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7WRA

Mouse TRPM8 in LMNG in ligand-free state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0009266biological_processresponse to temperature stimulus
A0009409biological_processresponse to cold
A0009897cellular_componentexternal side of plasma membrane
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0044853cellular_componentplasma membrane raft
A0045121cellular_componentmembrane raft
A0050955biological_processthermoception
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0009266biological_processresponse to temperature stimulus
B0009409biological_processresponse to cold
B0009897cellular_componentexternal side of plasma membrane
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0044853cellular_componentplasma membrane raft
B0045121cellular_componentmembrane raft
B0050955biological_processthermoception
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0009266biological_processresponse to temperature stimulus
C0009409biological_processresponse to cold
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0044853cellular_componentplasma membrane raft
C0045121cellular_componentmembrane raft
C0050955biological_processthermoception
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0120162biological_processpositive regulation of cold-induced thermogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0009266biological_processresponse to temperature stimulus
D0009409biological_processresponse to cold
D0009897cellular_componentexternal side of plasma membrane
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0044853cellular_componentplasma membrane raft
D0045121cellular_componentmembrane raft
D0050955biological_processthermoception
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3444
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-SER733
CGLY790-ASP796
CVAL849-LEU853
CILE985-LYS1104
DMET1-SER733
DGLY790-ASP796
DVAL849-LEU853
DILE985-LYS1104
AGLY790-ASP796
AVAL849-LEU853
AILE985-LYS1104
BMET1-SER733
BGLY790-ASP796
BVAL849-LEU853
BILE985-LYS1104
CMET1-SER733

site_idSWS_FT_FI2
Number of Residues96
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
APRO734-MET758
BPRO734-MET758
CPRO734-MET758
DPRO734-MET758

site_idSWS_FT_FI3
Number of Residues216
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AASP759-HIS765
CHIS818-LYS822
CGLN891-ARG895
CGLY913-GLU953
DASP759-HIS765
DHIS818-LYS822
DGLN891-ARG895
DGLY913-GLU953
AHIS818-LYS822
AGLN891-ARG895
AGLY913-GLU953
BASP759-HIS765
BHIS818-LYS822
BGLN891-ARG895
BGLY913-GLU953
CASP759-HIS765

site_idSWS_FT_FI4
Number of Residues92
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
ATHR766-ASN789
BTHR766-ASN789
CTHR766-ASN789
DTHR766-ASN789

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
ALEU797-LEU817
BLEU797-LEU817
CLEU797-LEU817
DLEU797-LEU817

site_idSWS_FT_FI6
Number of Residues100
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
ASER823-THR848
BSER823-THR848
CSER823-THR848
DSER823-THR848

site_idSWS_FT_FI7
Number of Residues144
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
AGLY854-ARG890
BGLY854-ARG890
CGLY854-ARG890
DGLY854-ARG890

site_idSWS_FT_FI8
Number of Residues64
DetailsINTRAMEM: Pore-forming => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
ATRP896-PHE912
BTRP896-PHE912
CTRP896-PHE912
DTRP896-PHE912

site_idSWS_FT_FI9
Number of Residues120
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
ChainResidueDetails
ATRP954-GLY984
BTRP954-GLY984
CTRP954-GLY984
DTRP954-GLY984

site_idSWS_FT_FI10
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRB
ChainResidueDetails
AGLU782
AGLN785
BGLU782
BGLN785
CGLU782
CGLN785
DGLU782
DGLN785

site_idSWS_FT_FI11
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRB, ECO:0007744|PDB:7WRC
ChainResidueDetails
AASN799
BASN799
CASN799
DASN799

site_idSWS_FT_FI12
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRC
ChainResidueDetails
AASP802
BASP802
CASP802
DASP802

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480
ChainResidueDetails
AASN934
BASN934
CASN934
DASN934

227344

PDB entries from 2024-11-13

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