120186	biological_process	negative regulation of protein localization to chromatin
F	0140036	molecular_function	ubiquitin-modified protein reader activity
F	0140455	biological_process	cytoplasm protein quality control
F	0140584	molecular_function	chromatin extrusion motor activity
F	0140588	biological_process	chromatin looping
F	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
F	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
F	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
F	1903715	biological_process	regulation of aerobic respiration
F	1903843	biological_process	cellular response to arsenite ion
F	1903862	biological_process	positive regulation of oxidative phosphorylation
F	1904288	molecular_function	BAT3 complex binding
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	1904949	cellular_component	ATPase complex
F	1905634	biological_process	regulation of protein localization to chromatin
F	1990381	molecular_function	ubiquitin-specific protease binding
F	1990730	cellular_component	VCP-NSFL1C complex
F	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
F	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
F	2001171	biological_process	positive regulation of ATP biosynthetic process
G	0000502	cellular_component	proteasome complex
G	0003689	molecular_function	DNA clamp loader activity
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006302	biological_process	double-strand break repair
G	0006338	biological_process	chromatin remodeling
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006734	biological_process	NADH metabolic process
G	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
G	0006914	biological_process	autophagy
G	0006974	biological_process	DNA damage response
G	0008289	molecular_function	lipid binding
G	0010494	cellular_component	cytoplasmic stress granule
G	0010498	biological_process	proteasomal protein catabolic process
G	0010918	biological_process	positive regulation of mitochondrial membrane potential
G	0016236	biological_process	macroautophagy
G	0016567	biological_process	protein ubiquitination
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0019079	biological_process	viral genome replication
G	0019903	molecular_function	protein phosphatase binding
G	0019904	molecular_function	protein domain specific binding
G	0019985	biological_process	translesion synthesis
G	0030968	biological_process	endoplasmic reticulum unfolded protein response
G	0030970	biological_process	retrograde protein transport, ER to cytosol
G	0031334	biological_process	positive regulation of protein-containing complex assembly
G	0031593	molecular_function	polyubiquitin modification-dependent protein binding
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
G	0032991	cellular_component	protein-containing complex
G	0033554	biological_process	cellular response to stress
G	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
G	0034605	biological_process	cellular response to heat
G	0034774	cellular_component	secretory granule lumen
G	0035331	biological_process	negative regulation of hippo signaling
G	0035578	cellular_component	azurophil granule lumen
G	0035617	biological_process	stress granule disassembly
G	0035800	molecular_function	deubiquitinase activator activity
G	0035861	cellular_component	site of double-strand break
G	0036297	biological_process	interstrand cross-link repair
G	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
G	0036503	biological_process	ERAD pathway
G	0036513	cellular_component	Derlin-1 retrotranslocation complex
G	0042288	molecular_function	MHC class I protein binding
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0043531	molecular_function	ADP binding
G	0044389	molecular_function	ubiquitin-like protein ligase binding
G	0044877	molecular_function	protein-containing complex binding
G	0045184	biological_process	establishment of protein localization
G	0045202	cellular_component	synapse
G	0045732	biological_process	positive regulation of protein catabolic process
G	0045879	biological_process	negative regulation of smoothened signaling pathway
G	0046034	biological_process	ATP metabolic process
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050807	biological_process	regulation of synapse organization
G	0051228	biological_process	mitotic spindle disassembly
G	0061775	molecular_function	cohesin loader activity
G	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
G	0070062	cellular_component	extracellular exosome
G	0070842	biological_process	aggresome assembly
G	0071218	biological_process	cellular response to misfolded protein
G	0072389	biological_process	flavin adenine dinucleotide catabolic process
G	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
G	0097352	biological_process	autophagosome maturation
G	0098978	cellular_component	glutamatergic synapse
G	0106300	biological_process	protein-DNA covalent cross-linking repair
G	0120186	biological_process	negative regulation of protein localization to chromatin
G	0140036	molecular_function	ubiquitin-modified protein reader activity
G	0140455	biological_process	cytoplasm protein quality control
G	0140584	molecular_function	chromatin extrusion motor activity
G	0140588	biological_process	chromatin looping
G	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
G	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
G	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
G	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
