7WKK

Cryo-EM structure of the IR subunit from X. laevis NPC

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005634	cellular_component	nucleus
a	0005643	cellular_component	nuclear pore
a	0006913	biological_process	nucleocytoplasmic transport
a	0006999	biological_process	nuclear pore organization
a	0017056	molecular_function	structural constituent of nuclear pore
a	0044611	cellular_component	nuclear pore inner ring
A	0005634	cellular_component	nucleus
A	0005643	cellular_component	nuclear pore
A	0006913	biological_process	nucleocytoplasmic transport
A	0006999	biological_process	nuclear pore organization
A	0017056	molecular_function	structural constituent of nuclear pore
A	0044611	cellular_component	nuclear pore inner ring
b	0005643	cellular_component	nuclear pore
b	0006405	biological_process	RNA export from nucleus
b	0006606	biological_process	protein import into nucleus
b	0017056	molecular_function	structural constituent of nuclear pore
b	0044611	cellular_component	nuclear pore inner ring
B	0005643	cellular_component	nuclear pore
B	0006405	biological_process	RNA export from nucleus
B	0006606	biological_process	protein import into nucleus
B	0017056	molecular_function	structural constituent of nuclear pore
B	0044611	cellular_component	nuclear pore inner ring
c	0005643	cellular_component	nuclear pore
c	0005829	cellular_component	cytosol
c	0006606	biological_process	protein import into nucleus
c	0016973	biological_process	poly(A)+ mRNA export from nucleus
c	0017056	molecular_function	structural constituent of nuclear pore
c	0031965	cellular_component	nuclear membrane
c	0034399	cellular_component	nuclear periphery
c	0051292	biological_process	nuclear pore complex assembly
C	0005643	cellular_component	nuclear pore
C	0005829	cellular_component	cytosol
C	0006606	biological_process	protein import into nucleus
C	0016973	biological_process	poly(A)+ mRNA export from nucleus
C	0017056	molecular_function	structural constituent of nuclear pore
C	0031965	cellular_component	nuclear membrane
C	0034399	cellular_component	nuclear periphery
C	0051292	biological_process	nuclear pore complex assembly
d	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
d	0005635	cellular_component	nuclear envelope
d	0005643	cellular_component	nuclear pore
d	0006405	biological_process	RNA export from nucleus
d	0006606	biological_process	protein import into nucleus
d	0006913	biological_process	nucleocytoplasmic transport
d	0017056	molecular_function	structural constituent of nuclear pore
d	0031965	cellular_component	nuclear membrane
d	0036228	biological_process	protein localization to nuclear inner membrane
d	0044611	cellular_component	nuclear pore inner ring
D	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
D	0005635	cellular_component	nuclear envelope
D	0005643	cellular_component	nuclear pore
D	0006405	biological_process	RNA export from nucleus
D	0006606	biological_process	protein import into nucleus
D	0006913	biological_process	nucleocytoplasmic transport
D	0017056	molecular_function	structural constituent of nuclear pore
D	0031965	cellular_component	nuclear membrane
D	0036228	biological_process	protein localization to nuclear inner membrane
D	0044611	cellular_component	nuclear pore inner ring
e	0005643	cellular_component	nuclear pore
e	0005829	cellular_component	cytosol
e	0006606	biological_process	protein import into nucleus
e	0016973	biological_process	poly(A)+ mRNA export from nucleus
e	0017056	molecular_function	structural constituent of nuclear pore
e	0031965	cellular_component	nuclear membrane
e	0034399	cellular_component	nuclear periphery
e	0051292	biological_process	nuclear pore complex assembly
E	0005643	cellular_component	nuclear pore
E	0005829	cellular_component	cytosol
E	0006606	biological_process	protein import into nucleus
E	0016973	biological_process	poly(A)+ mRNA export from nucleus
E	0017056	molecular_function	structural constituent of nuclear pore
E	0031965	cellular_component	nuclear membrane
E	0034399	cellular_component	nuclear periphery
E	0051292	biological_process	nuclear pore complex assembly
f	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
