Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7WTS

Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14

Functional Information from GO Data

Chain	GOid	namespace	contents
3	0000154	biological_process	rRNA modification
3	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
3	0003723	molecular_function	RNA binding
3	0005654	cellular_component	nucleoplasm
3	0005730	cellular_component	nucleolus
3	0006364	biological_process	rRNA processing
3	0008168	molecular_function	methyltransferase activity
3	0016740	molecular_function	transferase activity
3	0031167	biological_process	rRNA methylation
3	0032040	cellular_component	small-subunit processome
3	0032259	biological_process	methylation
3	0042274	biological_process	ribosomal small subunit biogenesis
3	0052909	molecular_function	18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
3	2000234	biological_process	positive regulation of rRNA processing
5	0003723	molecular_function	RNA binding
5	0005515	molecular_function	protein binding
5	0005654	cellular_component	nucleoplasm
5	0005730	cellular_component	nucleolus
5	0006364	biological_process	rRNA processing
5	0030490	biological_process	maturation of SSU-rRNA
5	0032040	cellular_component	small-subunit processome
5	0042254	biological_process	ribosome biogenesis
B	0002181	biological_process	cytoplasmic translation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005840	cellular_component	ribosome
B	0005925	cellular_component	focal adhesion
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0022626	cellular_component	cytosolic ribosome
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	0030154	biological_process	cell differentiation
B	0032040	cellular_component	small-subunit processome
B	0042274	biological_process	ribosomal small subunit biogenesis
B	0043066	biological_process	negative regulation of apoptotic process
B	0048027	molecular_function	mRNA 5'-UTR binding
B	0070062	cellular_component	extracellular exosome
B	1990904	cellular_component	ribonucleoprotein complex
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0005925	cellular_component	focal adhesion
E	0006412	biological_process	translation
E	0008284	biological_process	positive regulation of cell population proliferation
E	0015935	cellular_component	small ribosomal subunit
E	0016020	cellular_component	membrane
E	0019843	molecular_function	rRNA binding
E	0022626	cellular_component	cytosolic ribosome
E	0022627	cellular_component	cytosolic small ribosomal subunit
E	0032040	cellular_component	small-subunit processome
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042274	biological_process	ribosomal small subunit biogenesis
E	0045727	biological_process	positive regulation of translation
E	0070062	cellular_component	extracellular exosome
E	1990904	cellular_component	ribonucleoprotein complex
G	0000028	biological_process	ribosomal small subunit assembly
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003729	molecular_function	mRNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0006364	biological_process	rRNA processing
G	0006412	biological_process	translation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0015935	cellular_component	small ribosomal subunit
G	0016020	cellular_component	membrane
G	0019901	molecular_function	protein kinase binding
G	0022626	cellular_component	cytosolic ribosome
G	0022627	cellular_component	cytosolic small ribosomal subunit
G	0030425	cellular_component	dendrite
G	0031929	biological_process	TOR signaling
G	0032040	cellular_component	small-subunit processome
G	0032868	biological_process	response to insulin
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042274	biological_process	ribosomal small subunit biogenesis
G	0042593	biological_process	glucose homeostasis
G	0043065	biological_process	positive regulation of apoptotic process
G	0044297	cellular_component	cell body
G	0071361	biological_process	cellular response to ethanol
G	0098793	cellular_component	presynapse
G	0098982	cellular_component	GABA-ergic synapse
G	1903347	biological_process	negative regulation of bicellular tight junction assembly
G	1990904	cellular_component	ribonucleoprotein complex
H	0002181	biological_process	cytoplasmic translation
H	0003723	molecular_function	RNA binding
H	0003730	molecular_function	mRNA 3'-UTR binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005925	cellular_component	focal adhesion
H	0006364	biological_process	rRNA processing
H	0006412	biological_process	translation
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0022626	cellular_component	cytosolic ribosome
H	0022627	cellular_component	cytosolic small ribosomal subunit
H	0032040	cellular_component	small-subunit processome
H	0032991	cellular_component	protein-containing complex
H	0042274	biological_process	ribosomal small subunit biogenesis
H	0045202	cellular_component	synapse
H	0048027	molecular_function	mRNA 5'-UTR binding
H	1902255	biological_process	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
H	1990904	cellular_component	ribonucleoprotein complex
H	1990948	molecular_function	ubiquitin ligase inhibitor activity
H	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
I	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I	0002181	biological_process	cytoplasmic translation
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0005925	cellular_component	focal adhesion