G	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
G	1903715	biological_process	regulation of aerobic respiration
G	1903843	biological_process	cellular response to arsenite ion
G	1903862	biological_process	positive regulation of oxidative phosphorylation
G	1904288	molecular_function	BAT3 complex binding
G	1904813	cellular_component	ficolin-1-rich granule lumen
G	1904949	cellular_component	ATPase complex
G	1905634	biological_process	regulation of protein localization to chromatin
G	1990381	molecular_function	ubiquitin-specific protease binding
G	1990730	cellular_component	VCP-NSFL1C complex
G	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
G	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
G	2001171	biological_process	positive regulation of ATP biosynthetic process
H	0000502	cellular_component	proteasome complex
H	0003689	molecular_function	DNA clamp loader activity
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006302	biological_process	double-strand break repair
H	0006338	biological_process	chromatin remodeling
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006734	biological_process	NADH metabolic process
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0006914	biological_process	autophagy
H	0006974	biological_process	DNA damage response
H	0008289	molecular_function	lipid binding
H	0010494	cellular_component	cytoplasmic stress granule
H	0010498	biological_process	proteasomal protein catabolic process
H	0010918	biological_process	positive regulation of mitochondrial membrane potential
H	0016236	biological_process	macroautophagy
H	0016567	biological_process	protein ubiquitination
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019079	biological_process	viral genome replication
H	0019903	molecular_function	protein phosphatase binding
H	0019904	molecular_function	protein domain specific binding
H	0019985	biological_process	translesion synthesis
H	0030968	biological_process	endoplasmic reticulum unfolded protein response
H	0030970	biological_process	retrograde protein transport, ER to cytosol
H	0031334	biological_process	positive regulation of protein-containing complex assembly
H	0031593	molecular_function	polyubiquitin modification-dependent protein binding
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
H	0032991	cellular_component	protein-containing complex
H	0033554	biological_process	cellular response to stress
H	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
H	0034605	biological_process	cellular response to heat
H	0034774	cellular_component	secretory granule lumen
H	0035331	biological_process	negative regulation of hippo signaling
H	0035578	cellular_component	azurophil granule lumen
H	0035617	biological_process	stress granule disassembly
H	0035800	molecular_function	deubiquitinase activator activity
H	0035861	cellular_component	site of double-strand break
H	0036297	biological_process	interstrand cross-link repair
H	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
H	0036503	biological_process	ERAD pathway
H	0036513	cellular_component	Derlin-1 retrotranslocation complex
H	0042288	molecular_function	MHC class I protein binding
H	0042802	molecular_function	identical protein binding
H	0042981	biological_process	regulation of apoptotic process
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0043531	molecular_function	ADP binding
H	0044389	molecular_function	ubiquitin-like protein ligase binding
H	0044877	molecular_function	protein-containing complex binding
H	0045184	biological_process	establishment of protein localization
H	0045202	cellular_component	synapse
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045879	biological_process	negative regulation of smoothened signaling pathway
H	0046034	biological_process	ATP metabolic process
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0050807	biological_process	regulation of synapse organization
H	0051228	biological_process	mitotic spindle disassembly
H	0061775	molecular_function	cohesin loader activity
H	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
H	0070062	cellular_component	extracellular exosome
H	0070842	biological_process	aggresome assembly
H	0071218	biological_process	cellular response to misfolded protein
H	0072389	biological_process	flavin adenine dinucleotide catabolic process
H	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
H	0097352	biological_process	autophagosome maturation
H	0098978	cellular_component	glutamatergic synapse
H	0106300	biological_process	protein-DNA covalent cross-linking repair
H	0120186	biological_process	negative regulation of protein localization to chromatin
H	0140036	molecular_function	ubiquitin-modified protein reader activity
H	0140455	biological_process	cytoplasm protein quality control
H	0140584	molecular_function	chromatin extrusion motor activity
H	0140588	biological_process	chromatin looping
H	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
H	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
H	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
H	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
H	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
H	1903715	biological_process	regulation of aerobic respiration
H	1903843	biological_process	cellular response to arsenite ion
H	1903862	biological_process	positive regulation of oxidative phosphorylation
H	1904288	molecular_function	BAT3 complex binding