f	0005635	cellular_component	nuclear envelope
f	0005643	cellular_component	nuclear pore
f	0006405	biological_process	RNA export from nucleus
f	0006606	biological_process	protein import into nucleus
f	0006913	biological_process	nucleocytoplasmic transport
f	0017056	molecular_function	structural constituent of nuclear pore
f	0031965	cellular_component	nuclear membrane
f	0036228	biological_process	protein localization to nuclear inner membrane
f	0044611	cellular_component	nuclear pore inner ring
F	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0006405	biological_process	RNA export from nucleus
F	0006606	biological_process	protein import into nucleus
F	0006913	biological_process	nucleocytoplasmic transport
F	0017056	molecular_function	structural constituent of nuclear pore
F	0031965	cellular_component	nuclear membrane
F	0036228	biological_process	protein localization to nuclear inner membrane
F	0044611	cellular_component	nuclear pore inner ring
g	0005515	molecular_function	protein binding
g	0005635	cellular_component	nuclear envelope
g	0005643	cellular_component	nuclear pore
g	0006607	biological_process	NLS-bearing protein import into nucleus
g	0006999	biological_process	nuclear pore organization
g	0017056	molecular_function	structural constituent of nuclear pore
g	0031965	cellular_component	nuclear membrane
g	0036228	biological_process	protein localization to nuclear inner membrane
g	0044613	cellular_component	nuclear pore central transport channel
G	0005515	molecular_function	protein binding
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0006607	biological_process	NLS-bearing protein import into nucleus
G	0006999	biological_process	nuclear pore organization
G	0017056	molecular_function	structural constituent of nuclear pore
G	0031965	cellular_component	nuclear membrane
G	0036228	biological_process	protein localization to nuclear inner membrane
G	0044613	cellular_component	nuclear pore central transport channel
h	0000922	cellular_component	spindle pole
h	0005543	molecular_function	phospholipid binding
h	0005643	cellular_component	nuclear pore
h	0005813	cellular_component	centrosome
h	0006405	biological_process	RNA export from nucleus
h	0006606	biological_process	protein import into nucleus
h	0017056	molecular_function	structural constituent of nuclear pore
h	0031965	cellular_component	nuclear membrane
h	0044613	cellular_component	nuclear pore central transport channel
H	0000922	cellular_component	spindle pole
H	0005543	molecular_function	phospholipid binding
H	0005643	cellular_component	nuclear pore
H	0005813	cellular_component	centrosome
H	0006405	biological_process	RNA export from nucleus
H	0006606	biological_process	protein import into nucleus
H	0017056	molecular_function	structural constituent of nuclear pore
H	0031965	cellular_component	nuclear membrane
H	0044613	cellular_component	nuclear pore central transport channel
i	0005635	cellular_component	nuclear envelope
i	0005643	cellular_component	nuclear pore
i	0006913	biological_process	nucleocytoplasmic transport
i	0008139	molecular_function	nuclear localization sequence binding
i	0017056	molecular_function	structural constituent of nuclear pore
I	0005635	cellular_component	nuclear envelope
I	0005643	cellular_component	nuclear pore
I	0006913	biological_process	nucleocytoplasmic transport
I	0008139	molecular_function	nuclear localization sequence binding
I	0017056	molecular_function	structural constituent of nuclear pore
j	0005515	molecular_function	protein binding
j	0005635	cellular_component	nuclear envelope
j	0005643	cellular_component	nuclear pore
j	0006607	biological_process	NLS-bearing protein import into nucleus
j	0006999	biological_process	nuclear pore organization
j	0017056	molecular_function	structural constituent of nuclear pore
j	0031965	cellular_component	nuclear membrane
j	0036228	biological_process	protein localization to nuclear inner membrane
j	0044613	cellular_component	nuclear pore central transport channel
J	0005515	molecular_function	protein binding
J	0005635	cellular_component	nuclear envelope
J	0005643	cellular_component	nuclear pore
J	0006607	biological_process	NLS-bearing protein import into nucleus