I	0006412	biological_process	translation
I	0016020	cellular_component	membrane
I	0022626	cellular_component	cytosolic ribosome
I	0022627	cellular_component	cytosolic small ribosomal subunit
I	0032040	cellular_component	small-subunit processome
I	0042274	biological_process	ribosomal small subunit biogenesis
I	0070062	cellular_component	extracellular exosome
I	1990904	cellular_component	ribonucleoprotein complex
J	0002181	biological_process	cytoplasmic translation
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0005925	cellular_component	focal adhesion
J	0006412	biological_process	translation
J	0015935	cellular_component	small ribosomal subunit
J	0016020	cellular_component	membrane
J	0019843	molecular_function	rRNA binding
J	0022626	cellular_component	cytosolic ribosome
J	0022627	cellular_component	cytosolic small ribosomal subunit
J	0032040	cellular_component	small-subunit processome
J	0042274	biological_process	ribosomal small subunit biogenesis
J	0045202	cellular_component	synapse
J	0070062	cellular_component	extracellular exosome
J	1990904	cellular_component	ribonucleoprotein complex
K	0003723	molecular_function	RNA binding
K	0005730	cellular_component	nucleolus
K	0005886	cellular_component	plasma membrane
K	0031965	cellular_component	nuclear membrane
L	0002181	biological_process	cytoplasmic translation
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005925	cellular_component	focal adhesion
L	0006412	biological_process	translation
L	0016020	cellular_component	membrane
L	0019843	molecular_function	rRNA binding
L	0022626	cellular_component	cytosolic ribosome
L	0022627	cellular_component	cytosolic small ribosomal subunit
L	0032040	cellular_component	small-subunit processome
L	0042274	biological_process	ribosomal small subunit biogenesis
L	0045202	cellular_component	synapse
L	0070062	cellular_component	extracellular exosome
L	1990904	cellular_component	ribonucleoprotein complex
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003729	molecular_function	mRNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0005925	cellular_component	focal adhesion
N	0006412	biological_process	translation
N	0014069	cellular_component	postsynaptic density
N	0016020	cellular_component	membrane
N	0022626	cellular_component	cytosolic ribosome
N	0022627	cellular_component	cytosolic small ribosomal subunit
N	0032040	cellular_component	small-subunit processome
N	0033119	biological_process	negative regulation of RNA splicing
N	0042274	biological_process	ribosomal small subunit biogenesis
N	0048027	molecular_function	mRNA 5'-UTR binding
N	0070062	cellular_component	extracellular exosome
N	0070181	molecular_function	small ribosomal subunit rRNA binding
N	1990904	cellular_component	ribonucleoprotein complex
O	0000028	biological_process	ribosomal small subunit assembly
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0002181	biological_process	cytoplasmic translation
O	0003723	molecular_function	RNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005515	molecular_function	protein binding
O	0005654	cellular_component	nucleoplasm
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005783	cellular_component	endoplasmic reticulum
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0005925	cellular_component	focal adhesion
O	0006412	biological_process	translation
O	0014069	cellular_component	postsynaptic density
O	0016020	cellular_component	membrane
O	0022626	cellular_component	cytosolic ribosome
O	0022627	cellular_component	cytosolic small ribosomal subunit
O	0030218	biological_process	erythrocyte differentiation
O	0030490	biological_process	maturation of SSU-rRNA
O	0032040	cellular_component	small-subunit processome
O	0042274	biological_process	ribosomal small subunit biogenesis
O	0045202	cellular_component	synapse
O	0048027	molecular_function	mRNA 5'-UTR binding
O	0070062	cellular_component	extracellular exosome
O	1990904	cellular_component	ribonucleoprotein complex
W	0002181	biological_process	cytoplasmic translation
W	0003723	molecular_function	RNA binding
W	0003735	molecular_function	structural constituent of ribosome
W	0005515	molecular_function	protein binding
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0008284	biological_process	positive regulation of cell population proliferation
W	0009615	biological_process	response to virus
W	0016020	cellular_component	membrane
W	0022626	cellular_component	cytosolic ribosome
W	0022627	cellular_component	cytosolic small ribosomal subunit
W	0032040	cellular_component	small-subunit processome
W	0042274	biological_process	ribosomal small subunit biogenesis
W	0045787	biological_process	positive regulation of cell cycle
W	0070062	cellular_component	extracellular exosome
W	1990904	cellular_component	ribonucleoprotein complex
X	0002181	biological_process	cytoplasmic translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005515	molecular_function	protein binding
X	0005654	cellular_component	nucleoplasm
X	0005730	cellular_component	nucleolus
X	0005737	cellular_component	cytoplasm
X	0005791	cellular_component	rough endoplasmic reticulum
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0015935	cellular_component	small ribosomal subunit
X	0016020	cellular_component	membrane
X	0022626	cellular_component	cytosolic ribosome
X	0022627	cellular_component	cytosolic small ribosomal subunit
X	0032040	cellular_component	small-subunit processome