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	1904949	cellular_component	ATPase complex
H	1905634	biological_process	regulation of protein localization to chromatin
H	1990381	molecular_function	ubiquitin-specific protease binding
H	1990730	cellular_component	VCP-NSFL1C complex
H	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
H	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
H	2001171	biological_process	positive regulation of ATP biosynthetic process
I	0000502	cellular_component	proteasome complex
I	0003689	molecular_function	DNA clamp loader activity
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006302	biological_process	double-strand break repair
I	0006338	biological_process	chromatin remodeling
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006734	biological_process	NADH metabolic process
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006914	biological_process	autophagy
I	0006974	biological_process	DNA damage response
I	0008289	molecular_function	lipid binding
I	0010494	cellular_component	cytoplasmic stress granule
I	0010498	biological_process	proteasomal protein catabolic process
I	0010918	biological_process	positive regulation of mitochondrial membrane potential
I	0016236	biological_process	macroautophagy
I	0016567	biological_process	protein ubiquitination
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0019079	biological_process	viral genome replication
I	0019903	molecular_function	protein phosphatase binding
I	0019904	molecular_function	protein domain specific binding
I	0019985	biological_process	translesion synthesis
I	0030968	biological_process	endoplasmic reticulum unfolded protein response
I	0030970	biological_process	retrograde protein transport, ER to cytosol
I	0031334	biological_process	positive regulation of protein-containing complex assembly
I	0031593	molecular_function	polyubiquitin modification-dependent protein binding
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
I	0032991	cellular_component	protein-containing complex
I	0033554	biological_process	cellular response to stress
I	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
I	0034605	biological_process	cellular response to heat
I	0034774	cellular_component	secretory granule lumen
I	0035331	biological_process	negative regulation of hippo signaling
I	0035578	cellular_component	azurophil granule lumen
I	0035617	biological_process	stress granule disassembly
I	0035800	molecular_function	deubiquitinase activator activity
I	0035861	cellular_component	site of double-strand break
I	0036297	biological_process	interstrand cross-link repair
I	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
I	0036503	biological_process	ERAD pathway
I	0036513	cellular_component	Derlin-1 retrotranslocation complex
I	0042288	molecular_function	MHC class I protein binding
I	0042802	molecular_function	identical protein binding
I	0042981	biological_process	regulation of apoptotic process
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0043531	molecular_function	ADP binding
I	0044389	molecular_function	ubiquitin-like protein ligase binding
I	0044877	molecular_function	protein-containing complex binding
I	0045184	biological_process	establishment of protein localization
I	0045202	cellular_component	synapse
I	0045732	biological_process	positive regulation of protein catabolic process
I	0045879	biological_process	negative regulation of smoothened signaling pathway
I	0046034	biological_process	ATP metabolic process
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0050807	biological_process	regulation of synapse organization
I	0051228	biological_process	mitotic spindle disassembly
I	0061775	molecular_function	cohesin loader activity
I	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
I	0070062	cellular_component	extracellular exosome
I	0070842	biological_process	aggresome assembly
I	0071218	biological_process	cellular response to misfolded protein
I	0072389	biological_process	flavin adenine dinucleotide catabolic process
I	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
I	0097352	biological_process	autophagosome maturation
I	0098978	cellular_component	glutamatergic synapse
I	0106300	biological_process	protein-DNA covalent cross-linking repair
I	0120186	biological_process	negative regulation of protein localization to chromatin
I	0140036	molecular_function	ubiquitin-modified protein reader activity
I	0140455	biological_process	cytoplasm protein quality control
I	0140584	molecular_function	chromatin extrusion motor activity
I	0140588	biological_process	chromatin looping
I	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
I	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
I	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
I	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
I	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
I	1903715	biological_process	regulation of aerobic respiration
I	1903843	biological_process	cellular response to arsenite ion
I	1903862	biological_process	positive regulation of oxidative phosphorylation
I	1904288	molecular_function	BAT3 complex binding
I	1904813	cellular_component	ficolin-1-rich granule lumen
I	1904949	cellular_component	ATPase complex
I	1905634	biological_process	regulation of protein localization to chromatin
I	1990381	molecular_function	ubiquitin-specific protease binding
I	1990730	cellular_component	VCP-NSFL1C complex