J	0006999	biological_process	nuclear pore organization
J	0017056	molecular_function	structural constituent of nuclear pore
J	0031965	cellular_component	nuclear membrane
J	0036228	biological_process	protein localization to nuclear inner membrane
J	0044613	cellular_component	nuclear pore central transport channel
k	0005635	cellular_component	nuclear envelope
k	0005643	cellular_component	nuclear pore
k	0006913	biological_process	nucleocytoplasmic transport
k	0008139	molecular_function	nuclear localization sequence binding
k	0017056	molecular_function	structural constituent of nuclear pore
K	0005635	cellular_component	nuclear envelope
K	0005643	cellular_component	nuclear pore
K	0006913	biological_process	nucleocytoplasmic transport
K	0008139	molecular_function	nuclear localization sequence binding
K	0017056	molecular_function	structural constituent of nuclear pore
l	0000922	cellular_component	spindle pole
l	0005543	molecular_function	phospholipid binding
l	0005643	cellular_component	nuclear pore
l	0005813	cellular_component	centrosome
l	0006405	biological_process	RNA export from nucleus
l	0006606	biological_process	protein import into nucleus
l	0017056	molecular_function	structural constituent of nuclear pore
l	0031965	cellular_component	nuclear membrane
l	0044613	cellular_component	nuclear pore central transport channel
L	0000922	cellular_component	spindle pole
L	0005543	molecular_function	phospholipid binding
L	0005643	cellular_component	nuclear pore
L	0005813	cellular_component	centrosome
L	0006405	biological_process	RNA export from nucleus
L	0006606	biological_process	protein import into nucleus
L	0017056	molecular_function	structural constituent of nuclear pore
L	0031965	cellular_component	nuclear membrane
L	0044613	cellular_component	nuclear pore central transport channel
m	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
m	0005635	cellular_component	nuclear envelope
m	0005643	cellular_component	nuclear pore
m	0006405	biological_process	RNA export from nucleus
m	0006606	biological_process	protein import into nucleus
m	0006913	biological_process	nucleocytoplasmic transport
m	0017056	molecular_function	structural constituent of nuclear pore
m	0031965	cellular_component	nuclear membrane
m	0036228	biological_process	protein localization to nuclear inner membrane
m	0044611	cellular_component	nuclear pore inner ring
M	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
M	0005635	cellular_component	nuclear envelope
M	0005643	cellular_component	nuclear pore
M	0006405	biological_process	RNA export from nucleus
M	0006606	biological_process	protein import into nucleus
M	0006913	biological_process	nucleocytoplasmic transport
M	0017056	molecular_function	structural constituent of nuclear pore
M	0031965	cellular_component	nuclear membrane
M	0036228	biological_process	protein localization to nuclear inner membrane
M	0044611	cellular_component	nuclear pore inner ring
n	0005643	cellular_component	nuclear pore
n	0006999	biological_process	nuclear pore organization
n	0030674	molecular_function	protein-macromolecule adaptor activity
n	0031965	cellular_component	nuclear membrane
n	0070762	cellular_component	nuclear pore transmembrane ring
N	0005643	cellular_component	nuclear pore
N	0006999	biological_process	nuclear pore organization
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0031965	cellular_component	nuclear membrane
N	0070762	cellular_component	nuclear pore transmembrane ring
o	0005643	cellular_component	nuclear pore
o	0006913	biological_process	nucleocytoplasmic transport
O	0005643	cellular_component	nuclear pore
O	0006913	biological_process	nucleocytoplasmic transport

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	10
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..AAgFTLGGA

Chain	Residue	Details
I	PRO71-ALA80

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LSASpvDtAMLVWDV

Chain	Residue	Details
O	LEU264-VAL278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	130
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	Topological domain: {"description":"Perinuclear space","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---