X	0034063	biological_process	stress granule assembly
X	0042274	biological_process	ribosomal small subunit biogenesis
X	0045202	cellular_component	synapse
X	1990145	biological_process	maintenance of translational fidelity
X	1990904	cellular_component	ribonucleoprotein complex
Y	0002181	biological_process	cytoplasmic translation
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005730	cellular_component	nucleolus
Y	0005737	cellular_component	cytoplasm
Y	0005783	cellular_component	endoplasmic reticulum
Y	0005829	cellular_component	cytosol
Y	0005840	cellular_component	ribosome
Y	0006364	biological_process	rRNA processing
Y	0006412	biological_process	translation
Y	0015935	cellular_component	small ribosomal subunit
Y	0016020	cellular_component	membrane
Y	0022626	cellular_component	cytosolic ribosome
Y	0022627	cellular_component	cytosolic small ribosomal subunit
Y	0031369	molecular_function	translation initiation factor binding
Y	0032040	cellular_component	small-subunit processome
Y	0034101	biological_process	erythrocyte homeostasis
Y	0042274	biological_process	ribosomal small subunit biogenesis
Y	1990904	cellular_component	ribonucleoprotein complex
b	0000028	biological_process	ribosomal small subunit assembly
b	0002181	biological_process	cytoplasmic translation
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0003735	molecular_function	structural constituent of ribosome
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005840	cellular_component	ribosome
b	0006364	biological_process	rRNA processing
b	0006412	biological_process	translation
b	0008270	molecular_function	zinc ion binding
b	0014069	cellular_component	postsynaptic density
b	0022626	cellular_component	cytosolic ribosome
b	0022627	cellular_component	cytosolic small ribosomal subunit
b	0032040	cellular_component	small-subunit processome
b	0042274	biological_process	ribosomal small subunit biogenesis
b	0046872	molecular_function	metal ion binding
b	0098793	cellular_component	presynapse
b	0098978	cellular_component	glutamatergic synapse
b	0098982	cellular_component	GABA-ergic synapse
b	1990904	cellular_component	ribonucleoprotein complex
e	0003735	molecular_function	structural constituent of ribosome
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005730	cellular_component	nucleolus
q	0005737	cellular_component	cytoplasm
q	0006325	biological_process	chromatin organization
q	0006351	biological_process	DNA-templated transcription
q	0006364	biological_process	rRNA processing
q	0008168	molecular_function	methyltransferase activity
q	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
q	0016435	molecular_function	rRNA (guanine) methyltransferase activity
q	0016740	molecular_function	transferase activity
q	0032259	biological_process	methylation
q	0042254	biological_process	ribosome biogenesis
q	0046982	molecular_function	protein heterodimerization activity
q	0048471	cellular_component	perinuclear region of cytoplasm
q	0070476	biological_process	rRNA (guanine-N7)-methylation
q	2000234	biological_process	positive regulation of rRNA processing
r	0000470	biological_process	maturation of LSU-rRNA
r	0001510	biological_process	RNA methylation
r	0002098	biological_process	tRNA wobble uridine modification
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005737	cellular_component	cytoplasm
r	0005829	cellular_component	cytosol
r	0006364	biological_process	rRNA processing
r	0008276	molecular_function	protein methyltransferase activity
r	0018364	biological_process	peptidyl-glutamine methylation
r	0030488	biological_process	tRNA methylation
r	0030490	biological_process	maturation of SSU-rRNA
r	0031167	biological_process	rRNA methylation
r	0032991	cellular_component	protein-containing complex
r	0043528	cellular_component	tRNA (m2G10) methyltransferase complex
r	0045815	biological_process	transcription initiation-coupled chromatin remodeling
r	0046982	molecular_function	protein heterodimerization activity
r	0048471	cellular_component	perinuclear region of cytoplasm
r	0070476	biological_process	rRNA (guanine-N7)-methylation
r	0141106	molecular_function	tRNA methyltransferase activator activity
r	2000234	biological_process	positive regulation of rRNA processing
u	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
u	0000479	biological_process	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
u	0003723	molecular_function	RNA binding
u	0003924	molecular_function	GTPase activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005654	cellular_component	nucleoplasm
u	0005730	cellular_component	nucleolus
u	0005829	cellular_component	cytosol
u	0030686	cellular_component	90S preribosome
u	0042254	biological_process	ribosome biogenesis
x	0003676	molecular_function	nucleic acid binding
x	0003723	molecular_function	RNA binding
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005654	cellular_component	nucleoplasm
x	0005730	cellular_component	nucleolus
x	0005829	cellular_component	cytosol
x	0030490	biological_process	maturation of SSU-rRNA
x	0032040	cellular_component	small-subunit processome
x	0042274	biological_process	ribosomal small subunit biogenesis
z	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
z	0005515	molecular_function	protein binding
z	0005730	cellular_component	nucleolus
z	0030686	cellular_component	90S preribosome
z	0030688	cellular_component	preribosome, small subunit precursor