I	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
I	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
I	2001171	biological_process	positive regulation of ATP biosynthetic process
J	0000502	cellular_component	proteasome complex
J	0003689	molecular_function	DNA clamp loader activity
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005811	cellular_component	lipid droplet
J	0005829	cellular_component	cytosol
J	0006281	biological_process	DNA repair
J	0006302	biological_process	double-strand break repair
J	0006338	biological_process	chromatin remodeling
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0006734	biological_process	NADH metabolic process
J	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
J	0006914	biological_process	autophagy
J	0006974	biological_process	DNA damage response
J	0008289	molecular_function	lipid binding
J	0010494	cellular_component	cytoplasmic stress granule
J	0010498	biological_process	proteasomal protein catabolic process
J	0010918	biological_process	positive regulation of mitochondrial membrane potential
J	0016236	biological_process	macroautophagy
J	0016567	biological_process	protein ubiquitination
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0019079	biological_process	viral genome replication
J	0019903	molecular_function	protein phosphatase binding
J	0019904	molecular_function	protein domain specific binding
J	0019985	biological_process	translesion synthesis
J	0030968	biological_process	endoplasmic reticulum unfolded protein response
J	0030970	biological_process	retrograde protein transport, ER to cytosol
J	0031334	biological_process	positive regulation of protein-containing complex assembly
J	0031593	molecular_function	polyubiquitin modification-dependent protein binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
J	0032991	cellular_component	protein-containing complex
J	0033554	biological_process	cellular response to stress
J	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
J	0034605	biological_process	cellular response to heat
J	0034774	cellular_component	secretory granule lumen
J	0035331	biological_process	negative regulation of hippo signaling
J	0035578	cellular_component	azurophil granule lumen
J	0035617	biological_process	stress granule disassembly
J	0035800	molecular_function	deubiquitinase activator activity
J	0035861	cellular_component	site of double-strand break
J	0036297	biological_process	interstrand cross-link repair
J	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
J	0036503	biological_process	ERAD pathway
J	0036513	cellular_component	Derlin-1 retrotranslocation complex
J	0042288	molecular_function	MHC class I protein binding
J	0042802	molecular_function	identical protein binding
J	0042981	biological_process	regulation of apoptotic process
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0043531	molecular_function	ADP binding
J	0044389	molecular_function	ubiquitin-like protein ligase binding
J	0044877	molecular_function	protein-containing complex binding
J	0045184	biological_process	establishment of protein localization
J	0045202	cellular_component	synapse
J	0045732	biological_process	positive regulation of protein catabolic process
J	0045879	biological_process	negative regulation of smoothened signaling pathway
J	0046034	biological_process	ATP metabolic process
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0050807	biological_process	regulation of synapse organization
J	0051228	biological_process	mitotic spindle disassembly
J	0061775	molecular_function	cohesin loader activity
J	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
J	0070062	cellular_component	extracellular exosome
J	0070842	biological_process	aggresome assembly
J	0071218	biological_process	cellular response to misfolded protein
J	0072389	biological_process	flavin adenine dinucleotide catabolic process
J	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
J	0097352	biological_process	autophagosome maturation
J	0098978	cellular_component	glutamatergic synapse
J	0106300	biological_process	protein-DNA covalent cross-linking repair
J	0120186	biological_process	negative regulation of protein localization to chromatin
J	0140036	molecular_function	ubiquitin-modified protein reader activity
J	0140455	biological_process	cytoplasm protein quality control
J	0140584	molecular_function	chromatin extrusion motor activity
J	0140588	biological_process	chromatin looping
J	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
J	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
J	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
J	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
J	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
J	1903715	biological_process	regulation of aerobic respiration
J	1903843	biological_process	cellular response to arsenite ion
J	1903862	biological_process	positive regulation of oxidative phosphorylation
J	1904288	molecular_function	BAT3 complex binding
J	1904813	cellular_component	ficolin-1-rich granule lumen
J	1904949	cellular_component	ATPase complex
J	1905634	biological_process	regulation of protein localization to chromatin
J	1990381	molecular_function	ubiquitin-specific protease binding
J	1990730	cellular_component	VCP-NSFL1C complex
J	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
J	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
J	2001171	biological_process	positive regulation of ATP biosynthetic process
