7WT8

SARS-CoV-2 Omicron variant spike in complex with Fab 9A8 (State 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0055036	cellular_component	virion membrane
A	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0016020	cellular_component	membrane
B	0019031	cellular_component	viral envelope
B	0019064	biological_process	fusion of virus membrane with host plasma membrane
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0046813	biological_process	receptor-mediated virion attachment to host cell
B	0055036	cellular_component	virion membrane
B	0075509	biological_process	endocytosis involved in viral entry into host cell
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0055036	cellular_component	virion membrane
C	0075509	biological_process	endocytosis involved in viral entry into host cell

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3597
Details	TOPO_DOM: Extracellular => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
A	GLN14-ILE1213
B	GLN14-ILE1213
C	GLN14-ILE1211

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
A	TRP1211-LEU1231
B	TRP1211-LEU1231
C	TRP1209-LEU1229

---

site_id	SWS_FT_FI3
Number of Residues	114
Details	TOPO_DOM: Cytoplasmic => ECO:0000255|HAMAP-Rule:MF_04099

Chain	Residue	Details
A	CYS1232-THR1270
B	CYS1232-THR1270
C	CYS1230-THR1268

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
A	ALA682
B	ALA682
C	ALA680

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
A	ARG812
B	ARG812
C	ARG810

---

site_id	SWS_FT_FI6
Number of Residues	15
Details	LIPID: S-palmitoyl cysteine; by host ZDHHC20 => ECO:0000269|PubMed:34599882

Chain	Residue	Details
A	CYS1232
B	CYS1240
C	CYS1230
C	CYS1231
C	CYS1235
C	CYS1236
C	CYS1238
A	CYS1233
A	CYS1237
A	CYS1238
A	CYS1240
B	CYS1232
B	CYS1233
B	CYS1237
B	CYS1238

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	LIPID: S-palmitoyl cysteine; by host ZDHHC20; partial => ECO:0000269|PubMed:34599882

Chain	Residue	Details
A	CYS1244
B	CYS1251
C	CYS1242
C	CYS1243
C	CYS1245
C	CYS1248
C	CYS1249
A	CYS1245
A	CYS1247
A	CYS1250
A	CYS1251
B	CYS1244
B	CYS1245
B	CYS1247
B	CYS1250

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN17
A	ASN1155
A	ASN1170
B	ASN17
B	ASN1155
B	ASN1170
C	ASN17
C	ASN1153
C	ASN1168

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN61
B	ASN1071
C	ASN61
C	THR124
C	ASN712
C	ASN796
C	ASN1069
A	THR124
A	ASN714
A	ASN798
A	ASN1071
B	ASN61
B	THR124
B	ASN714
B	ASN798

---

site_id	SWS_FT_FI10
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	THR76
A	GLU151
A	ASN1191
B	THR76
B	GLU151
B	ASN1191
C	THR76
C	GLU151
C	ASN1189

---

site_id	SWS_FT_FI11
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	TYR167
B	ASN328
B	ASN340
B	ASN613
B	ASN654
B	ASN1095
C	TYR167
C	ASN277
C	ASN326
C	ASN338
C	ASN611
A	ASN279
C	ASN652
C	ASN1093
A	ASN328
A	ASN340
A	ASN613
A	ASN654
A	ASN1095
B	TYR167
B	ASN279

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN233
A	ASN706
B	ASN233
B	ASN706
C	ASN233
C	ASN704

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
A	THR320
B	THR320
C	THR318

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
A	SER322
B	SER322
C	SER320

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN600
B	ASN600
C	ASN598

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
A	THR673
A	THR675
B	THR673
B	THR675
C	THR671
C	THR673

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN1131
B	ASN1131
C	ASN1129

---