7WOO

Cryo-EM structure of the inner ring protomer of the Saccharomyces cerevisiae nuclear pore complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000055	biological_process	ribosomal large subunit export from nucleus
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005643	cellular_component	nuclear pore
A	0006606	biological_process	protein import into nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0006999	biological_process	nuclear pore organization
A	0015031	biological_process	protein transport
A	0016973	biological_process	poly(A)+ mRNA export from nucleus
A	0017056	molecular_function	structural constituent of nuclear pore
A	0031965	cellular_component	nuclear membrane
A	0044612	cellular_component	nuclear pore linkers
A	0044615	cellular_component	nuclear pore nuclear basket
A	0051028	biological_process	mRNA transport
C	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
C	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005643	cellular_component	nuclear pore
C	0006405	biological_process	RNA export from nucleus
C	0006606	biological_process	protein import into nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0015031	biological_process	protein transport
C	0017056	molecular_function	structural constituent of nuclear pore
C	0031965	cellular_component	nuclear membrane
C	0036228	biological_process	protein localization to nuclear inner membrane
C	0044611	cellular_component	nuclear pore inner ring
C	0051028	biological_process	mRNA transport
C	0051292	biological_process	nuclear pore complex assembly
D	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
D	0003682	molecular_function	chromatin binding
D	0005515	molecular_function	protein binding
D	0005635	cellular_component	nuclear envelope
D	0005643	cellular_component	nuclear pore
D	0006405	biological_process	RNA export from nucleus
D	0006606	biological_process	protein import into nucleus
D	0006913	biological_process	nucleocytoplasmic transport
D	0007059	biological_process	chromosome segregation
D	0015031	biological_process	protein transport
D	0017056	molecular_function	structural constituent of nuclear pore
D	0031507	biological_process	heterochromatin formation
D	0031965	cellular_component	nuclear membrane
D	0034398	biological_process	telomere tethering at nuclear periphery
D	0036228	biological_process	protein localization to nuclear inner membrane
D	0044611	cellular_component	nuclear pore inner ring
D	0044877	molecular_function	protein-containing complex binding
D	0051028	biological_process	mRNA transport
D	0051292	biological_process	nuclear pore complex assembly
D	0099115	cellular_component	chromosome, subtelomeric region
D	1990841	molecular_function	promoter-specific chromatin binding
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0006405	biological_process	RNA export from nucleus
E	0006606	biological_process	protein import into nucleus
E	0006913	biological_process	nucleocytoplasmic transport
E	0006999	biological_process	nuclear pore organization
E	0015031	biological_process	protein transport
E	0017056	molecular_function	structural constituent of nuclear pore
E	0031965	cellular_component	nuclear membrane
E	0031990	biological_process	mRNA export from nucleus in response to heat stress
E	0044611	cellular_component	nuclear pore inner ring
E	0051028	biological_process	mRNA transport
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0006913	biological_process	nucleocytoplasmic transport
F	0006999	biological_process	nuclear pore organization
F	0015031	biological_process	protein transport
F	0017056	molecular_function	structural constituent of nuclear pore
F	0044611	cellular_component	nuclear pore inner ring
F	0046822	biological_process	regulation of nucleocytoplasmic transport
F	0051028	biological_process	mRNA transport
G	0000055	biological_process	ribosomal large subunit export from nucleus
G	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0006405	biological_process	RNA export from nucleus
G	0006409	biological_process	tRNA export from nucleus
G	0006606	biological_process	protein import into nucleus
G	0006913	biological_process	nucleocytoplasmic transport
G	0008139	molecular_function	nuclear localization sequence binding
G	0015031	biological_process	protein transport
G	0016973	biological_process	poly(A)+ mRNA export from nucleus
G	0017056	molecular_function	structural constituent of nuclear pore
G	0031965	cellular_component	nuclear membrane
G	0034398	biological_process	telomere tethering at nuclear periphery
G	0042802	molecular_function	identical protein binding
G	0044613	cellular_component	nuclear pore central transport channel
G	0044614	cellular_component	nuclear pore cytoplasmic filaments
G	0051028	biological_process	mRNA transport
G	0140693	molecular_function	molecular condensate scaffold activity
G	1990000	biological_process	amyloid fibril formation
H	0005515	molecular_function	protein binding
H	0005635	cellular_component	nuclear envelope
H	0005643	cellular_component	nuclear pore
H	0006606	biological_process	protein import into nucleus
H	0006607	biological_process	NLS-bearing protein import into nucleus
H	0006913	biological_process	nucleocytoplasmic transport
H	0006999	biological_process	nuclear pore organization
H	0015031	biological_process	protein transport
H	0017056	molecular_function	structural constituent of nuclear pore
H	0031965	cellular_component	nuclear membrane
H	0036228	biological_process	protein localization to nuclear inner membrane