K	0000502	cellular_component	proteasome complex
K	0003689	molecular_function	DNA clamp loader activity
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005811	cellular_component	lipid droplet
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006302	biological_process	double-strand break repair
K	0006338	biological_process	chromatin remodeling
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006734	biological_process	NADH metabolic process
K	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
K	0006914	biological_process	autophagy
K	0006974	biological_process	DNA damage response
K	0008289	molecular_function	lipid binding
K	0010494	cellular_component	cytoplasmic stress granule
K	0010498	biological_process	proteasomal protein catabolic process
K	0010918	biological_process	positive regulation of mitochondrial membrane potential
K	0016236	biological_process	macroautophagy
K	0016567	biological_process	protein ubiquitination
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0019079	biological_process	viral genome replication
K	0019903	molecular_function	protein phosphatase binding
K	0019904	molecular_function	protein domain specific binding
K	0019985	biological_process	translesion synthesis
K	0030968	biological_process	endoplasmic reticulum unfolded protein response
K	0030970	biological_process	retrograde protein transport, ER to cytosol
K	0031334	biological_process	positive regulation of protein-containing complex assembly
K	0031593	molecular_function	polyubiquitin modification-dependent protein binding
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
K	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
K	0032991	cellular_component	protein-containing complex
K	0033554	biological_process	cellular response to stress
K	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
K	0034605	biological_process	cellular response to heat
K	0034774	cellular_component	secretory granule lumen
K	0035331	biological_process	negative regulation of hippo signaling
K	0035578	cellular_component	azurophil granule lumen
K	0035617	biological_process	stress granule disassembly
K	0035800	molecular_function	deubiquitinase activator activity
K	0035861	cellular_component	site of double-strand break
K	0036297	biological_process	interstrand cross-link repair
K	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
K	0036503	biological_process	ERAD pathway
K	0036513	cellular_component	Derlin-1 retrotranslocation complex
K	0042288	molecular_function	MHC class I protein binding
K	0042802	molecular_function	identical protein binding
K	0042981	biological_process	regulation of apoptotic process
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0043531	molecular_function	ADP binding
K	0044389	molecular_function	ubiquitin-like protein ligase binding
K	0044877	molecular_function	protein-containing complex binding
K	0045184	biological_process	establishment of protein localization
K	0045202	cellular_component	synapse
K	0045732	biological_process	positive regulation of protein catabolic process
K	0045879	biological_process	negative regulation of smoothened signaling pathway
K	0046034	biological_process	ATP metabolic process
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0050807	biological_process	regulation of synapse organization
K	0051228	biological_process	mitotic spindle disassembly
K	0061775	molecular_function	cohesin loader activity
K	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
K	0070062	cellular_component	extracellular exosome
K	0070842	biological_process	aggresome assembly
K	0071218	biological_process	cellular response to misfolded protein
K	0072389	biological_process	flavin adenine dinucleotide catabolic process
K	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
K	0097352	biological_process	autophagosome maturation
K	0098978	cellular_component	glutamatergic synapse
K	0106300	biological_process	protein-DNA covalent cross-linking repair
K	0120186	biological_process	negative regulation of protein localization to chromatin
K	0140036	molecular_function	ubiquitin-modified protein reader activity
K	0140455	biological_process	cytoplasm protein quality control
K	0140584	molecular_function	chromatin extrusion motor activity
K	0140588	biological_process	chromatin looping
K	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
K	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
K	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
K	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
K	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
K	1903715	biological_process	regulation of aerobic respiration
K	1903843	biological_process	cellular response to arsenite ion
K	1903862	biological_process	positive regulation of oxidative phosphorylation
K	1904288	molecular_function	BAT3 complex binding
K	1904813	cellular_component	ficolin-1-rich granule lumen
K	1904949	cellular_component	ATPase complex
K	1905634	biological_process	regulation of protein localization to chromatin
K	1990381	molecular_function	ubiquitin-specific protease binding
K	1990730	cellular_component	VCP-NSFL1C complex
K	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
K	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
K	2001171	biological_process	positive regulation of ATP biosynthetic process
L	0000502	cellular_component	proteasome complex
L	0003689	molecular_function	DNA clamp loader activity
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006302	biological_process	double-strand break repair