Functional Information from PROSITE/UniProt

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR

Chain	Residue	Details
W	GLY100-ARG117

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD

Chain	Residue	Details
O	LEU116-ASP138

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
X	LYS60-ARG67

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS

Chain	Residue	Details
L	GLY123-SER135

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY

Chain	Residue	Details
N	VAL98-TYR128

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVAaPkhWmLdK

Chain	Residue	Details
E	HIS8-LYS22

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGmIYDSldyakknE

Chain	Residue	Details
Y	PHE64-GLU86

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM

Chain	Residue	Details
G	ILE52-MET63

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglAkSihhARvLI

Chain	Residue	Details
J	LEU106-ILE130

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. RLvRELEKKFSgKH

Chain	Residue	Details
H	ARG78-HIS91

site_id	PS01131
Number of Residues	28
Details	RRNA_A_DIMETH Ribosomal RNA adenine dimethylases signature. VLEvGPGtGnMTvklLekakk...VvACElD

Chain	Residue	Details
3	VAL60-ASP87

site_id	PS01168
Number of Residues	33
Details	RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG

Chain	Residue	Details
b	LYS36-GLY68

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL

Chain	Residue	Details
B	LEU62-LEU74

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RrkTGGkrkpy.HkKrKyELG

Chain	Residue	Details
I	ARG11-GLY30

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34516797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MQ8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97351","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"ADP-ribosyltyrosine","evidences":[{"source":"PubMed","id":"29954836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	62
Details	Domain: {"description":"S4 RNA-binding"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62702","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"ADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"34314702","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"(3R)-3-hydroxyarginine","evidences":[{"source":"PubMed","id":"29563586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	54
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	52
Details	Domain: {"description":"KH"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62267","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"3-hydroxyproline","evidences":[{"source":"PubMed","id":"24550447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24550462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28257692","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62245","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	46
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62301","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62301","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36638793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2006","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Kanor S.","Tissot J.-D.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"UniProtKB","id":"P62281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P62281","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21044946","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q6ZWN5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62242","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01026","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of human dimethyladenosine transferase with SAM.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)