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7WM2

Cryo-EM structure of AKT1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0009414biological_processresponse to water deprivation
A0009651biological_processresponse to salt stress
A0016020cellular_componentmembrane
A0034702cellular_componentmonoatomic ion channel complex
A0042802molecular_functionidentical protein binding
A0048767biological_processroot hair elongation
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A0090333biological_processregulation of stomatal closure
A1990573biological_processpotassium ion import across plasma membrane
B0005216molecular_functionmonoatomic ion channel activity
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0009414biological_processresponse to water deprivation
B0009651biological_processresponse to salt stress
B0016020cellular_componentmembrane
B0034702cellular_componentmonoatomic ion channel complex
B0042802molecular_functionidentical protein binding
B0048767biological_processroot hair elongation
B0055085biological_processtransmembrane transport
B0071805biological_processpotassium ion transmembrane transport
B0090333biological_processregulation of stomatal closure
B1990573biological_processpotassium ion import across plasma membrane
C0005216molecular_functionmonoatomic ion channel activity
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0009414biological_processresponse to water deprivation
C0009651biological_processresponse to salt stress
C0016020cellular_componentmembrane
C0034702cellular_componentmonoatomic ion channel complex
C0042802molecular_functionidentical protein binding
C0048767biological_processroot hair elongation
C0055085biological_processtransmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0090333biological_processregulation of stomatal closure
C1990573biological_processpotassium ion import across plasma membrane
D0005216molecular_functionmonoatomic ion channel activity
D0005242molecular_functioninward rectifier potassium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0009414biological_processresponse to water deprivation
D0009651biological_processresponse to salt stress
D0016020cellular_componentmembrane
D0034702cellular_componentmonoatomic ion channel complex
D0042802molecular_functionidentical protein binding
D0048767biological_processroot hair elongation
D0055085biological_processtransmembrane transport
D0071805biological_processpotassium ion transmembrane transport
D0090333biological_processregulation of stomatal closure
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2660
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLU61
CTYR112-SER134
CLYS180-LYS193
CASN287-SER857
DMET1-GLU61
DTYR112-SER134
DLYS180-LYS193
DASN287-SER857
ATYR112-SER134
ALYS180-LYS193
AASN287-SER857
BMET1-GLU61
BTYR112-SER134
BLYS180-LYS193
BASN287-SER857
CMET1-GLU61

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
AALA62-LEU82
BALA62-LEU82
CALA62-LEU82
DALA62-LEU82

site_idSWS_FT_FI3
Number of Residues152
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AARG83-SER90
CSER156-GLY158
CARG215-VAL241
CVAL262-LYS265
DARG83-SER90
DSER156-GLY158
DARG215-VAL241
DVAL262-LYS265
ASER156-GLY158
AARG215-VAL241
AVAL262-LYS265
BARG83-SER90
BSER156-GLY158
BARG215-VAL241
BVAL262-LYS265
CARG83-SER90

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
AILE91-GLY111
BILE91-GLY111
CILE91-GLY111
DILE91-GLY111

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
ATRP135-GLN155
BTRP135-GLN155
CTRP135-GLN155
DTRP135-GLN155

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
ALEU159-GLU179
BLEU159-GLU179
CLEU159-GLU179
DLEU159-GLU179

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
ALEU194-ALA214
BLEU194-ALA214
CLEU194-ALA214
DLEU194-ALA214

site_idSWS_FT_FI8
Number of Residues76
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
ATHR242-PRO261
BTHR242-PRO261
CTHR242-PRO261
DTHR242-PRO261

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AGLU266-GLY286
BGLU266-GLY286
CGLU266-GLY286
DGLU266-GLY286

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00060
ChainResidueDetails
ALEU372
BLEU372
CLEU372
DLEU372

227111

PDB entries from 2024-11-06

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