L	0006338	biological_process	chromatin remodeling
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006734	biological_process	NADH metabolic process
L	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
L	0006914	biological_process	autophagy
L	0006974	biological_process	DNA damage response
L	0008289	molecular_function	lipid binding
L	0010494	cellular_component	cytoplasmic stress granule
L	0010498	biological_process	proteasomal protein catabolic process
L	0010918	biological_process	positive regulation of mitochondrial membrane potential
L	0016236	biological_process	macroautophagy
L	0016567	biological_process	protein ubiquitination
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0019079	biological_process	viral genome replication
L	0019903	molecular_function	protein phosphatase binding
L	0019904	molecular_function	protein domain specific binding
L	0019985	biological_process	translesion synthesis
L	0030968	biological_process	endoplasmic reticulum unfolded protein response
L	0030970	biological_process	retrograde protein transport, ER to cytosol
L	0031334	biological_process	positive regulation of protein-containing complex assembly
L	0031593	molecular_function	polyubiquitin modification-dependent protein binding
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032510	biological_process	endosome to lysosome transport via multivesicular body sorting pathway
L	0032991	cellular_component	protein-containing complex
L	0033554	biological_process	cellular response to stress
L	0034098	cellular_component	VCP-NPL4-UFD1 AAA ATPase complex
L	0034605	biological_process	cellular response to heat
L	0034774	cellular_component	secretory granule lumen
L	0035331	biological_process	negative regulation of hippo signaling
L	0035578	cellular_component	azurophil granule lumen
L	0035617	biological_process	stress granule disassembly
L	0035800	molecular_function	deubiquitinase activator activity
L	0035861	cellular_component	site of double-strand break
L	0036297	biological_process	interstrand cross-link repair
L	0036435	molecular_function	K48-linked polyubiquitin modification-dependent protein binding
L	0036503	biological_process	ERAD pathway
L	0036513	cellular_component	Derlin-1 retrotranslocation complex
L	0042288	molecular_function	MHC class I protein binding
L	0042802	molecular_function	identical protein binding
L	0042981	biological_process	regulation of apoptotic process
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0043531	molecular_function	ADP binding
L	0044389	molecular_function	ubiquitin-like protein ligase binding
L	0044877	molecular_function	protein-containing complex binding
L	0045184	biological_process	establishment of protein localization
L	0045202	cellular_component	synapse
L	0045732	biological_process	positive regulation of protein catabolic process
L	0045879	biological_process	negative regulation of smoothened signaling pathway
L	0046034	biological_process	ATP metabolic process
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0050807	biological_process	regulation of synapse organization
L	0051228	biological_process	mitotic spindle disassembly
L	0061775	molecular_function	cohesin loader activity
L	0061857	biological_process	endoplasmic reticulum stress-induced pre-emptive quality control
L	0070062	cellular_component	extracellular exosome
L	0070842	biological_process	aggresome assembly
L	0071218	biological_process	cellular response to misfolded protein
L	0072389	biological_process	flavin adenine dinucleotide catabolic process
L	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
L	0097352	biological_process	autophagosome maturation
L	0098978	cellular_component	glutamatergic synapse
L	0106300	biological_process	protein-DNA covalent cross-linking repair
L	0120186	biological_process	negative regulation of protein localization to chromatin
L	0140036	molecular_function	ubiquitin-modified protein reader activity
L	0140455	biological_process	cytoplasm protein quality control
L	0140584	molecular_function	chromatin extrusion motor activity
L	0140588	biological_process	chromatin looping
L	0140665	molecular_function	ATP-dependent H3-H4 histone complex chaperone activity
L	0140849	molecular_function	ATP-dependent H2AZ histone chaperone activity
L	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
L	1903006	biological_process	positive regulation of protein K63-linked deubiquitination
L	1903007	biological_process	positive regulation of Lys63-specific deubiquitinase activity
L	1903715	biological_process	regulation of aerobic respiration
L	1903843	biological_process	cellular response to arsenite ion
L	1903862	biological_process	positive regulation of oxidative phosphorylation
L	1904288	molecular_function	BAT3 complex binding
L	1904813	cellular_component	ficolin-1-rich granule lumen
L	1904949	cellular_component	ATPase complex
L	1905634	biological_process	regulation of protein localization to chromatin
L	1990381	molecular_function	ubiquitin-specific protease binding
L	1990730	cellular_component	VCP-NSFL1C complex
L	2000060	biological_process	positive regulation of ubiquitin-dependent protein catabolic process
L	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
L	2001171	biological_process	positive regulation of ATP biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
A	VAL341-ARG359
A	VAL617-ARG635
C	VAL341-ARG359
C	VAL617-ARG635
D	VAL341-ARG359
D	VAL617-ARG635