H	0042802	molecular_function	identical protein binding
H	0044613	cellular_component	nuclear pore central transport channel
H	0051028	biological_process	mRNA transport
I	0000055	biological_process	ribosomal large subunit export from nucleus
I	0000056	biological_process	ribosomal small subunit export from nucleus
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005635	cellular_component	nuclear envelope
I	0005643	cellular_component	nuclear pore
I	0006405	biological_process	RNA export from nucleus
I	0006409	biological_process	tRNA export from nucleus
I	0006606	biological_process	protein import into nucleus
I	0006607	biological_process	NLS-bearing protein import into nucleus
I	0006913	biological_process	nucleocytoplasmic transport
I	0015031	biological_process	protein transport
I	0016973	biological_process	poly(A)+ mRNA export from nucleus
I	0017056	molecular_function	structural constituent of nuclear pore
I	0031965	cellular_component	nuclear membrane
I	0034399	cellular_component	nuclear periphery
I	0044613	cellular_component	nuclear pore central transport channel
I	0044615	cellular_component	nuclear pore nuclear basket
I	0051028	biological_process	mRNA transport
J	0000055	biological_process	ribosomal large subunit export from nucleus
J	0000973	biological_process	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005635	cellular_component	nuclear envelope
J	0005643	cellular_component	nuclear pore
J	0006405	biological_process	RNA export from nucleus
J	0006409	biological_process	tRNA export from nucleus
J	0006606	biological_process	protein import into nucleus
J	0006913	biological_process	nucleocytoplasmic transport
J	0008139	molecular_function	nuclear localization sequence binding
J	0015031	biological_process	protein transport
J	0016973	biological_process	poly(A)+ mRNA export from nucleus
J	0017056	molecular_function	structural constituent of nuclear pore
J	0031965	cellular_component	nuclear membrane
J	0034398	biological_process	telomere tethering at nuclear periphery
J	0042802	molecular_function	identical protein binding
J	0044613	cellular_component	nuclear pore central transport channel
J	0044614	cellular_component	nuclear pore cytoplasmic filaments
J	0051028	biological_process	mRNA transport
J	0140693	molecular_function	molecular condensate scaffold activity
J	1990000	biological_process	amyloid fibril formation
K	0005515	molecular_function	protein binding
K	0005635	cellular_component	nuclear envelope
K	0005643	cellular_component	nuclear pore
K	0006606	biological_process	protein import into nucleus
K	0006607	biological_process	NLS-bearing protein import into nucleus
K	0006913	biological_process	nucleocytoplasmic transport
K	0006999	biological_process	nuclear pore organization
K	0015031	biological_process	protein transport
K	0017056	molecular_function	structural constituent of nuclear pore
K	0031965	cellular_component	nuclear membrane
K	0036228	biological_process	protein localization to nuclear inner membrane
K	0042802	molecular_function	identical protein binding
K	0044613	cellular_component	nuclear pore central transport channel
K	0051028	biological_process	mRNA transport
L	0000055	biological_process	ribosomal large subunit export from nucleus
L	0000056	biological_process	ribosomal small subunit export from nucleus
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005635	cellular_component	nuclear envelope
L	0005643	cellular_component	nuclear pore
L	0006405	biological_process	RNA export from nucleus
L	0006409	biological_process	tRNA export from nucleus
L	0006606	biological_process	protein import into nucleus
L	0006607	biological_process	NLS-bearing protein import into nucleus
L	0006913	biological_process	nucleocytoplasmic transport
L	0015031	biological_process	protein transport
L	0016973	biological_process	poly(A)+ mRNA export from nucleus
L	0017056	molecular_function	structural constituent of nuclear pore
L	0031965	cellular_component	nuclear membrane
L	0034399	cellular_component	nuclear periphery
L	0044613	cellular_component	nuclear pore central transport channel
L	0044615	cellular_component	nuclear pore nuclear basket
L	0051028	biological_process	mRNA transport
Z	0000055	biological_process	ribosomal large subunit export from nucleus
Z	0005515	molecular_function	protein binding
Z	0005635	cellular_component	nuclear envelope
Z	0005643	cellular_component	nuclear pore
Z	0006606	biological_process	protein import into nucleus
Z	0006913	biological_process	nucleocytoplasmic transport
Z	0006999	biological_process	nuclear pore organization
Z	0015031	biological_process	protein transport
Z	0016973	biological_process	poly(A)+ mRNA export from nucleus
Z	0017056	molecular_function	structural constituent of nuclear pore
Z	0031965	cellular_component	nuclear membrane
Z	0044612	cellular_component	nuclear pore linkers
Z	0044615	cellular_component	nuclear pore nuclear basket
Z	0051028	biological_process	mRNA transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Region: {"description":"Leucine-zipper","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	81
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	130
Details	Region: {"description":"Competitive binding site of NUP57 and NUP82"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	166
Details	Region: {"description":"Required for association with NUP57 subcomplex"}

Chain

Residue

Details

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