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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7WJI

Architecture of the human NALCN channelosome

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005886cellular_componentplasma membrane
A0030424cellular_componentaxon
A0034703cellular_componentcation channel complex
A0035725biological_processsodium ion transmembrane transport
A0055080biological_processmonoatomic cation homeostasis
A0098908biological_processregulation of neuronal action potential
B0005886cellular_componentplasma membrane
B0035725biological_processsodium ion transmembrane transport
B0098908biological_processregulation of neuronal action potential
C0005216molecular_functionmonoatomic ion channel activity
C0005248molecular_functionvoltage-gated sodium channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005272molecular_functionsodium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006091biological_processgeneration of precursor metabolites and energy
C0006811biological_processmonoatomic ion transport
C0006814biological_processsodium ion transport
C0008218biological_processbioluminescence
C0016020cellular_componentmembrane
C0022840molecular_functionleak channel activity
C0032224biological_processpositive regulation of synaptic transmission, cholinergic
C0032230biological_processpositive regulation of synaptic transmission, GABAergic
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0035725biological_processsodium ion transmembrane transport
C0055085biological_processtransmembrane transport
C0060075biological_processregulation of resting membrane potential
C0070588biological_processcalcium ion transmembrane transport
C0071805biological_processpotassium ion transmembrane transport
C0098908biological_processregulation of neuronal action potential
D0005886cellular_componentplasma membrane
D0015275molecular_functionstretch-activated, monoatomic cation-selective, calcium channel activity
D0035725biological_processsodium ion transmembrane transport
D0098703biological_processcalcium ion import across plasma membrane
D0098908biological_processregulation of neuronal action potential
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005246molecular_functioncalcium channel regulator activity
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035458biological_processcellular response to interferon-beta
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044305cellular_componentcalyx of Held
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060291biological_processlong-term synaptic potentiation
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0097720biological_processcalcineurin-mediated signaling
E0098901biological_processregulation of cardiac muscle cell action potential
E0099523cellular_componentpresynaptic cytosol
E0140056biological_processorganelle localization by membrane tethering
E0140238biological_processpresynaptic endocytosis
E0141110molecular_functiontransporter inhibitor activity
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
EASP21-LEU33
EASP57-PHE69
EASP94-LEU106
EASP130-PHE142
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues100
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues32
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25441029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UMO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4V0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29724949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CNO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27564677","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J03","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP29","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues253
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues135
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues76
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues20
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues24
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues29
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues16
DetailsTransmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Voltage-sensor; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33203861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CM3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"32698188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33203861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CM3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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