7WJI
Architecture of the human NALCN channelosome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0030424 | cellular_component | axon |
| A | 0034703 | cellular_component | cation channel complex |
| A | 0055080 | biological_process | monoatomic cation homeostasis |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005248 | molecular_function | voltage-gated sodium channel activity |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006091 | biological_process | generation of precursor metabolites and energy |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0008218 | biological_process | bioluminescence |
| C | 0016020 | cellular_component | membrane |
| C | 0022840 | molecular_function | leak channel activity |
| C | 0032224 | biological_process | positive regulation of synaptic transmission, cholinergic |
| C | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0034702 | cellular_component | monoatomic ion channel complex |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0060075 | biological_process | regulation of resting membrane potential |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0015275 | molecular_function | stretch-activated, monoatomic cation-selective, calcium channel activity |
| D | 0098703 | biological_process | calcium ion import across plasma membrane |
| E | 0000086 | biological_process | G2/M transition of mitotic cell cycle |
| E | 0000922 | cellular_component | spindle pole |
| E | 0002027 | biological_process | regulation of heart rate |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0005513 | biological_process | detection of calcium ion |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005813 | cellular_component | centrosome |
| E | 0005819 | cellular_component | spindle |
| E | 0005829 | cellular_component | cytosol |
| E | 0005856 | cellular_component | cytoskeleton |
| E | 0005876 | cellular_component | spindle microtubule |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| E | 0008076 | cellular_component | voltage-gated potassium channel complex |
| E | 0010800 | biological_process | positive regulation of peptidyl-threonine phosphorylation |
| E | 0010801 | biological_process | negative regulation of peptidyl-threonine phosphorylation |
| E | 0010856 | molecular_function | adenylate cyclase activator activity |
| E | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| E | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| E | 0016020 | cellular_component | membrane |
| E | 0016240 | biological_process | autophagosome membrane docking |
| E | 0019855 | molecular_function | calcium channel inhibitor activity |
| E | 0019901 | molecular_function | protein kinase binding |
| E | 0021762 | biological_process | substantia nigra development |
| E | 0030017 | cellular_component | sarcomere |
| E | 0031432 | molecular_function | titin binding |
| E | 0031514 | cellular_component | motile cilium |
| E | 0031954 | biological_process | positive regulation of protein autophosphorylation |
| E | 0031982 | cellular_component | vesicle |
| E | 0032465 | biological_process | regulation of cytokinesis |
| E | 0032516 | biological_process | positive regulation of phosphoprotein phosphatase activity |
| E | 0032991 | cellular_component | protein-containing complex |
| E | 0034704 | cellular_component | calcium channel complex |
| E | 0035307 | biological_process | positive regulation of protein dephosphorylation |
| E | 0035458 | biological_process | cellular response to interferon-beta |
| E | 0043209 | cellular_component | myelin sheath |
| E | 0043539 | molecular_function | protein serine/threonine kinase activator activity |
| E | 0044325 | molecular_function | transmembrane transporter binding |
| E | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0048306 | molecular_function | calcium-dependent protein binding |
| E | 0050848 | biological_process | regulation of calcium-mediated signaling |
| E | 0051343 | biological_process | positive regulation of cyclic-nucleotide phosphodiesterase activity |
| E | 0051592 | biological_process | response to calcium ion |
| E | 0055117 | biological_process | regulation of cardiac muscle contraction |
| E | 0060314 | biological_process | regulation of ryanodine-sensitive calcium-release channel activity |
| E | 0060315 | biological_process | negative regulation of ryanodine-sensitive calcium-release channel activity |
| E | 0060316 | biological_process | positive regulation of ryanodine-sensitive calcium-release channel activity |
| E | 0071346 | biological_process | cellular response to type II interferon |
| E | 0071902 | biological_process | positive regulation of protein serine/threonine kinase activity |
| E | 0072542 | molecular_function | protein phosphatase activator activity |
| E | 0097225 | cellular_component | sperm midpiece |
| E | 0098901 | biological_process | regulation of cardiac muscle cell action potential |
| E | 0140056 | biological_process | organelle localization by membrane tethering |
| E | 1901842 | biological_process | negative regulation of high voltage-gated calcium channel activity |
| E | 1901844 | biological_process | regulation of cell communication by electrical coupling involved in cardiac conduction |
| E | 1902494 | cellular_component | catalytic complex |
| E | 1905913 | biological_process | negative regulation of calcium ion export across plasma membrane |
| E | 1990456 | biological_process | mitochondrion-endoplasmic reticulum membrane tethering |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| E | ASP21-LEU33 | |
| E | ASP57-PHE69 | |
| E | ASP94-LEU106 | |
| E | ASP130-PHE142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| D | LEU40-ALA60 | |
| C | ASN1160-PRO1210 | |
| C | ILE1261-SER1271 | |
| C | VAL1319-SER1331 | |
| C | GLU1448-ILE1738 | |
| D | LEU417-GLN437 | |
| C | ARG159-ARG173 | |
| C | GLU323-ARG382 | |
| C | LEU440-SER447 | |
| C | GLU493-PRO502 | |
| C | ASP600-THR886 | |
| C | ASP940-THR947 | |
| C | ARG1004-LYS1015 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33203861, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| D | ASN217 | |
| E | GLU141 | |
| E | ASP96 | |
| E | ASN98 | |
| E | TYR100 | |
| E | GLU105 | |
| E | ASP130 | |
| E | ASP132 | |
| E | ASP134 | |
| E | GLN136 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 253 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PRO58-PRO65 | |
| C | PRO973-SER980 | |
| C | ALA1040-ALA1104 | |
| C | ILE1125-GLY1129 | |
| C | SER1228-PRO1236 | |
| C | LEU1294-ASN1296 | |
| C | GLY1358-ALA1378 | |
| C | MET1399-TYR1420 | |
| C | ALA130-SER137 | |
| C | PHE200-SER269 | |
| C | ILE290-PRO294 | |
| C | ASN404-ASP416 | |
| C | LEU469-SER472 | |
| C | VAL531-ALA543 | |
| C | LEU564-HIS569 | |
| C | SER907-ALA915 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PRO66-MET90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | TRP107-ILE129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PRO138-PHE158 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | SER174-MET199 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 76 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ILE270-ALA289 | |
| C | PHE544-THR563 | |
| C | MET1105-ILE1124 | |
| C | ILE1379-CYS1398 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ARG295-ILE322 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | SER383-SER403 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | GLU417-CYS439 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | SER448-ASP468 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | GLN473-LEU492 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | GLY503-PHE530 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | MET570-LEU599 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | TYR887-GLU906 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PRO916-ALA939 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ALA948-MET972 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | GLY981-MET1003 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | GLU1016-PHE1039 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PRO1130-PHE1159 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | PHE1211-LEU1227 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | VAL1237-ILE1260 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ARG1272-ALA1293 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ALA1297-HIS1318 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | MET1332-PHE1357 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:32698188, ECO:0007744|PDB:6XIW |
| Chain | Residue | Details |
| C | ALA1421-VAL1447 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33203861, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| C | ASN210 | |
| C | ASN216 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32698188, ECO:0000269|PubMed:33203861, ECO:0007744|PDB:6XIW, ECO:0007744|PDB:7CM3 |
| Chain | Residue | Details |
| C | ASN1064 |