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:20512113

Chain	Residue	Details
D	PRO247
F	PRO247
F	ASN348
F	HIS384
G	PRO247
G	ASN348
G	HIS384
H	PRO247
H	ASN348
H	HIS384
I	PRO247
D	ASN348
I	ASN348
I	HIS384
J	PRO247
J	ASN348
J	HIS384
K	PRO247
K	ASN348
K	HIS384
L	PRO247
L	ASN348
D	HIS384
L	HIS384
B	PRO247
B	ASN348
B	HIS384
E	PRO247
E	ASN348
E	HIS384

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
D	GLY521
L	GLY521
B	GLY521
E	GLY521
F	GLY521
G	GLY521
H	GLY521
I	GLY521
J	GLY521
K	GLY521

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634

Chain	Residue	Details
D	LYS315
L	SER37
B	SER37
E	SER37
F	SER37
G	SER37
H	SER37
I	SER37
J	SER37
K	SER37

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
D	THR436
L	LYS315
B	LYS315
E	LYS315
F	LYS315
G	LYS315
H	LYS315
I	LYS315
J	LYS315
K	LYS315

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER462
L	THR436
D	SER702
E	THR436
F	THR436
G	THR436
H	THR436
I	THR436
J	THR436
K	THR436

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
D	LYS502
G	SER702
H	SER462
H	SER702
I	SER462
I	SER702
J	SER462
J	SER702
K	SER462
K	SER702
L	SER462
D	LYS505
L	SER702
D	LYS754
B	SER702
E	SER462
E	SER702
F	SER462
F	SER702
G	SER462

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q01853

Chain	Residue	Details
D	LYS668
F	LYS502
F	LYS505
F	LYS754
G	LYS502
G	LYS505
G	LYS754
H	LYS502
H	LYS505
H	LYS754
I	LYS502
A	LYS505
I	LYS505
I	LYS754
J	LYS502
J	LYS505
J	LYS754
K	LYS502
K	LYS505
K	LYS754
L	LYS502
L	LYS505
A	LYS754
L	LYS754
B	LYS502
B	LYS505
B	LYS754
E	LYS502
E	LYS505
E	LYS754

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
D	SER770
L	LYS668
D	SER775
E	LYS668
F	LYS668
G	LYS668
H	LYS668
I	LYS668
J	LYS668
K	LYS668

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER770
G	SER775
H	SER770
H	SER775
I	SER770
I	SER775
J	SER770
J	SER775
K	SER770
K	SER775
L	SER770
A	SER775
L	SER775
B	SER770
B	SER775
E	SER770
E	SER775
F	SER770
F	SER775
G	SER770

---