Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7WLU

The Flattened Structure of mPIEZO1 in Lipid Bilayer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005261	molecular_function	monoatomic cation channel activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0010831	biological_process	positive regulation of myotube differentiation
A	0016020	cellular_component	membrane
A	0031258	cellular_component	lamellipodium membrane
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
A	0033625	biological_process	positive regulation of integrin activation
A	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0050982	biological_process	detection of mechanical stimulus
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0140135	molecular_function	mechanosensitive monoatomic cation channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006812	biological_process	monoatomic cation transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0010831	biological_process	positive regulation of myotube differentiation
C	0016020	cellular_component	membrane
C	0031258	cellular_component	lamellipodium membrane
C	0032420	cellular_component	stereocilium
C	0032437	cellular_component	cuticular plate
C	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
C	0033625	biological_process	positive regulation of integrin activation
C	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0050982	biological_process	detection of mechanical stimulus
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0140135	molecular_function	mechanosensitive monoatomic cation channel activity
E	0005261	molecular_function	monoatomic cation channel activity
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006812	biological_process	monoatomic cation transport
E	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
E	0010831	biological_process	positive regulation of myotube differentiation
E	0016020	cellular_component	membrane
E	0031258	cellular_component	lamellipodium membrane
E	0032420	cellular_component	stereocilium
E	0032437	cellular_component	cuticular plate
E	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
E	0033625	biological_process	positive regulation of integrin activation
E	0033634	biological_process	positive regulation of cell-cell adhesion mediated by integrin
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0050982	biological_process	detection of mechanical stimulus
E	0098655	biological_process	monoatomic cation transmembrane transport
E	0140135	molecular_function	mechanosensitive monoatomic cation channel activity

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH

Chain	Residue	Details
A	TYR1680-HIS1686

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2091
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	VAL5-LEU25
A	LEU520-VAL540
E	ALA2019-LEU2039
E	ALA2048-VAL2068
E	ALA2077-ILE2097
E	THR2145-ILE2165
E	GLY2193-ILE2213
E	LEU2458-GLY2478
A	LEU577-VAL597
A	ILE608-TRP628
A	PHE635-PHE655
A	PHE687-PHE707
A	VAL818-PHE838
A	PRO847-TYR867
A	LEU921-TYR941
A	ILE982-ILE1002
A	MET1006-ARG1023
A	PHE27-PRO47
A	LEU1038-LEU1058
A	VAL1155-THR1175
A	ILE1179-LEU1199
A	LEU1207-LEU1227
A	CYS1232-VAL1252
A	LEU1272-LEU1292
A	ALA1678-ASN1698
A	MET1700-LEU1720
A	ILE1734-TRP1754
A	ALA1978-PHE1998
A	ALA62-HIS82
A	ALA2019-LEU2039
A	ALA2048-VAL2068
A	ALA2077-ILE2097
A	THR2145-ILE2165
A	GLY2193-ILE2213
A	LEU2458-GLY2478
C	VAL5-LEU25
C	PHE27-PRO47
C	ALA62-HIS82
C	ARG120-GLY140
A	ARG120-GLY140
C	LEU217-ILE237
C	LEU250-LEU270
C	TRP317-LEU337
C	LEU435-LEU455
C	HIS467-LEU487
C	LEU520-VAL540
C	LEU577-VAL597
C	ILE608-TRP628
C	PHE635-PHE655
C	PHE687-PHE707
A	LEU217-ILE237
C	VAL818-PHE838
C	PRO847-TYR867
C	LEU921-TYR941
C	ILE982-ILE1002
C	MET1006-ARG1023
C	LEU1038-LEU1058
C	VAL1155-THR1175
C	ILE1179-LEU1199
C	LEU1207-LEU1227
C	CYS1232-VAL1252
A	LEU250-LEU270
C	LEU1272-LEU1292
C	ALA1678-ASN1698
C	MET1700-LEU1720
C	ILE1734-TRP1754
C	ALA1978-PHE1998
C	ALA2019-LEU2039
C	ALA2048-VAL2068
C	ALA2077-ILE2097
C	THR2145-ILE2165
C	GLY2193-ILE2213
A	TRP317-LEU337
C	LEU2458-GLY2478
E	VAL5-LEU25
E	PHE27-PRO47
E	ALA62-HIS82
E	ARG120-GLY140
E	LEU217-ILE237
E	LEU250-LEU270
E	TRP317-LEU337
E	LEU435-LEU455
E	HIS467-LEU487
A	LEU435-LEU455
E	LEU520-VAL540
E	LEU577-VAL597
E	ILE608-TRP628
E	PHE635-PHE655
E	PHE687-PHE707
E	VAL818-PHE838
E	PRO847-TYR867
E	LEU921-TYR941
E	ILE982-ILE1002
E	MET1006-ARG1023
A	HIS467-LEU487
E	LEU1038-LEU1058
E	VAL1155-THR1175
E	ILE1179-LEU1199
E	LEU1207-LEU1227
E	CYS1232-VAL1252
E	LEU1272-LEU1292
E	ALA1678-ASN1698
E	MET1700-LEU1720
E	ILE1734-TRP1754
E	ALA1978-PHE1998

site_id	SWS_FT_FI2
Number of Residues	729
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:26390154

Chain	Residue	Details
A	ARG2214-SER2457
C	ARG2214-SER2457
E	ARG2214-SER2457

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q0KL00

Chain	Residue	Details
A	SER758
C	SER758
E	SER758

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19144319

Chain	Residue	Details
A	SER1385
C	SER1385
E	SER1385

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q92508

Chain	Residue	Details
A	SER1390
C	SER1390
E	SER1390

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
A	SER1627
A	SER1631
C	SER1627
C	SER1631
E	SER1627
E	SER1631

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19144319, ECO:0007744\|PubMed:21183079

Chain	Residue	Details
A	SER1646
C	SER1646
E	SER1646

site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN94
A	ASN389
C	ASN94
C	ASN389
E	ASN94
E	ASN389

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)